ISMARA results: IRF3

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 4.12

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Transcription factors associated with IRF3

Gene Symbol	Gene ID	Gene Info
IRF3 Ensembl NCBI GeneCards UniProt	ENSG00000126456.11	interferon regulatory factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF3	hg19_v2_chr19_-_50169064_50169132	0.30	5.6e-01	Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_948803 Show fit	34.40	ENST00000379389.4	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin-like modifier
chr4_-_169239921 Show fit	17.56	ENST00000514995.1 ENST00000393743.3	DDX60 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr21_+_42792442 Show fit	16.63	ENST00000398600.2	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615570 Show fit	14.18	ENST00000525445.1 ENST00000348655.6 ENST00000397566.1	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr11_-_615942 Show fit	13.66	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr10_+_91087651 Show fit	13.31	ENST00000371818.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr2_-_163175133 Show fit	12.93	ENST00000421365.2 ENST00000263642.2	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr10_+_91092241 Show fit	11.34	ENST00000371811.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr1_+_79115503 Show fit	9.10	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 44
chr3_-_122283079 Show fit	9.00	ENST00000471785.1 ENST00000466126.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9

Showing 1 to 10 of 162 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	41.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
9.3	27.8	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
2.1	27.8	GO:0035457	cellular response to interferon-alpha(GO:0035457)
2.4	26.9	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
5.8	23.0	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
3.3	19.7	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.8	16.6	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.9	14.1	GO:0034058	endosomal vesicle fusion(GO:0034058)
1.1	12.8	GO:0060700	regulation of ribonuclease activity(GO:0060700)
1.1	11.7	GO:0018377	protein myristoylation(GO:0018377)

Showing 1 to 10 of 48 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	32.4	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.0	29.8	GO:0005739	mitochondrion(GO:0005739)
0.0	21.9	GO:0010008	endosome membrane(GO:0010008)
0.1	16.7	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	11.2	GO:0005923	bicellular tight junction(GO:0005923)
0.0	8.7	GO:0005769	early endosome(GO:0005769)
0.1	6.8	GO:0005771	multivesicular body(GO:0005771)
1.0	6.2	GO:0008537	proteasome activator complex(GO:0008537)
0.2	4.7	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.2	2.2	GO:0031906	late endosome lumen(GO:0031906)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	42.7	GO:0003725	double-stranded RNA binding(GO:0003725)
2.6	34.4	GO:0031386	protein tag(GO:0031386)
0.2	27.6	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.9	26.9	GO:0070403	NAD+ binding(GO:0070403)
2.0	24.5	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	16.6	GO:0008017	microtubule binding(GO:0008017)
0.0	10.0	GO:0042393	histone binding(GO:0042393)
0.2	7.1	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7	6.8	GO:0042296	ISG15 transferase activity(GO:0042296)
0.8	6.2	GO:0061133	endopeptidase activator activity(GO:0061133)

Showing 1 to 10 of 38 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	27.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	3.7	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.1	2.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	1.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.7	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.7	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	1.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	98.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
2.4	50.9	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	6.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	6.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	5.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	3.8	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	1.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	1.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Showing 1 to 10 of 20 entries

Results for IRF3

Z-value: 4.12

Motif logo

Transcription factors associated with IRF3

Activity-expression correlation:

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: