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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HSF1
Z-value: 0.98
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Transcription factors associated with HSF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF1 | hg19_v2_chr8_+_145515263_145515299 | 0.22 | 6.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_139847347 Show fit | 0.65 |
ENST00000371632.3
|
lipocalin 12 |
|
| chr19_+_3762703 Show fit | 0.59 |
ENST00000589174.1
|
mitochondrial ribosomal protein L54 |
|
| chr2_-_27851745 Show fit | 0.43 |
ENST00000394775.3
ENST00000522876.1 |
coiled-coil domain containing 121 |
|
| chr19_+_8740061 Show fit | 0.42 |
ENST00000593792.1
|
CTD-2586B10.1 |
|
| chrX_+_49020882 Show fit | 0.39 |
ENST00000454342.1
|
MAGI family member, X-linked |
|
| chr19_+_917287 Show fit | 0.38 |
ENST00000592648.1
ENST00000234371.5 |
KISS1 receptor |
|
| chr7_-_139763521 Show fit | 0.37 |
ENST00000263549.3
|
poly (ADP-ribose) polymerase family, member 12 |
|
| chr1_+_35247859 Show fit | 0.37 |
ENST00000373362.3
|
gap junction protein, beta 3, 31kDa |
|
| chr19_+_1354930 Show fit | 0.35 |
ENST00000591337.1
|
melanoma associated antigen (mutated) 1 |
|
| chr17_+_78193443 Show fit | 0.34 |
ENST00000577155.1
|
solute carrier family 26 (anion exchanger), member 11 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.0 | 0.5 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.0 | 0.4 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 0.3 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.1 | 0.3 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.0 | 0.3 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.3 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.0 | 0.3 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.1 | 0.2 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) |
| 0.1 | 0.2 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.1 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.0 | 0.1 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 0.1 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.0 | 0.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.1 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.4 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.0 | 0.3 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.0 | 0.3 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.0 | 0.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.2 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 0.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.0 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |