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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IKZF1
Z-value: 2.27
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Transcription factors associated with IKZF1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_20866424 Show fit | 1.18 |
ENST00000272224.3
|
growth differentiation factor 7 |
|
| chr16_-_28550320 Show fit | 1.14 |
ENST00000395641.2
|
nuclear protein, transcriptional regulator, 1 |
|
| chr19_-_58204128 Show fit | 1.05 |
ENST00000597520.1
|
Uncharacterized protein |
|
| chr19_-_56109119 Show fit | 1.03 |
ENST00000587678.1
|
FLT3-interacting zinc finger 1 |
|
| chr16_+_77246337 Show fit | 0.97 |
ENST00000563157.1
|
synaptonemal complex central element protein 1-like |
|
| chr18_+_20715416 Show fit | 0.97 |
ENST00000580153.1
|
Cdk5 and Abl enzyme substrate 1 |
|
| chr1_+_35247859 Show fit | 0.93 |
ENST00000373362.3
|
gap junction protein, beta 3, 31kDa |
|
| chr19_+_54135310 Show fit | 0.92 |
ENST00000376650.1
|
divergent-paired related homeobox |
|
| chr19_-_19314162 Show fit | 0.90 |
ENST00000420605.3
ENST00000544883.1 ENST00000538165.2 ENST00000331552.7 |
nuclear receptor 2C2-associated protein |
|
| chr17_-_42188598 Show fit | 0.87 |
ENST00000591714.1
|
histone deacetylase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 3.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 2.5 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
| 0.1 | 2.1 | GO:0038065 | collagen-activated signaling pathway(GO:0038065) |
| 0.1 | 2.0 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 2.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 1.8 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.2 | 1.7 | GO:0019075 | virus maturation(GO:0019075) |
| 0.1 | 1.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.1 | 1.7 | GO:2000194 | regulation of female gonad development(GO:2000194) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0005924 | cell-substrate adherens junction(GO:0005924) |
| 0.0 | 4.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 3.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 2.8 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 2.7 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 2.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 2.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 2.3 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 2.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 2.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 2.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 2.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.5 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 2.5 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 2.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 2.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 2.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 2.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 2.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 4.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 3.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 3.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.8 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 2.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |