Project

A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for IRF3

Z-value: 4.12

Motif logo

Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_501691320.305.6e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_948803 34.40 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr4_-_169239921 17.56 ENST00000514995.1
ENST00000393743.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr21_+_42792442 16.63 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615570 14.18 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr11_-_615942 13.66 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr10_+_91087651 13.31 ENST00000371818.4
interferon-induced protein with tetratricopeptide repeats 3
chr2_-_163175133 12.93 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr10_+_91092241 11.34 ENST00000371811.4
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_79115503 9.10 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr3_-_122283079 9.00 ENST00000471785.1
ENST00000466126.1
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283100 8.67 ENST00000492382.1
ENST00000462315.1
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283424 8.43 ENST00000477522.2
ENST00000360356.2
poly (ADP-ribose) polymerase family, member 9
chr7_-_92747269 7.98 ENST00000446617.1
ENST00000379958.2
sterile alpha motif domain containing 9
chr12_+_113376157 6.54 ENST00000228928.7
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_+_113376249 6.24 ENST00000551007.1
ENST00000548514.1
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_-_17516449 6.06 ENST00000252593.6
bone marrow stromal cell antigen 2
chr12_+_113416191 5.53 ENST00000342315.4
ENST00000392583.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr9_-_32526184 5.14 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_231084659 5.09 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr3_+_122283175 5.05 ENST00000383661.3
deltex 3-like (Drosophila)
chr9_-_32526299 4.98 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_+_122283064 4.92 ENST00000296161.4
deltex 3-like (Drosophila)
chr7_-_92777606 4.79 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr2_-_231084820 4.44 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr12_+_113416265 4.38 ENST00000449768.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr2_-_37384175 3.72 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
eukaryotic translation initiation factor 2-alpha kinase 2
chr3_+_122399444 3.23 ENST00000474629.2
poly (ADP-ribose) polymerase family, member 14
chr10_+_91061712 3.14 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr4_-_169401628 3.13 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr11_+_5646213 3.09 ENST00000429814.2
tripartite motif containing 34
chr2_-_231084617 2.79 ENST00000409815.2
SP110 nuclear body protein
chr22_+_36649170 2.75 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
apolipoprotein L, 1
chr19_+_10196781 2.72 ENST00000253110.11
chromosome 19 open reading frame 66
chr4_+_89378261 2.71 ENST00000264350.3
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr7_-_139756791 2.45 ENST00000489809.1
poly (ADP-ribose) polymerase family, member 12
chr11_-_57334732 2.22 ENST00000526659.1
ENST00000527022.1
ubiquitin-conjugating enzyme E2L 6
chr14_+_24605389 2.21 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_159706537 2.20 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr19_+_10196981 2.19 ENST00000591813.1
chromosome 19 open reading frame 66
chr12_+_133614062 2.17 ENST00000540031.1
ENST00000536123.1
zinc finger protein 84
chr19_+_49977466 2.03 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
fms-related tyrosine kinase 3 ligand
chr22_+_18632666 1.92 ENST00000215794.7
ubiquitin specific peptidase 18
chr22_+_36649056 1.91 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
apolipoprotein L, 1
chr11_-_57335280 1.85 ENST00000287156.4
ubiquitin-conjugating enzyme E2L 6
chr14_+_24605361 1.81 ENST00000206451.6
ENST00000559123.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_+_113416340 1.79 ENST00000552756.1
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr8_+_26150628 1.74 ENST00000523925.1
ENST00000315985.7
protein phosphatase 2, regulatory subunit B, alpha
chr7_-_944631 1.74 ENST00000453175.2
ArfGAP with dual PH domains 1
chr12_+_133613937 1.56 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
zinc finger protein 84
chr1_-_154580616 1.41 ENST00000368474.4
adenosine deaminase, RNA-specific
chr3_+_122399697 1.37 ENST00000494811.1
poly (ADP-ribose) polymerase family, member 14
chr4_-_74847800 1.33 ENST00000296029.3
platelet factor 4
chr17_+_8316442 1.30 ENST00000582812.1
nudE neurodevelopment protein 1-like 1
chr20_-_47894569 1.27 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
zinc finger, NFX1-type containing 1
chr14_-_24615523 1.22 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_-_99485825 1.20 ENST00000423771.1
KIAA1211-like
chr17_-_40264321 1.20 ENST00000430773.1
ENST00000413196.2
DEXH (Asp-Glu-X-His) box polypeptide 58
chr3_-_123339343 1.13 ENST00000578202.1
myosin light chain kinase
chr4_+_130017268 1.13 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
chromosome 4 open reading frame 33
chr12_+_133613878 1.10 ENST00000392319.2
ENST00000543758.1
zinc finger protein 84
chr17_-_7166500 1.08 ENST00000575313.1
ENST00000397317.4
claudin 7
chr1_+_76190357 1.05 ENST00000370834.5
ENST00000541113.1
ENST00000543667.1
ENST00000420607.2
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr22_+_36044411 1.04 ENST00000409652.4
apolipoprotein L, 6
chr14_-_24615805 0.96 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_-_10022735 0.95 ENST00000228438.2
C-type lectin domain family 2, member B
chr10_+_35416223 0.95 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
cAMP responsive element modulator
chr17_-_40264692 0.95 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_+_35415978 0.93 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
cAMP responsive element modulator
chr1_+_25598872 0.92 ENST00000328664.4
Rh blood group, D antigen
chr11_-_4414880 0.92 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr9_-_100954910 0.85 ENST00000375077.4
coronin, actin binding protein, 2A
chr8_-_67525473 0.84 ENST00000522677.3
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr6_-_36355513 0.79 ENST00000340181.4
ENST00000373737.4
ets variant 7
chr15_-_55611306 0.77 ENST00000563262.1
RAB27A, member RAS oncogene family
chr6_-_2876744 0.77 ENST00000420981.2
RP11-420G6.4
chr10_-_70231639 0.76 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
DNA replication helicase/nuclease 2
chr14_+_73525229 0.75 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RNA binding motif protein 25
chr17_-_30669138 0.73 ENST00000225805.4
ENST00000577809.1
chromosome 17 open reading frame 75
chr2_+_99771418 0.72 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr2_+_69240302 0.72 ENST00000303714.4
anthrax toxin receptor 1
chr6_-_27840099 0.70 ENST00000328488.2
histone cluster 1, H3i
chr5_-_96143796 0.69 ENST00000296754.3
endoplasmic reticulum aminopeptidase 1
chr3_+_184529948 0.67 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr1_-_177939041 0.67 ENST00000308284.6
SEC16 homolog B (S. cerevisiae)
chr15_+_45003675 0.66 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
beta-2-microglobulin
chr3_+_184529929 0.63 ENST00000287546.4
ENST00000437079.3
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr12_+_133614119 0.62 ENST00000327668.7
zinc finger protein 84
chr14_+_73525144 0.61 ENST00000261973.7
ENST00000540173.1
RNA binding motif protein 25
chr14_-_91976874 0.60 ENST00000557018.1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr4_-_87855851 0.59 ENST00000473559.1
chromosome 4 open reading frame 36
chr9_-_95087838 0.54 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
nucleolar protein 8
chrX_+_119384607 0.53 ENST00000326624.2
ENST00000557385.1
zinc finger and BTB domain containing 33
chr12_+_97300995 0.53 ENST00000266742.4
ENST00000429527.2
ENST00000554226.1
ENST00000557478.1
ENST00000557092.1
ENST00000411739.2
ENST00000553609.1
neural precursor cell expressed, developmentally down-regulated 1
chr6_+_26440700 0.51 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
butyrophilin, subfamily 3, member A3
chr6_-_41039567 0.51 ENST00000468811.1
O-acyl-ADP-ribose deacylase 1
chr2_+_207139367 0.50 ENST00000374423.3
zinc finger, DBF-type containing 2
chr11_+_118230287 0.48 ENST00000252108.3
ENST00000431736.2
ubiquitination factor E4A
chr11_+_125461607 0.46 ENST00000527606.1
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr15_+_55611128 0.46 ENST00000164305.5
ENST00000539642.1
phosphatidylinositol glycan anchor biosynthesis, class B
chr16_-_71323271 0.45 ENST00000565850.1
ENST00000568910.1
ENST00000434935.2
ENST00000338099.5
cap methyltransferase 2
chr5_+_77656339 0.43 ENST00000538629.1
secretory carrier membrane protein 1
chr6_-_36355486 0.42 ENST00000538992.1
ets variant 7
chr7_-_138794394 0.42 ENST00000242351.5
ENST00000471652.1
zinc finger CCCH-type, antiviral 1
chr10_-_14996321 0.41 ENST00000378289.4
DNA cross-link repair 1C
chr17_-_63052929 0.40 ENST00000439174.2
guanine nucleotide binding protein (G protein), alpha 13
chr14_+_86401039 0.39 ENST00000557195.1
CTD-2341M24.1
chr16_-_28223229 0.39 ENST00000566073.1
exportin 6
chr6_-_28226984 0.39 ENST00000423974.2
zinc finger with KRAB and SCAN domains 4
chr7_-_138794081 0.37 ENST00000464606.1
zinc finger CCCH-type, antiviral 1
chr9_-_95087604 0.36 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
nucleolar protein 8
chr7_-_32931387 0.36 ENST00000304056.4
kelch repeat and BTB (POZ) domain containing 2
chr1_-_177939348 0.35 ENST00000464631.2
SEC16 homolog B (S. cerevisiae)
chr2_-_214017151 0.34 ENST00000452786.1
IKAROS family zinc finger 2 (Helios)
chr19_+_13051206 0.34 ENST00000586760.1
calreticulin
chr6_+_32821924 0.33 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_121655593 0.33 ENST00000398212.2
TBC1 domain family, member 32
chr2_-_152118352 0.32 ENST00000331426.5
RNA binding motif protein 43
chr14_+_35452104 0.30 ENST00000216774.6
ENST00000546080.1
signal recognition particle 54kDa
chr20_+_46988646 0.30 ENST00000416742.1
ENST00000425021.1
long intergenic non-protein coding RNA 494
chr6_-_32806506 0.30 ENST00000374897.2
ENST00000452392.2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr8_+_22446763 0.28 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
Uncharacterized protein
chr9_+_74764340 0.28 ENST00000376986.1
ENST00000358399.3
guanine deaminase
chr9_+_5450503 0.28 ENST00000381573.4
ENST00000381577.3
CD274 molecule
chr17_-_61517572 0.26 ENST00000582997.1
cytochrome b561
chr6_-_32821599 0.26 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_89664595 0.25 ENST00000355754.6
guanylate binding protein 4
chr2_+_69240415 0.25 ENST00000409829.3
anthrax toxin receptor 1
chr1_+_112298514 0.23 ENST00000536167.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
chr14_+_35452169 0.22 ENST00000555557.1
signal recognition particle 54kDa
chrX_+_146993449 0.22 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
fragile X mental retardation 1
chr15_+_55611401 0.22 ENST00000566999.1
phosphatidylinositol glycan anchor biosynthesis, class B
chr5_-_96143602 0.22 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
endoplasmic reticulum aminopeptidase 1
chr4_-_156875003 0.22 ENST00000433477.3
cathepsin O
chr22_-_36635684 0.18 ENST00000358502.5
apolipoprotein L, 2
chr1_-_146644122 0.18 ENST00000254101.3
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr12_-_322821 0.17 ENST00000359674.4
solute carrier family 6 (neurotransmitter transporter), member 12
chr16_+_75681650 0.16 ENST00000300086.4
telomeric repeat binding factor 2, interacting protein
chr20_-_47894936 0.15 ENST00000371754.4
zinc finger, NFX1-type containing 1
chr4_+_124320665 0.15 ENST00000394339.2
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_+_6659153 0.14 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr12_-_133613794 0.12 ENST00000443154.3
RP11-386I8.6
chrX_+_77154935 0.11 ENST00000481445.1
cytochrome c oxidase subunit VIIb
chr3_-_125802998 0.09 ENST00000514677.1
solute carrier family 41, member 3
chrX_-_109561294 0.08 ENST00000372059.2
ENST00000262844.5
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_-_126892303 0.07 ENST00000358373.3
glutamate receptor, metabotropic 8
chr2_+_219125714 0.07 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
G protein-coupled bile acid receptor 1
chr6_+_28193037 0.06 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
zinc finger and SCAN domain containing 9
chr3_-_160283348 0.06 ENST00000334256.4
karyopherin alpha 4 (importin alpha 3)
chr9_-_95640218 0.06 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
zinc finger protein 484
chr7_-_37382360 0.06 ENST00000455119.1
engulfment and cell motility 1
chr17_+_21729899 0.05 ENST00000583708.1
ubiquitin B pseudogene 4
chr5_+_169758393 0.05 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
chr6_-_110964453 0.04 ENST00000413605.2
cyclin-dependent kinase 19
chr3_+_51977294 0.03 ENST00000498510.1
poly (ADP-ribose) polymerase family, member 3
chr5_-_180288248 0.03 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62 zinc finger protein
chr12_-_8218997 0.02 ENST00000307637.4
complement component 3a receptor 1
chr1_-_11042094 0.02 ENST00000377004.4
ENST00000377008.4
chromosome 1 open reading frame 127
chrX_+_146993534 0.02 ENST00000334557.6
ENST00000439526.2
ENST00000370475.4
fragile X mental retardation 1
chr2_-_190044480 0.01 ENST00000374866.3
collagen, type V, alpha 2
chr6_-_32806483 0.01 ENST00000374899.4
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_+_144434584 0.01 ENST00000283131.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr14_+_73525265 0.01 ENST00000525161.1
RNA binding motif protein 25

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 27.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
5.8 23.0 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
3.4 41.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.3 19.7 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.4 26.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.1 27.8 GO:0035457 cellular response to interferon-alpha(GO:0035457)
2.0 6.1 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
1.1 12.8 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.1 11.7 GO:0018377 protein myristoylation(GO:0018377)
0.9 14.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.8 16.6 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.5 1.4 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.4 3.7 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.3 1.0 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.3 1.0 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.3 2.3 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.2 1.0 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.2 0.9 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 1.3 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.2 1.5 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885) regulation of osteoclast proliferation(GO:0090289)
0.2 10.0 GO:0010390 histone monoubiquitination(GO:0010390)
0.2 0.8 GO:0043504 DNA replication, removal of RNA primer(GO:0043137) mitochondrial DNA repair(GO:0043504) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 0.4 GO:0036451 cap mRNA methylation(GO:0036451)
0.1 0.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 4.7 GO:0019835 cytolysis(GO:0019835)
0.1 0.8 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 1.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.5 GO:0043686 co-translational protein modification(GO:0043686)
0.1 1.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.9 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 1.9 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 0.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 1.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.2 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 4.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 3.1 GO:0070206 protein trimerization(GO:0070206)
0.0 1.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 1.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 1.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.2 GO:0008537 proteasome activator complex(GO:0008537)
0.4 1.3 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.3 1.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.2 1.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 2.2 GO:0031906 late endosome lumen(GO:0031906)
0.2 4.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.7 GO:0031905 early endosome lumen(GO:0031905)
0.1 1.3 GO:0033263 CORVET complex(GO:0033263)
0.1 0.9 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 6.8 GO:0005771 multivesicular body(GO:0005771)
0.1 16.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 11.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 8.7 GO:0005769 early endosome(GO:0005769)
0.0 1.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 32.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 21.9 GO:0010008 endosome membrane(GO:0010008)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 29.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 34.4 GO:0031386 protein tag(GO:0031386)
2.0 24.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.9 26.9 GO:0070403 NAD+ binding(GO:0070403)
0.8 6.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 6.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.6 3.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.4 1.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 42.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.3 2.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.3 1.0 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.2 0.9 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.2 7.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 27.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 6.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.7 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 0.8 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.4 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.7 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.7 GO:0048156 tau protein binding(GO:0048156)
0.1 0.3 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 16.6 GO:0008017 microtubule binding(GO:0008017)
0.0 4.7 GO:0005254 chloride channel activity(GO:0005254)
0.0 10.0 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 3.4 GO:0004386 helicase activity(GO:0004386)
0.0 1.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 1.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 27.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.7 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.7 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 50.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.1 98.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 6.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 5.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 3.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 6.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.8 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor