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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for KLF15
Z-value: 0.87
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Transcription factors associated with KLF15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF15 | hg19_v2_chr3_-_126076264_126076305 | -0.45 | 3.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF15
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.0 | 1.1 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.1 | 0.6 | GO:0098728 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.0 | 0.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 0.5 | GO:1905075 | occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075) |
| 0.0 | 0.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.5 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.1 | 0.4 | GO:0060151 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 0.1 | 0.4 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.1 | 0.4 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 1.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.7 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.7 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.6 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.5 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 0.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 0.4 | GO:0031213 | RSF complex(GO:0031213) |
| 0.0 | 0.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.5 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.4 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.1 | 0.4 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
| 0.1 | 0.4 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.4 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |