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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LHX2

Z-value: 0.52

Motif logo

Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
ENSG00000106689.6 LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg19_v2_chr9_+_126773880_1267738950.911.1e-02Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_65113280 0.47 ENST00000593865.1
Protein LOC100996407
chr6_-_26199499 0.45 ENST00000377831.5
histone cluster 1, H3d
chr4_+_70894130 0.31 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
histatin 3
chr14_+_67708344 0.29 ENST00000557237.1
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr19_+_42212526 0.27 ENST00000598976.1
ENST00000435837.2
ENST00000221992.6
ENST00000405816.1
Uncharacterized protein
carcinoembryonic antigen-related cell adhesion molecule 5
chr10_+_4828815 0.25 ENST00000533295.1
aldo-keto reductase family 1, member E2
chr14_-_38036271 0.25 ENST00000556024.1
RP11-356O9.2
chr14_-_51027838 0.24 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr1_+_244515930 0.23 ENST00000366537.1
ENST00000308105.4
chromosome 1 open reading frame 100
chr12_-_118796910 0.22 ENST00000541186.1
ENST00000539872.1
TAO kinase 3
chr3_-_145940214 0.22 ENST00000481701.1
phospholipid scramblase 4
chr13_+_78315466 0.21 ENST00000314070.5
ENST00000462234.1
SLAIN motif family, member 1
chr2_-_231084659 0.21 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr9_-_100854838 0.20 ENST00000538344.1
tripartite motif containing 14
chr6_-_26027480 0.19 ENST00000377364.3
histone cluster 1, H4b
chr4_-_109541539 0.19 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34 antisense RNA 1 (head to head)
chr5_-_133702761 0.18 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
cyclin-dependent kinase-like 3
chr6_+_105404899 0.18 ENST00000345080.4
lin-28 homolog B (C. elegans)
chr1_+_219347203 0.17 ENST00000366927.3
lysophospholipase-like 1
chr12_-_74686314 0.17 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
chr2_-_231084617 0.17 ENST00000409815.2
SP110 nuclear body protein
chr4_-_70653673 0.17 ENST00000512870.1
sulfotransferase family, cytosolic, 1B, member 1
chr10_-_37891859 0.16 ENST00000544824.1
MT-RNR2-like 7
chr3_+_57882061 0.16 ENST00000461354.1
ENST00000466255.1
sarcolemma associated protein
chr6_-_26199471 0.16 ENST00000341023.1
histone cluster 1, H2ad
chr2_+_200472779 0.16 ENST00000427045.1
ENST00000419243.1
AC093590.1
chr9_-_125240235 0.15 ENST00000259357.2
olfactory receptor, family 1, subfamily J, member 1
chr6_-_138833630 0.15 ENST00000533765.1
NHS-like 1
chr6_-_76072719 0.14 ENST00000370020.1
filamin A interacting protein 1
chr15_-_42565023 0.14 ENST00000566474.1
transmembrane protein 87A
chr18_+_68002675 0.14 ENST00000584919.1
Uncharacterized protein
chr2_-_166702601 0.14 ENST00000428888.1
AC009495.4
chr4_-_89951028 0.14 ENST00000506913.1
family with sequence similarity 13, member A
chr7_-_99716914 0.14 ENST00000431404.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr14_+_56584414 0.13 ENST00000559044.1
pellino E3 ubiquitin protein ligase family member 2
chr20_-_31989307 0.13 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5 regulatory subunit associated protein 1
chr1_-_89591749 0.12 ENST00000370466.3
guanylate binding protein 2, interferon-inducible
chr1_+_84630574 0.12 ENST00000413538.1
ENST00000417530.1
protein kinase, cAMP-dependent, catalytic, beta
chr19_-_30199516 0.11 ENST00000591243.1
chromosome 19 open reading frame 12
chr2_+_145780739 0.11 ENST00000597173.1
ENST00000602108.1
ENST00000420472.1
testis expressed 41 (non-protein coding)
chr20_+_31870927 0.11 ENST00000253354.1
BPI fold containing family B, member 1
chr13_+_19756173 0.10 ENST00000382988.2
RP11-408E5.4
chr1_+_160370344 0.10 ENST00000368061.2
VANGL planar cell polarity protein 2
chr20_+_30697298 0.10 ENST00000398022.2
transmembrane 9 superfamily protein member 4
chr6_+_130339710 0.10 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr17_-_39216344 0.10 ENST00000391418.2
keratin associated protein 2-3
chr9_-_98268883 0.10 ENST00000551630.1
ENST00000548420.1
patched 1
chr2_+_145780725 0.09 ENST00000451478.1
testis expressed 41 (non-protein coding)
chr2_-_89157161 0.09 ENST00000390237.2
immunoglobulin kappa constant
chr17_-_62499334 0.09 ENST00000579996.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr11_-_104827425 0.09 ENST00000393150.3
caspase 4, apoptosis-related cysteine peptidase
chr13_+_78315528 0.09 ENST00000496045.1
SLAIN motif family, member 1
chr1_-_85870177 0.09 ENST00000542148.1
dimethylarginine dimethylaminohydrolase 1
chr5_+_180682720 0.09 ENST00000599439.1
CDNA: FLJ23158 fis, clone LNG09623; Uncharacterized protein
chrX_+_18725758 0.09 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
protein phosphatase, EF-hand calcium binding domain 1
chr11_-_4719072 0.09 ENST00000396950.3
ENST00000532598.1
olfactory receptor, family 51, subfamily E, member 2
chr4_+_153021899 0.08 ENST00000509332.1
ENST00000504144.1
ENST00000499452.2
RP11-18H21.1
chr3_-_180707306 0.08 ENST00000479269.1
DnaJ (Hsp40) homolog, subfamily C, member 19
chr1_+_210501589 0.07 ENST00000413764.2
ENST00000541565.1
hedgehog acyltransferase
chr10_+_69865866 0.07 ENST00000354393.2
myopalladin
chr15_-_33180439 0.07 ENST00000559610.1
formin 1
chr16_+_88636875 0.07 ENST00000569435.1
zinc finger CCCH-type containing 18
chr3_+_62936098 0.07 ENST00000475886.1
ENST00000465684.1
ENST00000465262.1
ENST00000468072.1
long intergenic non-protein coding RNA 698
chr6_+_123038689 0.07 ENST00000354275.2
ENST00000368446.1
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr21_+_35014829 0.06 ENST00000451686.1
intersectin 1 (SH3 domain protein)
chr14_+_101297740 0.06 ENST00000555928.1
maternally expressed 3 (non-protein coding)
chr8_+_66955648 0.06 ENST00000522619.1
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr5_+_68860949 0.06 ENST00000507595.1
general transcription factor IIH, polypeptide 2C
chr4_-_185694872 0.06 ENST00000505492.1
acyl-CoA synthetase long-chain family member 1
chr15_+_51669513 0.05 ENST00000558426.1
gliomedin
chr7_-_99716940 0.05 ENST00000440225.1
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_22234381 0.05 ENST00000458533.1
Rap guanine nucleotide exchange factor (GEF) 5
chr12_+_94071129 0.05 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
CASP2 and RIPK1 domain containing adaptor with death domain
chr2_+_74648848 0.05 ENST00000409791.1
ENST00000426787.1
ENST00000348227.4
WD repeat domain 54
chr16_-_66864806 0.05 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NEDD8 activating enzyme E1 subunit 1
chr8_-_19459993 0.05 ENST00000454498.2
ENST00000520003.1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr16_+_23652773 0.05 ENST00000563998.1
ENST00000568589.1
ENST00000568272.1
dynactin 5 (p25)
chr2_-_55276320 0.05 ENST00000357376.3
reticulon 4
chr20_+_57464200 0.05 ENST00000604005.1
GNAS complex locus
chr4_-_120243545 0.05 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr5_-_67730240 0.05 ENST00000507733.1
CTC-537E7.3
chr3_-_98619999 0.04 ENST00000449482.1
discoidin, CUB and LCCL domain containing 2
chr21_-_35014027 0.04 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
crystallin, zeta (quinone reductase)-like 1
chr18_+_29027696 0.04 ENST00000257189.4
desmoglein 3
chr3_-_160823040 0.04 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr6_-_26043885 0.04 ENST00000357905.2
histone cluster 1, H2bb
chr12_+_122688090 0.04 ENST00000324189.4
ENST00000546192.1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr7_-_99716952 0.04 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chrX_+_105937068 0.04 ENST00000324342.3
ring finger protein 128, E3 ubiquitin protein ligase
chr7_-_122840015 0.04 ENST00000194130.2
solute carrier family 13 (sodium/sulfate symporter), member 1
chr2_-_99279928 0.04 ENST00000414521.2
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr13_+_24844979 0.04 ENST00000454083.1
spermatogenesis associated 13
chr5_-_78281623 0.04 ENST00000521117.1
arylsulfatase B
chr1_-_232651312 0.04 ENST00000262861.4
signal-induced proliferation-associated 1 like 2
chr17_+_45000483 0.03 ENST00000576910.2
ENST00000439730.2
ENST00000393456.2
ENST00000415811.2
ENST00000575949.1
ENST00000225567.4
ENST00000572403.1
ENST00000570879.1
golgi SNAP receptor complex member 2
chr11_+_120973375 0.03 ENST00000264037.2
tectorin alpha
chr10_+_96443204 0.03 ENST00000339022.5
cytochrome P450, family 2, subfamily C, polypeptide 18
chr19_+_20188830 0.03 ENST00000418063.2
zinc finger protein 90
chr3_-_160823158 0.03 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr2_-_10587897 0.03 ENST00000405333.1
ENST00000443218.1
ornithine decarboxylase 1
chr10_-_90712520 0.03 ENST00000224784.6
actin, alpha 2, smooth muscle, aorta
chr17_+_17082842 0.03 ENST00000579361.1
myosin phosphatase Rho interacting protein
chr14_-_23395623 0.03 ENST00000556043.1
protein arginine methyltransferase 5
chr7_-_151217166 0.03 ENST00000496004.1
Ras homolog enriched in brain
chr11_+_94706973 0.03 ENST00000536741.1
lysine (K)-specific demethylase 4D
chr7_+_37960163 0.03 ENST00000199448.4
ENST00000559325.1
ENST00000423717.1
ependymin related 1
chr2_+_234627424 0.03 ENST00000373409.3
UDP glucuronosyltransferase 1 family, polypeptide A4
chr4_+_48485341 0.03 ENST00000273861.4
solute carrier family 10, member 4
chr4_+_71384300 0.03 ENST00000504451.1
amelotin
chr21_+_35014783 0.03 ENST00000381291.4
ENST00000381285.4
ENST00000399367.3
ENST00000399352.1
ENST00000399355.2
ENST00000399349.1
intersectin 1 (SH3 domain protein)
chr5_-_75008244 0.03 ENST00000510798.1
ENST00000446329.2
POC5 centriolar protein
chr1_+_160709029 0.03 ENST00000444090.2
ENST00000441662.2
SLAM family member 7
chr11_-_104972158 0.03 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr14_-_22005343 0.03 ENST00000327430.3
spalt-like transcription factor 2
chr2_-_55237484 0.03 ENST00000394609.2
reticulon 4
chr17_-_39140549 0.03 ENST00000377755.4
keratin 40
chr3_-_131221790 0.02 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
mitochondrial ribosomal protein L3
chr14_+_56078695 0.02 ENST00000416613.1
kinectin 1 (kinesin receptor)
chr3_-_129513259 0.02 ENST00000329333.5
transmembrane and coiled-coil domain family 1
chr2_+_103035102 0.02 ENST00000264260.2
interleukin 18 receptor accessory protein
chr1_+_41448820 0.02 ENST00000372616.1
CTP synthase 1
chr9_-_28670283 0.02 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chr21_+_35014706 0.02 ENST00000399353.1
ENST00000444491.1
ENST00000381318.3
intersectin 1 (SH3 domain protein)
chr13_-_45768841 0.02 ENST00000379108.1
potassium channel tetramerization domain containing 4
chr2_+_120436733 0.02 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
transmembrane protein 177
chr8_+_55528627 0.02 ENST00000220676.1
retinitis pigmentosa 1 (autosomal dominant)
chr3_+_35722424 0.02 ENST00000396481.2
cAMP-regulated phosphoprotein, 21kDa
chr14_-_34420259 0.02 ENST00000250457.3
ENST00000547327.2
egl-9 family hypoxia-inducible factor 3
chr11_+_63606373 0.02 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MAP/microtubule affinity-regulating kinase 2
chr7_-_54826869 0.02 ENST00000450622.1
Sec61 gamma subunit
chr1_+_95616933 0.02 ENST00000604203.1
TMEM56-RWDD3 readthrough
chr15_+_58430368 0.02 ENST00000558772.1
ENST00000219919.4
aquaporin 9
chr5_+_118668846 0.02 ENST00000513374.1
tumor necrosis factor, alpha-induced protein 8
chr13_+_73632897 0.02 ENST00000377687.4
Kruppel-like factor 5 (intestinal)
chr12_-_49245916 0.02 ENST00000552512.1
ENST00000551468.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr11_+_64001962 0.02 ENST00000309422.2
vascular endothelial growth factor B
chr17_-_7760457 0.02 ENST00000576384.1
LSM domain containing 1
chrX_+_105936982 0.02 ENST00000418562.1
ring finger protein 128, E3 ubiquitin protein ligase
chr15_-_72521017 0.02 ENST00000561609.1
pyruvate kinase, muscle
chr5_-_175388327 0.01 ENST00000432305.2
ENST00000505969.1
THO complex 3
chr10_-_14372870 0.01 ENST00000357447.2
FERM domain containing 4A
chr15_-_51535208 0.01 ENST00000405913.3
ENST00000559878.1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr2_-_175712270 0.01 ENST00000295497.7
ENST00000444394.1
chimerin 1
chr2_+_210517895 0.01 ENST00000447185.1
microtubule-associated protein 2
chr13_-_46952645 0.01 ENST00000439642.1
KIAA0226-like
chr3_-_100551141 0.01 ENST00000478235.1
ENST00000471901.1
ABI family, member 3 (NESH) binding protein
chr7_-_103848405 0.01 ENST00000447452.2
ENST00000545943.1
ENST00000297431.4
origin recognition complex, subunit 5
chr8_+_22424551 0.01 ENST00000523348.1
sorbin and SH3 domain containing 3
chr11_-_46113756 0.01 ENST00000531959.1
PHD finger protein 21A
chrM_+_12331 0.01 ENST00000361567.2
mitochondrially encoded NADH dehydrogenase 5
chr3_+_33155444 0.01 ENST00000320954.6
cartilage associated protein
chr18_+_3466248 0.01 ENST00000581029.1
ENST00000581442.1
ENST00000579007.1
RP11-838N2.4
chr16_+_24741013 0.01 ENST00000315183.7
ENST00000395799.3
trinucleotide repeat containing 6A
chr1_+_28527070 0.01 ENST00000596102.1
AL353354.2
chr21_-_43735446 0.01 ENST00000398431.2
trefoil factor 3 (intestinal)
chr10_-_4285923 0.01 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr5_-_156536126 0.01 ENST00000522593.1
hepatitis A virus cellular receptor 2
chr15_+_58430567 0.01 ENST00000536493.1
aquaporin 9
chr3_+_35722487 0.01 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chr15_-_72563585 0.01 ENST00000287196.9
ENST00000260376.7
poly (ADP-ribose) polymerase family, member 6
chr2_-_55496174 0.01 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
mitochondrial translational initiation factor 2
chr1_+_145883868 0.01 ENST00000447947.2
G protein-coupled receptor 89C
chr2_+_173686303 0.01 ENST00000397087.3
Rap guanine nucleotide exchange factor (GEF) 4
chr3_-_149095652 0.01 ENST00000305366.3
transmembrane 4 L six family member 1
chr12_-_21928515 0.01 ENST00000537950.1
potassium inwardly-rectifying channel, subfamily J, member 8
chr6_+_125524785 0.01 ENST00000392482.2
tumor protein D52-like 1
chr7_-_99717463 0.01 ENST00000437822.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr14_+_52313833 0.00 ENST00000553560.1
guanine nucleotide binding protein (G protein), gamma 2
chr6_+_53883708 0.00 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
muscular LMNA-interacting protein
chr2_-_128284020 0.00 ENST00000295321.4
ENST00000455721.2
IWS1 homolog (S. cerevisiae)
chr13_+_33160553 0.00 ENST00000315596.10
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr4_-_100575781 0.00 ENST00000511828.1
Protein LOC285556
chr9_-_139137648 0.00 ENST00000358701.5
quiescin Q6 sulfhydryl oxidase 2
chr16_-_23652570 0.00 ENST00000261584.4
partner and localizer of BRCA2
chr5_+_179921344 0.00 ENST00000261951.4
CCR4-NOT transcription complex, subunit 6
chr5_-_150473127 0.00 ENST00000521001.1
TNFAIP3 interacting protein 1
chr4_-_1670632 0.00 ENST00000461064.1
family with sequence similarity 53, member A
chr3_+_119187785 0.00 ENST00000295588.4
ENST00000476573.1
protein O-glucosyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0002227 innate immune response in mucosa(GO:0002227) negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.0 0.1 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0 0.1 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)