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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HSF4
Z-value: 1.11
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Transcription factors associated with HSF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF4 | hg19_v2_chr16_+_67198683_67198715 | -0.73 | 9.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_228678550 Show fit | 1.08 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr13_-_31736132 Show fit | 0.89 |
ENST00000429785.2
|
heat shock 105kDa/110kDa protein 1 |
|
| chr14_-_102553371 Show fit | 0.69 |
ENST00000553585.1
ENST00000216281.8 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 |
|
| chr17_+_45401308 Show fit | 0.68 |
ENST00000331493.2
ENST00000519772.1 ENST00000517484.1 |
EF-hand calcium binding domain 13 |
|
| chr13_-_31736478 Show fit | 0.64 |
ENST00000445273.2
|
heat shock 105kDa/110kDa protein 1 |
|
| chr7_-_139763521 Show fit | 0.63 |
ENST00000263549.3
|
poly (ADP-ribose) polymerase family, member 12 |
|
| chr6_-_106773291 Show fit | 0.60 |
ENST00000343245.3
|
autophagy related 5 |
|
| chr1_+_92683467 Show fit | 0.58 |
ENST00000370375.3
ENST00000370373.2 |
chromosome 1 open reading frame 146 |
|
| chrX_+_123094672 Show fit | 0.57 |
ENST00000354548.5
ENST00000458700.1 |
stromal antigen 2 |
|
| chr7_+_26240776 Show fit | 0.57 |
ENST00000337620.4
|
chromobox homolog 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.1 | GO:1903751 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.1 | 1.3 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.0 | 1.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.4 | 1.1 | GO:0042222 | interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 1.1 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.2 | 0.9 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.1 | 0.9 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 0.8 | GO:0002840 | T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) |
| 0.0 | 0.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 0.7 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 1.2 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 1.1 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 0.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 0.7 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.6 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.0 | 0.6 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 0.5 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.1 | 0.5 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.1 | 0.5 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 1.7 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 1.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.4 | 1.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 1.0 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.1 | 0.9 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 0.9 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 0.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.6 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.1 | 0.6 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.1 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.3 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |