ISMARA results: KLF1

Project

A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for KLF1

Z-value: 1.29

Motif logo

Transcription factors associated with KLF1

Gene Symbol	Gene ID	Gene Info
KLF1 Ensembl NCBI GeneCards UniProt	ENSG00000105610.4	Kruppel like factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF1	hg19_v2_chr19_-_12997995_12998021	0.48	3.4e-01	Click!

Activity profile of KLF1 motif

Sorted Z-values of KLF1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_58145889 Show fit	1.48	ENST00000547853.1	CDK4 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 4
chr2_+_74212073 Show fit	1.45	ENST00000441217.1	AC073046.25 Ensembl NCBI GeneCards UniProt Show fit	AC073046.25
chr3_+_49449636 Show fit	0.96	ENST00000273590.3	TCTA Ensembl NCBI GeneCards UniProt Show fit	T-cell leukemia translocation altered
chrX_-_16888276 Show fit	0.85	ENST00000493145.1	RBBP7 Ensembl NCBI GeneCards UniProt Show fit	retinoblastoma binding protein 7
chr17_+_7210921 Show fit	0.80	ENST00000573542.1	EIF5A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 5A
chr19_-_44008863 Show fit	0.74	ENST00000601646.1	PHLDB3 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology-like domain, family B, member 3
chr1_-_145589424 Show fit	0.72	ENST00000334513.5	NUDT17 Ensembl NCBI GeneCards UniProt Show fit	nudix (nucleoside diphosphate linked moiety X)-type motif 17
chr10_+_17272608 Show fit	0.71	ENST00000421459.2	VIM Ensembl NCBI GeneCards UniProt Show fit	vimentin
chr17_+_7210852 Show fit	0.70	ENST00000576930.1	EIF5A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 5A
chr12_-_58212487 Show fit	0.68	ENST00000549994.1	AVIL Ensembl NCBI GeneCards UniProt Show fit	advillin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.4	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.2	1.8	GO:1904637	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0	1.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	1.1	GO:0030252	growth hormone secretion(GO:0030252)
0.0	1.1	GO:0051693	actin filament capping(GO:0051693)
0.2	1.0	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1	1.0	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.0	1.0	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	1.0	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.1	0.8	GO:0070370	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)

Showing 1 to 10 of 143 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	2.2	GO:0005642	annulate lamellae(GO:0005642)
0.3	1.8	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	1.6	GO:0005871	kinesin complex(GO:0005871)
0.0	1.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	1.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.9	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.7	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.7	GO:0043034	costamere(GO:0043034)
0.2	0.6	GO:0072563	endothelial microparticle(GO:0072563)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0030332	cyclin binding(GO:0030332)
0.1	2.4	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	2.0	GO:0003777	microtubule motor activity(GO:0003777)
0.0	1.4	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2	1.0	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.0	1.0	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.9	GO:0043621	protein self-association(GO:0043621)
0.1	0.8	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.8	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	0.7	GO:1990254	keratin filament binding(GO:1990254)

Showing 1 to 10 of 76 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	1.8	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.8	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.7	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.4	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Total log-likelihood	Term	Description
2.2	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
2.0	REACTOME KINESINS	Genes involved in Kinesins
1.7	REACTOME G1 PHASE	Genes involved in G1 Phase
1.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
1.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.6	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins

Showing 1 to 10 of 19 entries

Results for KLF1

Z-value: 1.29

Motif logo

Transcription factors associated with KLF1

Activity-expression correlation:

Activity profile of KLF1 motif

Sorted Z-values of KLF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: