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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF7

Z-value: 0.54

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208030647_208030689-0.671.5e-01Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_19281203 0.63 ENST00000487415.2
B9D1
B9 protein domain 1
chr17_+_19282064 0.42 ENST00000603493.1
MAPK7
mitogen-activated protein kinase 7
chr1_-_21948906 0.38 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr17_-_48277552 0.33 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chr16_+_81772633 0.30 ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
ENST00000565054.1
RP11-960L18.1
PLCG2
RP11-960L18.1
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_-_49581152 0.27 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr1_-_19229248 0.24 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr2_-_74710078 0.21 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr1_-_19229014 0.19 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr19_-_39390440 0.18 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
SIRT2
sirtuin 2
chr15_+_96873921 0.17 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr22_-_30987849 0.16 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr17_+_19281787 0.16 ENST00000482850.1
MAPK7
mitogen-activated protein kinase 7
chr19_-_39390350 0.16 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr2_+_74710194 0.16 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr19_-_7694417 0.16 ENST00000358368.4
ENST00000534844.1
XAB2
XPA binding protein 2
chr12_-_49582593 0.15 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr6_-_30585009 0.15 ENST00000376511.2
PPP1R10
protein phosphatase 1, regulatory subunit 10
chr17_+_18218587 0.14 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr22_-_30987837 0.14 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr20_-_2821756 0.14 ENST00000356872.3
ENST00000439542.1
PCED1A
PC-esterase domain containing 1A
chr20_+_2821340 0.13 ENST00000380445.3
ENST00000380469.3
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr12_-_49582837 0.13 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
TUBA1A
tubulin, alpha 1a
chr2_+_113479063 0.13 ENST00000327581.4
NT5DC4
5'-nucleotidase domain containing 4
chr1_-_19229218 0.12 ENST00000432718.1
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr6_+_30585486 0.12 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr17_+_38375574 0.12 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
WIPF2
WAS/WASL interacting protein family, member 2
chr17_-_18218237 0.12 ENST00000542570.1
TOP3A
topoisomerase (DNA) III alpha
chr1_-_6453399 0.11 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr20_-_2821271 0.11 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr15_+_92937144 0.11 ENST00000539113.1
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr16_+_20499024 0.11 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr6_-_33239612 0.10 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr14_+_38660185 0.10 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr1_-_157108266 0.10 ENST00000326786.4
ETV3
ets variant 3
chr9_+_130565147 0.09 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr6_-_33239712 0.09 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr19_+_39390587 0.09 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_-_18218270 0.08 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr20_+_2821366 0.08 ENST00000453689.1
ENST00000417508.1
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr19_-_14629224 0.08 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr7_-_47492782 0.08 ENST00000413551.1
TNS3
tensin 3
chr1_-_6453426 0.07 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr9_+_130565568 0.07 ENST00000423577.1
FPGS
folylpolyglutamate synthase
chr1_-_155243235 0.07 ENST00000355560.4
ENST00000368361.4
CLK2
CDC-like kinase 2
chr6_+_43603552 0.07 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr18_+_72166564 0.06 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr19_+_7694623 0.06 ENST00000594797.1
ENST00000456958.3
ENST00000601406.1
PET100
PET100 homolog (S. cerevisiae)
chr15_+_74422585 0.06 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr9_-_35812140 0.06 ENST00000497810.1
ENST00000396638.2
ENST00000484764.1
SPAG8
sperm associated antigen 8
chr16_-_65268795 0.06 ENST00000565901.1
ENST00000567058.1
RP11-256I9.2
RP11-256I9.2
chr9_+_130565487 0.06 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr19_-_39390212 0.06 ENST00000437828.1
SIRT2
sirtuin 2
chr17_+_38375528 0.05 ENST00000583268.1
WIPF2
WAS/WASL interacting protein family, member 2
chr3_-_33138624 0.04 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr1_-_21503337 0.04 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr5_+_173315283 0.04 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr15_+_26147507 0.03 ENST00000383019.2
ENST00000557171.1
RP11-1084I9.1
RP11-1084I9.1
chr14_+_29234870 0.03 ENST00000382535.3
FOXG1
forkhead box G1
chr19_+_39390320 0.03 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_-_40931891 0.02 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr17_+_73008755 0.02 ENST00000584208.1
ENST00000301585.5
ICT1
immature colon carcinoma transcript 1
chr15_+_92937058 0.01 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr3_-_105587879 0.01 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_+_1099675 0.01 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.1 0.4 GO:0061433 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.1 0.4 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
0.1 0.3 GO:0044691 tooth eruption(GO:0044691)
0.1 0.6 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 0.3 GO:0002316 follicular B cell differentiation(GO:0002316)
0.1 0.2 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.2 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.2 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.2 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.0 GO:0051413 response to cortisone(GO:0051413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 0.4 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1 0.2 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.1 0.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0102008 cytosolic dipeptidase activity(GO:0102008)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway