Project
A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for IRF9
Z-value: 7.23
Motif logo
Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 1.00 | 6.3e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 167.8 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 1.0 | 90.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 5.1 | 61.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 18.2 | 54.6 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 4.7 | 51.2 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 10.5 | 41.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.5 | 41.9 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 3.7 | 36.8 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 1.6 | 19.1 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.4 | 18.5 | GO:0010390 | histone monoubiquitination(GO:0010390) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 212.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 190.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 32.3 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 32.3 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 31.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 28.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 15.2 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 12.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.4 | 8.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 7.7 | GO:0005840 | ribosome(GO:0005840) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 167.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 8.0 | 96.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.5 | 67.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 1.7 | 50.1 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.4 | 49.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 3.6 | 46.9 | GO:0031386 | protein tag(GO:0031386) |
| 1.8 | 36.8 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 28.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 20.0 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 19.4 | GO:0005521 | lamin binding(GO:0005521) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 54.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.8 | 23.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 19.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 7.7 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.2 | 7.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 5.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 4.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 2.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 371.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 5.0 | 105.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 19.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 11.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 7.7 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 4.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.9 | 3.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 2.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.6 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 0.8 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |