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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX2

Z-value: 0.46

Motif logo

Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
ENSG00000170561.8 iroquois homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX2hg19_v2_chr5_-_2751762_27517840.721.1e-01Click!

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_148855726 0.21 ENST00000370416.4
heat shock transcription factor family, X linked 1
chrX_-_148676974 0.21 ENST00000524178.1
heat shock transcription factor family, X linked 2
chr1_-_8939265 0.18 ENST00000489867.1
enolase 1, (alpha)
chr22_+_45714672 0.18 ENST00000424557.1
family with sequence similarity 118, member A
chr4_+_22999152 0.17 ENST00000511453.1
RP11-412P11.1
chr6_+_13272904 0.16 ENST00000379335.3
ENST00000379329.1
phosphatase and actin regulator 1
chr4_-_83821676 0.16 ENST00000355196.2
ENST00000507676.1
ENST00000506495.1
ENST00000507051.1
SEC31 homolog A (S. cerevisiae)
chr17_+_76037081 0.16 ENST00000588549.1
trinucleotide repeat containing 6C
chr9_+_130159593 0.14 ENST00000419132.1
solute carrier family 2 (facilitated glucose transporter), member 8
chr1_-_151148442 0.13 ENST00000441701.1
ENST00000416280.2
tropomodulin 4 (muscle)
chrX_-_70331298 0.12 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
interleukin 2 receptor, gamma
chr2_+_159651821 0.12 ENST00000309950.3
ENST00000409042.1
death associated protein-like 1
chr1_-_151148492 0.12 ENST00000295314.4
tropomodulin 4 (muscle)
chr2_-_46844242 0.12 ENST00000281382.6
phosphatidylinositol glycan anchor biosynthesis, class F
chr7_-_105332084 0.12 ENST00000472195.1
ataxin 7-like 1
chr11_+_33037652 0.12 ENST00000311388.3
DEP domain containing 7
chr14_+_52327350 0.11 ENST00000555472.1
ENST00000556766.1
guanine nucleotide binding protein (G protein), gamma 2
chr13_+_35516390 0.11 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
neurobeachin
chr4_+_88896819 0.11 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
secreted phosphoprotein 1
chr19_+_13134772 0.11 ENST00000587760.1
ENST00000585575.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_238649319 0.10 ENST00000400946.2
long intergenic non-protein coding RNA 1139
chr3_-_186262166 0.10 ENST00000307944.5
crystallin, gamma S
chrX_+_155227246 0.10 ENST00000244174.5
ENST00000424344.3
interleukin 9 receptor
chr20_+_2083540 0.10 ENST00000400064.3
serine/threonine kinase 35
chr13_-_24007815 0.10 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_-_185641681 0.10 ENST00000259043.7
transformer 2 beta homolog (Drosophila)
chrX_-_100129128 0.10 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NADPH oxidase 1
chr8_-_90993869 0.09 ENST00000517772.1
nibrin
chr1_-_149783914 0.09 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
histone cluster 2, H2bf
chr11_+_77532233 0.09 ENST00000525409.1
adipogenesis associated, Mth938 domain containing
chr1_+_244227632 0.09 ENST00000598000.1
Uncharacterized protein; cDNA FLJ42623 fis, clone BRACE3015894
chr9_-_35812236 0.09 ENST00000340291.2
sperm associated antigen 8
chr16_+_58537737 0.09 ENST00000561738.1
NDRG family member 4
chr2_-_3504587 0.08 ENST00000415131.1
acireductone dioxygenase 1
chr11_+_35222629 0.08 ENST00000526553.1
CD44 molecule (Indian blood group)
chr16_+_21244986 0.08 ENST00000311620.5
ankyrin repeat and sterile alpha motif domain containing 4B
chr8_+_26240414 0.08 ENST00000380629.2
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr20_-_35329063 0.08 ENST00000422536.1
NDRG family member 3
chr11_-_118305921 0.08 ENST00000532619.1
RP11-770J1.4
chr2_-_42180940 0.07 ENST00000378711.2
chromosome 2 open reading frame 91
chr10_-_4285923 0.07 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr3_-_11645925 0.07 ENST00000413604.1
vestigial like 4 (Drosophila)
chr17_-_41322332 0.07 ENST00000590740.1
RP11-242D8.1
chr12_+_4714145 0.07 ENST00000545342.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr3_+_193853927 0.07 ENST00000232424.3
hes family bHLH transcription factor 1
chrX_+_155227371 0.07 ENST00000369423.2
ENST00000540897.1
interleukin 9 receptor
chr11_+_62648357 0.07 ENST00000541372.1
ENST00000539458.1
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr10_+_70320413 0.06 ENST00000373644.4
tet methylcytosine dioxygenase 1
chr5_-_71803177 0.06 ENST00000414109.2
zinc finger protein 366
chr5_-_150138246 0.06 ENST00000518015.1
dynactin 4 (p62)
chr8_-_124665190 0.06 ENST00000325995.7
kelch-like family member 38
chr8_+_67104323 0.06 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
long intergenic non-protein coding RNA 967
chr12_+_53773944 0.05 ENST00000551969.1
ENST00000327443.4
Sp1 transcription factor
chr21_-_22175341 0.05 ENST00000416768.1
ENST00000452561.1
ENST00000419299.1
ENST00000437238.1
long intergenic non-protein coding RNA 320
chr7_-_33140498 0.05 ENST00000448915.1
retinitis pigmentosa 9 (autosomal dominant)
chr11_-_33795893 0.05 ENST00000526785.1
ENST00000534136.1
ENST00000265651.3
ENST00000530401.1
ENST00000448981.2
F-box protein 3
chr7_+_93652116 0.05 ENST00000415536.1
AC003092.1
chrX_-_100129320 0.05 ENST00000372966.3
NADPH oxidase 1
chr2_+_46844290 0.05 ENST00000238892.3
cysteine-rich PDZ-binding protein
chr13_-_46679144 0.05 ENST00000181383.4
carboxypeptidase B2 (plasma)
chr3_-_114343768 0.05 ENST00000393785.2
zinc finger and BTB domain containing 20
chr20_-_60294804 0.05 ENST00000317652.1
Uncharacterized protein
chr11_+_62648336 0.05 ENST00000338663.7
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr7_+_150065278 0.05 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
replication initiator 1
chr10_+_46997926 0.05 ENST00000374314.4
G protein regulated inducer of neurite outgrowth 2
chr2_-_98280383 0.05 ENST00000289228.5
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr17_+_34842512 0.05 ENST00000588253.1
ENST00000592616.1
ENST00000590858.1
ENST00000588357.1
zinc finger, HIT-type containing 3
chr1_-_111506562 0.05 ENST00000485275.2
ENST00000369763.4
ligand dependent nuclear receptor interacting factor 1
chr5_-_138210977 0.05 ENST00000274711.6
ENST00000521094.2
leucine rich repeat transmembrane neuronal 2
chr7_-_130598059 0.05 ENST00000432045.2
microRNA 29a
chr3_+_184534994 0.05 ENST00000441141.1
ENST00000445089.1
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr17_-_7761172 0.05 ENST00000333775.5
ENST00000575771.1
LSM domain containing 1
chr17_+_7761013 0.05 ENST00000571846.1
cytochrome b5 domain containing 1
chr1_-_173793458 0.04 ENST00000356198.2
centromere protein L
chr2_-_70520539 0.04 ENST00000482975.2
ENST00000438261.1
small nuclear ribonucleoprotein polypeptide G
chr4_-_80247162 0.04 ENST00000286794.4
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr16_+_57680043 0.04 ENST00000569154.1
G protein-coupled receptor 56
chr14_+_52327109 0.04 ENST00000335281.4
guanine nucleotide binding protein (G protein), gamma 2
chr8_+_67405794 0.04 ENST00000522977.1
ENST00000480005.1
chromosome 8 open reading frame 46
chr8_+_98900132 0.04 ENST00000520016.1
matrilin 2
chr1_+_113010056 0.04 ENST00000369686.5
wingless-type MMTV integration site family, member 2B
chr2_-_166060552 0.04 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chr7_-_130597935 0.04 ENST00000447307.1
ENST00000418546.1
microRNA 29a
chr9_-_79267432 0.04 ENST00000424866.1
prune homolog 2 (Drosophila)
chr1_+_67673297 0.04 ENST00000425614.1
ENST00000395227.1
interleukin 23 receptor
chr9_+_79792410 0.04 ENST00000357409.5
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chrX_-_21676442 0.04 ENST00000379499.2
kelch-like family member 34
chr10_+_102672712 0.04 ENST00000370271.3
ENST00000370269.3
ENST00000609386.1
family with sequence similarity 178, member A
chr6_-_53013620 0.04 ENST00000259803.7
glial cells missing homolog 1 (Drosophila)
chr5_-_150138061 0.04 ENST00000521533.1
ENST00000424236.1
dynactin 4 (p62)
chr14_+_62462541 0.04 ENST00000430451.2
synaptotagmin XVI
chr3_-_126327398 0.04 ENST00000383572.2
thioredoxin reductase 3 neighbor
chr16_-_12062333 0.03 ENST00000597717.1
Uncharacterized protein
chr19_+_3762645 0.03 ENST00000330133.4
mitochondrial ribosomal protein L54
chr2_+_196313239 0.03 ENST00000413290.1
AC064834.1
chr2_+_27851863 0.03 ENST00000264718.3
ENST00000610189.1
GPN-loop GTPase 1
chr17_-_8055747 0.03 ENST00000317276.4
ENST00000581703.1
period circadian clock 1
chr11_-_76381029 0.03 ENST00000407242.2
ENST00000421973.1
leucine rich repeat containing 32
chr20_+_56136136 0.03 ENST00000319441.4
ENST00000543666.1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr17_-_60885645 0.03 ENST00000544856.2
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr2_+_171640291 0.03 ENST00000409885.1
glutamate-rich 2
chr18_-_53070913 0.03 ENST00000568186.1
ENST00000564228.1
transcription factor 4
chr9_+_12695702 0.03 ENST00000381136.2
tyrosinase-related protein 1
chr1_+_113009163 0.03 ENST00000256640.5
wingless-type MMTV integration site family, member 2B
chr15_-_44486632 0.03 ENST00000484674.1
FERM domain containing 5
chr3_+_148457585 0.03 ENST00000402260.1
angiotensin II receptor, type 1
chr4_-_153332886 0.03 ENST00000603841.1
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr13_+_28519343 0.03 ENST00000381026.3
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2
chr16_+_56899114 0.03 ENST00000566786.1
ENST00000438926.2
ENST00000563236.1
ENST00000262502.5
solute carrier family 12 (sodium/chloride transporter), member 3
chr1_+_17516275 0.03 ENST00000412427.1
RP11-380J14.1
chr3_-_194072019 0.03 ENST00000429275.1
ENST00000323830.3
carboxypeptidase N, polypeptide 2
chr9_-_47314222 0.02 ENST00000420228.1
ENST00000438517.1
ENST00000414020.1
AL953854.2
chr17_+_34842473 0.02 ENST00000490126.2
ENST00000225410.4
zinc finger, HIT-type containing 3
chr19_-_40336969 0.02 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
fibrillarin
chr12_-_66275350 0.02 ENST00000536648.1
Uncharacterized protein
chr17_+_900342 0.02 ENST00000327158.4
translocase of inner mitochondrial membrane 22 homolog (yeast)
chr16_+_33205585 0.02 ENST00000360260.2
ENST00000398666.3
TP53 target 3C
chr16_+_33262120 0.02 ENST00000569741.1
ENST00000380147.3
TP53 target 3B
chr15_+_44580955 0.02 ENST00000345795.2
ENST00000360824.3
cancer susceptibility candidate 4
chr12_-_112856623 0.02 ENST00000551291.2
ribosomal protein L6
chr8_+_24151553 0.02 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM metallopeptidase domain 28
chr17_-_7761256 0.02 ENST00000575208.1
LSM domain containing 1
chr5_-_138211051 0.02 ENST00000518785.1
leucine rich repeat transmembrane neuronal 2
chr4_+_109571740 0.02 ENST00000361564.4
oligosaccharyltransferase complex subunit (non-catalytic)
chr8_-_11996586 0.02 ENST00000333796.3
ubiquitin specific peptidase 17-like family member 2
chr10_+_96522361 0.02 ENST00000371321.3
cytochrome P450, family 2, subfamily C, polypeptide 19
chr1_-_190446759 0.02 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr14_-_64971893 0.02 ENST00000555220.1
zinc finger and BTB domain containing 25
chr12_+_9144626 0.02 ENST00000543895.1
killer cell lectin-like receptor subfamily G, member 1
chr14_+_58797974 0.02 ENST00000417477.2
AT rich interactive domain 4A (RBP1-like)
chr7_+_95115210 0.02 ENST00000428113.1
ENST00000325885.5
ankyrin repeat and SOCS box containing 4
chr10_+_90660832 0.02 ENST00000371924.1
STAM binding protein-like 1
chr16_-_32687431 0.02 ENST00000398680.3
ENST00000569420.1
TP53 target 3
chr8_-_29939933 0.02 ENST00000522794.1
transmembrane protein 66
chr6_-_27841289 0.02 ENST00000355981.2
histone cluster 1, H4l
chr2_+_171034646 0.02 ENST00000409044.3
ENST00000408978.4
myosin IIIB
chr12_-_16758304 0.02 ENST00000320122.6
LIM domain only 3 (rhombotin-like 2)
chr14_+_23790655 0.01 ENST00000397276.2
poly(A) binding protein, nuclear 1
chr4_+_158142750 0.01 ENST00000505888.1
ENST00000449365.1
glutamate receptor, ionotropic, AMPA 2
chr2_-_46844159 0.01 ENST00000474980.1
ENST00000306465.4
phosphatidylinositol glycan anchor biosynthesis, class F
chr12_+_90313394 0.01 ENST00000549551.1
RP11-654D12.2
chr12_+_48178706 0.01 ENST00000599515.1
Uncharacterized protein
chr10_-_100027943 0.01 ENST00000260702.3
lysyl oxidase-like 4
chr4_+_158141899 0.01 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr9_-_73736511 0.01 ENST00000377110.3
ENST00000377111.2
transient receptor potential cation channel, subfamily M, member 3
chr3_-_150612089 0.01 ENST00000397891.3
family with sequence similarity 188, member B2
chr4_+_119606523 0.01 ENST00000388822.5
ENST00000506780.1
ENST00000508801.1
methyltransferase like 14
chr12_-_91505608 0.01 ENST00000266718.4
lumican
chr4_-_168155417 0.01 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr13_-_22033392 0.01 ENST00000320220.9
ENST00000415724.1
ENST00000422251.1
ENST00000382466.3
ENST00000542645.1
ENST00000400590.3
zinc finger, DHHC-type containing 20
chr2_-_166060571 0.01 ENST00000360093.3
sodium channel, voltage-gated, type III, alpha subunit
chr3_-_58419537 0.01 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
pyruvate dehydrogenase (lipoamide) beta
chr7_-_14880892 0.01 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
diacylglycerol kinase, beta 90kDa
chr17_-_60885700 0.01 ENST00000583600.1
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr21_+_43823983 0.01 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
ubiquitin associated and SH3 domain containing A
chr18_+_50278430 0.01 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
deleted in colorectal carcinoma
chr9_-_23779367 0.01 ENST00000440102.1
ELAV like neuron-specific RNA binding protein 2
chr5_-_94417186 0.01 ENST00000312216.8
ENST00000512425.1
multiple C2 domains, transmembrane 1
chr4_+_159131596 0.01 ENST00000512481.1
transmembrane protein 144
chr2_+_168675182 0.01 ENST00000305861.1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr17_-_27054952 0.01 ENST00000580518.1
TLC domain containing 1
chr4_+_158141843 0.01 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr17_-_60885659 0.01 ENST00000311269.5
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr14_+_75536280 0.00 ENST00000238686.8
zinc finger, C2HC-type containing 1C
chr11_-_110561721 0.00 ENST00000357139.3
Rho GTPase activating protein 20
chr2_+_133874577 0.00 ENST00000596384.1
HCG2006742; Protein LOC100996685
chr3_+_46616017 0.00 ENST00000542931.1
teratocarcinoma-derived growth factor 1
chr16_-_4401258 0.00 ENST00000577031.1
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr17_-_2614927 0.00 ENST00000435359.1
clustered mitochondria (cluA/CLU1) homolog
chr14_+_75536335 0.00 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
zinc finger, C2HC-type containing 1C
chr1_+_204839959 0.00 ENST00000404076.1
neurofascin
chr12_+_54402790 0.00 ENST00000040584.4
homeobox C8
chr12_+_128399965 0.00 ENST00000540882.1
ENST00000542089.1
long intergenic non-protein coding RNA 507
chr8_+_81397876 0.00 ENST00000430430.1
zinc finger and BTB domain containing 10
chr9_+_34957477 0.00 ENST00000544237.1
KIAA1045
chr16_-_71323617 0.00 ENST00000563876.1
cap methyltransferase 2
chr3_+_31574189 0.00 ENST00000295770.2
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
chr2_-_233877912 0.00 ENST00000264051.3
neuronal guanine nucleotide exchange factor
chr8_-_82359662 0.00 ENST00000519260.1
ENST00000256103.2
peripheral myelin protein 2
chr2_-_166060382 0.00 ENST00000409101.3
sodium channel, voltage-gated, type III, alpha subunit
chr12_+_128399917 0.00 ENST00000544645.1
long intergenic non-protein coding RNA 507

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.2 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.0 0.2 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.1 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.1 GO:0060356 leucine import(GO:0060356)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.0 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.0 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.0 GO:1904640 response to methionine(GO:1904640)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.0 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0004913 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.0 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.0 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.0 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)