ISMARA results: KLF12

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF12

Z-value: 2.20

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Transcription factors associated with KLF12

Gene Symbol	Gene ID	Gene Info
KLF12 Ensembl NCBI GeneCards UniProt	ENSG00000118922.12	Kruppel like factor 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF12	hg19_v2_chr13_-_74708372_74708409	0.78	6.7e-02	Click!

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_62475130 Show fit	2.55	ENST00000294117.5	GNG3 Ensembl NCBI GeneCards UniProt Show fit	guanine nucleotide binding protein (G protein), gamma 3
chr16_-_67978016 Show fit	2.08	ENST00000264005.5	LCAT Ensembl NCBI GeneCards UniProt Show fit	lecithin-cholesterol acyltransferase
chr9_+_131085095 Show fit	2.07	ENST00000372875.3	COQ4 Ensembl NCBI GeneCards UniProt Show fit	coenzyme Q4
chr6_-_27775694 Show fit	1.74	ENST00000377401.2	HIST1H2BL Ensembl NCBI GeneCards UniProt Show fit	histone cluster 1, H2bl
chr12_-_24737089 Show fit	1.49	ENST00000483544.1	LINC00477 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 477
chrX_+_153046456 Show fit	1.47	ENST00000393786.3 ENST00000370104.1 ENST00000370108.3 ENST00000370101.3 ENST00000430541.1 ENST00000370100.1	SRPK3 Ensembl NCBI GeneCards UniProt Show fit	SRSF protein kinase 3
chr1_-_213020991 Show fit	1.36	ENST00000332912.3	C1orf227 Ensembl NCBI GeneCards UniProt Show fit	chromosome 1 open reading frame 227
chr11_+_117070037 Show fit	1.33	ENST00000392951.4 ENST00000525531.1 ENST00000278968.6	TAGLN Ensembl NCBI GeneCards UniProt Show fit	transgelin
chr1_+_162336686 Show fit	1.24	ENST00000420220.1	C1orf226 Ensembl NCBI GeneCards UniProt Show fit	chromosome 1 open reading frame 226
chr19_-_44097188 Show fit	1.23	ENST00000594374.1	L34079.2 Ensembl NCBI GeneCards UniProt Show fit	L34079.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.1	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0	2.9	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.3	2.7	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4	2.1	GO:0090107	regulation of high-density lipoprotein particle assembly(GO:0090107)
0.2	1.9	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.1	1.9	GO:0001522	pseudouridine synthesis(GO:0001522)
0.1	1.8	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0	1.8	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	1.7	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	1.6	GO:0000245	spliceosomal complex assembly(GO:0000245)

Showing 1 to 10 of 180 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	GO:0005642	annulate lamellae(GO:0005642)
0.0	2.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	2.3	GO:0000786	nucleosome(GO:0000786)
0.0	2.1	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	2.0	GO:0014704	intercalated disc(GO:0014704)
0.0	2.0	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	1.9	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	1.9	GO:0000792	heterochromatin(GO:0000792)
0.1	1.8	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	1.7	GO:0031095	platelet dense tubular network membrane(GO:0031095)

Showing 1 to 10 of 67 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0017070	U6 snRNA binding(GO:0017070)
0.1	2.5	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	2.3	GO:0003727	single-stranded RNA binding(GO:0003727)
0.3	2.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.2	1.9	GO:0004985	opioid receptor activity(GO:0004985)
0.1	1.9	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	1.7	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	1.5	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.0	1.4	GO:0031369	translation initiation factor binding(GO:0031369)
0.1	1.2	GO:0015181	arginine transmembrane transporter activity(GO:0015181)

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.0	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
1.7	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
1.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
1.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
1.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.7	PID ARF 3PATHWAY	Arf1 pathway
0.7	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.6	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.1	2.8	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	2.8	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	2.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	2.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	2.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	1.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	1.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.0	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters

Showing 1 to 10 of 37 entries

Results for KLF12

Z-value: 2.20

Motif logo

Transcription factors associated with KLF12

Activity-expression correlation:

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: