ISMARA results: KLF3

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF3

Z-value: 0.87

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Transcription factors associated with KLF3

Gene Symbol	Gene ID	Gene Info
KLF3 Ensembl NCBI GeneCards UniProt	ENSG00000109787.8	Kruppel like factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF3	hg19_v2_chr4_+_38665810_38665827	-0.23	6.6e-01	Click!

Activity profile of KLF3 motif

Sorted Z-values of KLF3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_-_46492927 Show fit	0.58	ENST00000599569.1	AP001579.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr19_+_54135310 Show fit	0.54	ENST00000376650.1	DPRX Ensembl NCBI GeneCards UniProt Show fit	divergent-paired related homeobox
chr20_+_36531544 Show fit	0.49	ENST00000448944.1	VSTM2L Ensembl NCBI GeneCards UniProt Show fit	V-set and transmembrane domain containing 2 like
chr3_+_49449636 Show fit	0.45	ENST00000273590.3	TCTA Ensembl NCBI GeneCards UniProt Show fit	T-cell leukemia translocation altered
chr8_-_123793048 Show fit	0.44	ENST00000607710.1	RP11-44N11.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-44N11.2
chr5_+_133842243 Show fit	0.42	ENST00000515627.2	AC005355.2 Ensembl NCBI GeneCards UniProt Show fit	AC005355.2
chr19_-_44008863 Show fit	0.42	ENST00000601646.1	PHLDB3 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology-like domain, family B, member 3
chr7_+_33168856 Show fit	0.40	ENST00000432983.1	BBS9 Ensembl NCBI GeneCards UniProt Show fit	Bardet-Biedl syndrome 9
chr13_-_33002151 Show fit	0.39	ENST00000495479.1 ENST00000343281.4 ENST00000464470.1 ENST00000380139.4 ENST00000380133.2	N4BP2L1 Ensembl NCBI GeneCards UniProt Show fit	NEDD4 binding protein 2-like 1
chr16_+_8715536 Show fit	0.39	ENST00000563958.1 ENST00000381920.3 ENST00000564554.1	METTL22 Ensembl NCBI GeneCards UniProt Show fit	methyltransferase like 22

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.6	GO:0048757	endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.1	0.5	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1	0.5	GO:0072675	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0	0.5	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.5	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.5	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	0.4	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.1	0.4	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
0.0	0.4	GO:0044821	meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)

Showing 1 to 10 of 122 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0005915	zonula adherens(GO:0005915)
0.0	0.6	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.5	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	0.5	GO:0035748	myelin sheath abaxonal region(GO:0035748)
0.0	0.5	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.3	GO:0035525	NF-kappaB p50/p65 complex(GO:0035525)
0.1	0.3	GO:0010370	perinucleolar chromocenter(GO:0010370)
0.0	0.3	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.3	GO:0036128	CatSper complex(GO:0036128)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.7	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.6	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.6	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0	0.5	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.5	GO:0043495	protein anchor(GO:0043495)
0.1	0.4	GO:0045127	N-acetylglucosamine kinase activity(GO:0045127)
0.0	0.4	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.1	0.3	GO:0004853	uroporphyrinogen decarboxylase activity(GO:0004853)

Showing 1 to 10 of 79 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.5	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.6	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.6	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.3	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Showing 1 to 10 of 12 entries

Results for KLF3

Z-value: 0.87

Motif logo

Transcription factors associated with KLF3

Activity-expression correlation:

Activity profile of KLF3 motif

Sorted Z-values of KLF3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: