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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX5

Z-value: 1.02

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Transcription factors associated with IRX5

Gene Symbol Gene ID Gene Info
IRX5
ENSG00000176842.10 iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX5hg19_v2_chr16_+_54964740_54964789-0.276.0e-01Click!

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_141264597 1.59 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr8_+_84824920 1.05 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr12_+_2912363 0.70 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr1_+_196788887 0.63 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
CFHR1
CFHR2
complement factor H-related 1
complement factor H-related 2
chr12_+_21679220 0.51 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr8_-_108510224 0.48 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr7_+_23210760 0.48 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr15_+_81225699 0.48 ENST00000560027.1
KIAA1199
KIAA1199
chr4_-_104119528 0.47 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr7_-_92777606 0.47 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr11_+_31531291 0.44 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr9_+_26746951 0.43 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr3_+_180586536 0.42 ENST00000465551.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr22_-_24096562 0.42 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr14_+_56127960 0.41 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr8_-_74495065 0.40 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr9_+_42704004 0.39 ENST00000457288.1
CBWD7
COBW domain containing 7
chr8_+_101349823 0.38 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr1_-_62190793 0.36 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr20_+_10199468 0.36 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr10_-_18944123 0.36 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr14_+_39944025 0.35 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr14_+_56127989 0.35 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr1_+_63989004 0.34 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr13_+_97928395 0.34 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr12_-_76462713 0.33 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chrX_-_15353629 0.30 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr3_+_53528659 0.30 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr3_+_186158169 0.30 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr17_+_38673270 0.29 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr10_+_96698406 0.29 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr7_+_116502527 0.28 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr1_+_220267429 0.28 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr2_+_191792376 0.28 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr8_+_27631903 0.28 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr4_+_75480629 0.28 ENST00000380846.3
AREGB
amphiregulin B
chr12_-_123728548 0.27 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr3_-_27498235 0.27 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_197115818 0.26 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr1_-_89488510 0.26 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr6_+_12008986 0.26 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chrX_+_108779004 0.26 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr14_+_35747825 0.26 ENST00000540871.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr3_+_188817891 0.26 ENST00000412373.1
TPRG1
tumor protein p63 regulated 1
chr15_-_63448973 0.26 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr1_+_97188188 0.26 ENST00000541987.1
PTBP2
polypyrimidine tract binding protein 2
chr6_+_149887377 0.26 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chrX_-_19988382 0.25 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr15_-_64665911 0.25 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr19_-_36909528 0.25 ENST00000392161.3
ENST00000392171.1
ZFP82
ZFP82 zinc finger protein
chr12_+_56114151 0.25 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr9_-_19065082 0.24 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr3_+_111630451 0.24 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr17_-_67264947 0.24 ENST00000586811.1
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr18_+_22006580 0.24 ENST00000284202.4
IMPACT
impact RWD domain protein
chr2_-_228579305 0.24 ENST00000456524.1
SLC19A3
solute carrier family 19 (thiamine transporter), member 3
chr2_+_160590469 0.24 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr1_-_85156417 0.23 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr2_+_58655520 0.23 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chr7_-_16844611 0.22 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr17_+_22022437 0.22 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr8_-_17555164 0.22 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr3_-_81792780 0.22 ENST00000489715.1
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr5_+_169011033 0.21 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr18_+_22006646 0.21 ENST00000585067.1
ENST00000578221.1
IMPACT
impact RWD domain protein
chr13_+_76362974 0.21 ENST00000497947.2
LMO7
LIM domain 7
chr7_+_77469439 0.21 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr11_-_31014214 0.21 ENST00000406071.2
ENST00000339794.5
DCDC1
doublecortin domain containing 1
chr16_+_19535133 0.21 ENST00000396212.2
ENST00000381396.5
CCP110
centriolar coiled coil protein 110kDa
chr2_+_38177575 0.20 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr5_+_140566 0.20 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr1_+_53480598 0.20 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr18_+_52258390 0.20 ENST00000321600.1
DYNAP
dynactin associated protein
chr4_+_75310851 0.19 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr11_+_114310237 0.19 ENST00000539119.1
REXO2
RNA exonuclease 2
chr4_+_113558612 0.19 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr17_-_7108436 0.19 ENST00000493294.1
DLG4
discs, large homolog 4 (Drosophila)
chr3_-_149470229 0.18 ENST00000473414.1
COMMD2
COMM domain containing 2
chr17_-_29641104 0.18 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr8_+_67976593 0.18 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chrX_-_83757399 0.18 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr4_+_130017268 0.18 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr5_+_54455946 0.18 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr2_-_32236002 0.18 ENST00000404530.1
MEMO1
mediator of cell motility 1
chr11_+_57531292 0.17 ENST00000524579.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr16_+_48657361 0.17 ENST00000565072.1
RP11-42I10.1
RP11-42I10.1
chr2_+_113299990 0.17 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr3_+_101659682 0.17 ENST00000465215.1
RP11-221J22.1
RP11-221J22.1
chr15_-_56757329 0.17 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr2_+_102624977 0.17 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chr1_-_115124257 0.17 ENST00000369541.3
BCAS2
breast carcinoma amplified sequence 2
chr2_-_238333919 0.16 ENST00000409162.1
AC112721.1
Uncharacterized protein
chr11_+_114166536 0.15 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr3_-_3221358 0.15 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr1_+_212475148 0.15 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr6_+_27925019 0.15 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr17_-_18430160 0.15 ENST00000392176.3
FAM106A
family with sequence similarity 106, member A
chr4_+_26344754 0.15 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr16_+_1578674 0.15 ENST00000253934.5
TMEM204
transmembrane protein 204
chr5_-_93447333 0.15 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A
family with sequence similarity 172, member A
chr1_+_53308398 0.15 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr18_+_33709834 0.15 ENST00000358232.6
ENST00000351393.6
ENST00000442325.2
ENST00000423854.2
ENST00000350494.6
ENST00000542824.1
ELP2
elongator acetyltransferase complex subunit 2
chr19_-_52531600 0.15 ENST00000356322.6
ENST00000270649.6
ZNF614
zinc finger protein 614
chr12_-_100486668 0.14 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L
UHRF1 binding protein 1-like
chr12_-_25102252 0.14 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr10_-_35379524 0.14 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr12_+_75874460 0.14 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr4_-_104119488 0.14 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr12_+_58335360 0.14 ENST00000300145.3
XRCC6BP1
XRCC6 binding protein 1
chr15_+_49170083 0.14 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr16_+_19535235 0.14 ENST00000565376.2
ENST00000396208.2
CCP110
centriolar coiled coil protein 110kDa
chr18_-_32924372 0.14 ENST00000261332.6
ENST00000399061.3
ZNF24
zinc finger protein 24
chr15_+_21145765 0.13 ENST00000553416.1
CT60
cancer/testis antigen 60 (non-protein coding)
chr18_-_44702668 0.13 ENST00000256433.3
IER3IP1
immediate early response 3 interacting protein 1
chr20_+_54933971 0.13 ENST00000371384.3
ENST00000437418.1
FAM210B
family with sequence similarity 210, member B
chr9_+_95909309 0.13 ENST00000366188.2
RP11-370F5.4
RP11-370F5.4
chr10_+_90660832 0.13 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr10_-_14050522 0.13 ENST00000342409.2
FRMD4A
FERM domain containing 4A
chr11_-_22647350 0.13 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chr6_-_117747015 0.12 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr11_+_34999328 0.12 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex, component X
chr5_+_169010638 0.12 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
SPDL1
spindle apparatus coiled-coil protein 1
chr1_+_87458692 0.12 ENST00000370548.2
ENST00000356813.4
RP5-1052I5.2
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1
heparan sulfate 2-O-sulfotransferase 1
chr14_+_96722539 0.12 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr4_+_41361616 0.12 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr15_+_66585555 0.12 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr1_-_145826450 0.12 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr12_+_32655048 0.11 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_+_80584903 0.11 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr2_-_242041607 0.11 ENST00000434791.1
ENST00000401626.2
ENST00000439144.1
ENST00000406593.1
ENST00000495694.1
ENST00000407095.3
ENST00000391980.2
MTERFD2
MTERF domain containing 2
chr14_-_95624227 0.11 ENST00000526495.1
DICER1
dicer 1, ribonuclease type III
chr13_+_50589390 0.10 ENST00000360473.4
ENST00000312942.1
KCNRG
potassium channel regulator
chr10_-_115904361 0.10 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr17_+_58018269 0.10 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr12_+_56114189 0.10 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr7_+_6121296 0.10 ENST00000428901.1
AC004895.4
AC004895.4
chr10_-_51958906 0.10 ENST00000489640.1
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
chr8_-_101962777 0.10 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_-_186392898 0.10 ENST00000510617.1
ENST00000307588.3
CCDC110
coiled-coil domain containing 110
chr5_+_67576109 0.10 ENST00000522084.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr8_+_95558771 0.09 ENST00000391679.1
AC023632.1
HCG2009141; PRO2397; Uncharacterized protein
chr19_-_44388116 0.09 ENST00000587539.1
ZNF404
zinc finger protein 404
chr19_-_40596828 0.09 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A
zinc finger protein 780A
chr4_+_122722466 0.09 ENST00000243498.5
ENST00000379663.3
ENST00000509800.1
EXOSC9
exosome component 9
chr14_+_51706886 0.09 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr2_+_210517895 0.08 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr1_+_158969752 0.08 ENST00000566111.1
IFI16
interferon, gamma-inducible protein 16
chr7_-_99573640 0.08 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr4_-_75695366 0.08 ENST00000512743.1
BTC
betacellulin
chr8_+_27947746 0.08 ENST00000521015.1
ENST00000521570.1
ELP3
elongator acetyltransferase complex subunit 3
chr7_-_112430427 0.08 ENST00000449743.1
ENST00000441474.1
ENST00000454074.1
ENST00000447395.1
TMEM168
transmembrane protein 168
chr11_+_114310102 0.07 ENST00000265881.5
REXO2
RNA exonuclease 2
chr4_+_123653882 0.07 ENST00000433287.1
BBS12
Bardet-Biedl syndrome 12
chr15_+_66585879 0.07 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr18_-_46784778 0.07 ENST00000582399.1
DYM
dymeclin
chr1_-_114355083 0.07 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr13_+_96085847 0.07 ENST00000376873.3
CLDN10
claudin 10
chr7_-_99573677 0.07 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr5_+_96079240 0.07 ENST00000515663.1
CAST
calpastatin
chr3_-_72897545 0.07 ENST00000325599.8
SHQ1
SHQ1, H/ACA ribonucleoprotein assembly factor
chr13_-_41768654 0.07 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr7_+_13141097 0.07 ENST00000411542.1
AC011288.2
AC011288.2
chr1_-_241683001 0.07 ENST00000366560.3
FH
fumarate hydratase
chr8_+_9009202 0.07 ENST00000518496.1
RP11-10A14.4
Uncharacterized protein
chr6_-_111804905 0.07 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chrX_+_12809463 0.06 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr19_+_20959098 0.06 ENST00000360204.5
ENST00000594534.1
ZNF66
zinc finger protein 66
chr9_-_4666337 0.06 ENST00000381890.5
SPATA6L
spermatogenesis associated 6-like
chr8_-_67976509 0.06 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr15_-_81616446 0.06 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr1_+_240408560 0.06 ENST00000441342.1
ENST00000545751.1
FMN2
formin 2
chr2_-_32490801 0.06 ENST00000360906.5
ENST00000342905.6
NLRC4
NLR family, CARD domain containing 4
chr15_-_51630772 0.06 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr4_+_159131630 0.06 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
TMEM144
transmembrane protein 144
chr14_-_68159152 0.06 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr18_-_28622774 0.06 ENST00000434452.1
DSC3
desmocollin 3
chr3_-_52713729 0.06 ENST00000296302.7
ENST00000356770.4
ENST00000337303.4
ENST00000409057.1
ENST00000410007.1
ENST00000409114.3
ENST00000409767.1
ENST00000423351.1
PBRM1
polybromo 1
chr9_-_125667618 0.06 ENST00000423239.2
RC3H2
ring finger and CCCH-type domains 2
chr14_-_21737551 0.05 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr12_-_102224704 0.05 ENST00000299314.7
GNPTAB
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr6_-_138833630 0.05 ENST00000533765.1
NHSL1
NHS-like 1
chr1_-_227505289 0.05 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr2_-_40657397 0.05 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr6_-_111804393 0.05 ENST00000368802.3
ENST00000368805.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr4_-_38784592 0.05 ENST00000502321.1
TLR10
toll-like receptor 10
chr14_-_106845789 0.05 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr2_-_88125471 0.05 ENST00000398146.3
RGPD2
RANBP2-like and GRIP domain containing 2
chr10_-_31146615 0.05 ENST00000444692.2
ZNF438
zinc finger protein 438
chr4_-_22444733 0.05 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr1_-_85870177 0.05 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr12_-_58329819 0.04 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr1_-_213020991 0.04 ENST00000332912.3
C1orf227
chromosome 1 open reading frame 227
chr13_-_88323218 0.04 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr20_-_3762087 0.04 ENST00000379756.3
SPEF1
sperm flagellar 1
chr10_-_97175444 0.04 ENST00000486141.2
SORBS1
sorbin and SH3 domain containing 1
chr11_-_6790286 0.03 ENST00000338569.2
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr2_-_38056538 0.03 ENST00000413792.1
LINC00211
long intergenic non-protein coding RNA 211
chr5_+_81601166 0.03 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr3_-_46068969 0.03 ENST00000542109.1
ENST00000395946.2
XCR1
chemokine (C motif) receptor 1
chr1_-_110284384 0.03 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0071262 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.1 0.4 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 1.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.6 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.3 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 0.6 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.5 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740) Tie signaling pathway(GO:0048014)
0.0 0.2 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.2 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.3 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.3 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.1 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.0 0.2 GO:1903899 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.2 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.1 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.7 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.2 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.0 0.2 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.2 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.9 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.2 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.2 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.4 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.1 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.1 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling