ISMARA results: JUN

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for JUN

Z-value: 1.04

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Transcription factors associated with JUN

Gene Symbol	Gene ID	Gene Info
JUN Ensembl NCBI GeneCards UniProt	ENSG00000177606.5	Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
JUN	hg19_v2_chr1_-_59249732_59249785	0.55	2.5e-01	Click!

Activity profile of JUN motif

Sorted Z-values of JUN motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_139944396 Show fit	0.98	ENST00000514199.1	SLC35A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 35, member A4
chr14_+_100485712 Show fit	0.93	ENST00000544450.2	EVL Ensembl NCBI GeneCards UniProt Show fit	Enah/Vasp-like
chr19_-_50979981 Show fit	0.85	ENST00000595790.1 ENST00000600100.1	FAM71E1 Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 71, member E1
chr5_+_172332220 Show fit	0.81	ENST00000518247.1 ENST00000326654.2	ERGIC1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr12_+_10365082 Show fit	0.80	ENST00000545859.1	GABARAPL1 Ensembl NCBI GeneCards UniProt Show fit	GABA(A) receptor-associated protein like 1
chr5_-_175964366 Show fit	0.80	ENST00000274811.4	RNF44 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 44
chr19_-_47616992 Show fit	0.76	ENST00000253048.5	ZC3H4 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing 4
chr19_+_50979753 Show fit	0.74	ENST00000597426.1 ENST00000334976.6 ENST00000376918.3 ENST00000598585.1	EMC10 Ensembl NCBI GeneCards UniProt Show fit	ER membrane protein complex subunit 10
chr16_+_2564254 Show fit	0.69	ENST00000565223.1	ATP6V0C Ensembl NCBI GeneCards UniProt Show fit	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr11_-_1593150 Show fit	0.68	ENST00000397374.3	DUSP8 Ensembl NCBI GeneCards UniProt Show fit	dual specificity phosphatase 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0036149	phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0	1.0	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.1	0.9	GO:0007042	lysosomal lumen acidification(GO:0007042)
0.1	0.9	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.9	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.9	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.8	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.8	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.8	GO:0035329	hippo signaling(GO:0035329)
0.2	0.7	GO:1900738	dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)

Showing 1 to 10 of 166 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0032590	dendrite membrane(GO:0032590)
0.1	1.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1	1.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.9	GO:0008180	COP9 signalosome(GO:0008180)
0.1	0.8	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)
0.1	0.8	GO:0000322	storage vacuole(GO:0000322)
0.0	0.8	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	0.7	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.0	0.7	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.6	GO:0016592	mediator complex(GO:0016592)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1	1.6	GO:0005402	sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0	1.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	1.1	GO:0030957	Tat protein binding(GO:0030957)
0.1	1.1	GO:0005522	profilin binding(GO:0005522)
0.0	1.1	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1	0.7	GO:1990932	5.8S rRNA binding(GO:1990932)
0.0	0.7	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.0	0.7	GO:0031489	myosin V binding(GO:0031489)
0.0	0.7	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)

Showing 1 to 10 of 96 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	1.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.9	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.5	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.5	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.5	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE

Showing 1 to 10 of 19 entries

Results for JUN

Z-value: 1.04

Motif logo

Transcription factors associated with JUN

Activity-expression correlation:

Activity profile of JUN motif

Sorted Z-values of JUN motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: