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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD11_HOXA11

Z-value: 0.78

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Transcription factors associated with HOXD11_HOXA11

Gene Symbol Gene ID Gene Info
ENSG00000128713.11 homeobox D11
ENSG00000005073.5 homeobox A11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA11hg19_v2_chr7_-_27224842_272248720.731.0e-01Click!
HOXD11hg19_v2_chr2_+_176972000_176972025-0.582.2e-01Click!

Activity profile of HOXD11_HOXA11 motif

Sorted Z-values of HOXD11_HOXA11 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_107650219 1.14 ENST00000398067.1
Uncharacterized protein
chr14_+_39944025 0.89 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
chr5_-_159766528 0.74 ENST00000505287.2
cyclin J-like
chr12_+_54384370 0.57 ENST00000504315.1
homeobox C6
chr6_-_27775694 0.53 ENST00000377401.2
histone cluster 1, H2bl
chr1_+_202385953 0.51 ENST00000466968.1
protein phosphatase 1, regulatory subunit 12B
chr2_+_138722028 0.49 ENST00000280096.5
histamine N-methyltransferase
chr5_+_35852797 0.49 ENST00000508941.1
interleukin 7 receptor
chr19_-_10420459 0.46 ENST00000403352.1
ENST00000403903.3
zinc finger, GATA-like protein 1
chr10_+_102222798 0.44 ENST00000343737.5
wingless-type MMTV integration site family, member 8B
chr1_-_12679171 0.44 ENST00000606790.1
RP11-474O21.5
chr6_-_121655850 0.42 ENST00000422369.1
TBC1 domain family, member 32
chr13_-_46626820 0.42 ENST00000428921.1
zinc finger CCCH-type containing 13
chr15_+_76352178 0.40 ENST00000388942.3
chromosome 15 open reading frame 27
chr8_+_101349823 0.38 ENST00000519566.1
KB-1991G8.1
chr12_-_49418407 0.37 ENST00000526209.1
lysine (K)-specific methyltransferase 2D
chr12_+_52056548 0.36 ENST00000545061.1
ENST00000355133.3
sodium channel, voltage gated, type VIII, alpha subunit
chr12_-_112443767 0.35 ENST00000550233.1
ENST00000546962.1
ENST00000550800.2
transmembrane protein 116
chr11_-_111649074 0.33 ENST00000534218.1
RP11-108O10.2
chr16_-_21863541 0.32 ENST00000543654.1
nuclear pore complex interacting protein family, member B4
chr8_-_1922789 0.32 ENST00000521498.1
RP11-439C15.4
chr14_-_25479811 0.31 ENST00000550887.1
syntaxin binding protein 6 (amisyn)
chr3_+_167582561 0.31 ENST00000463642.1
ENST00000464514.1
RP11-298O21.6
RP11-298O21.7
chr12_-_6579833 0.30 ENST00000396308.3
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr6_+_12007963 0.30 ENST00000607445.1
RP11-456H18.2
chr17_+_7211656 0.30 ENST00000416016.2
eukaryotic translation initiation factor 5A
chr12_-_71148413 0.29 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
protein tyrosine phosphatase, receptor type, R
chr6_-_15548591 0.29 ENST00000509674.1
dystrobrevin binding protein 1
chr5_+_121465234 0.28 ENST00000504912.1
ENST00000505843.1
zinc finger protein 474
chr5_-_135290705 0.28 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr6_+_26199737 0.28 ENST00000359985.1
histone cluster 1, H2bf
chr16_+_19619083 0.28 ENST00000538552.1
chromosome 16 open reading frame 62
chr12_+_6833323 0.28 ENST00000544725.1
COP9 signalosome subunit 7A
chr18_+_68002675 0.28 ENST00000584919.1
Uncharacterized protein
chr11_+_63606373 0.28 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MAP/microtubule affinity-regulating kinase 2
chrX_+_1455668 0.28 ENST00000432757.1
interleukin 3 receptor, alpha (low affinity)
chr13_-_47471155 0.27 ENST00000543956.1
ENST00000542664.1
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr2_-_160568529 0.27 ENST00000418770.1
AC009961.3
chr11_+_115498761 0.27 ENST00000424313.2
AP000997.1
chrY_+_15418467 0.27 ENST00000595988.1
Uncharacterized protein
chr12_+_130646999 0.26 ENST00000539839.1
ENST00000229030.4
frizzled family receptor 10
chr4_+_169633310 0.26 ENST00000510998.1
palladin, cytoskeletal associated protein
chr11_+_76745385 0.26 ENST00000533140.1
ENST00000354301.5
ENST00000528622.1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr14_-_92247032 0.26 ENST00000556661.1
ENST00000553676.1
ENST00000554560.1
catsper channel auxiliary subunit beta
chr19_-_45982076 0.25 ENST00000423698.2
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr16_-_21663950 0.25 ENST00000268389.4
immunoglobulin superfamily, member 6
chr11_-_47447970 0.25 ENST00000298852.3
ENST00000530912.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr1_+_62439037 0.25 ENST00000545929.1
InaD-like (Drosophila)
chr2_+_109204743 0.25 ENST00000332345.6
LIM and senescent cell antigen-like domains 1
chr6_+_131958436 0.25 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr2_+_97454321 0.24 ENST00000540067.1
cyclin M4
chr9_+_2029019 0.24 ENST00000382194.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_219615984 0.24 ENST00000420762.1
RP11-95P13.1
chr9_+_105757590 0.24 ENST00000374798.3
ENST00000487798.1
cylicin, basic protein of sperm head cytoskeleton 2
chr3_+_140981456 0.23 ENST00000504264.1
acid phosphatase-like 2
chr10_+_96698406 0.23 ENST00000260682.6
cytochrome P450, family 2, subfamily C, polypeptide 9
chr13_-_30951282 0.23 ENST00000420219.1
long intergenic non-protein coding RNA 426
chr17_-_46690839 0.23 ENST00000498634.2
homeobox B8
chr7_-_69062391 0.23 ENST00000436600.2
RP5-942I16.1
chr17_+_75369400 0.23 ENST00000590059.1
septin 9
chr2_-_228497888 0.23 ENST00000264387.4
ENST00000409066.1
chromosome 2 open reading frame 83
chr2_+_220306238 0.23 ENST00000435853.1
SPEG complex locus
chr12_-_14924056 0.23 ENST00000539745.1
histone cluster 4, H4
chr12_-_25348007 0.23 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
cancer susceptibility candidate 1
chr11_-_1606513 0.23 ENST00000382171.2
keratin associated protein 5-1
chr12_-_62586543 0.23 ENST00000416284.3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr1_+_6640108 0.23 ENST00000377674.4
ENST00000488936.1
zinc finger and BTB domain containing 48
chr6_+_42584847 0.23 ENST00000372883.3
ubiquitin protein ligase E3 component n-recognin 2
chr3_+_15045419 0.23 ENST00000406272.2
nuclear receptor subfamily 2, group C, member 2
chr12_+_6833437 0.23 ENST00000534947.1
ENST00000541866.1
ENST00000534877.1
ENST00000538753.1
COP9 signalosome subunit 7A
chr1_-_151148442 0.23 ENST00000441701.1
ENST00000416280.2
tropomodulin 4 (muscle)
chr9_-_28670283 0.22 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chr3_-_112127981 0.22 ENST00000486726.2
RP11-231E6.1
chr10_+_24755416 0.22 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr11_+_72983246 0.22 ENST00000393590.2
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr14_+_105864847 0.22 ENST00000451127.2
testis expressed 22
chr2_+_158114051 0.22 ENST00000259056.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr5_+_148521454 0.22 ENST00000508983.1
actin binding LIM protein family, member 3
chr1_+_229440129 0.22 ENST00000366688.3
S-phase response (cyclin related)
chr11_-_796197 0.21 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr10_-_10504285 0.21 ENST00000602311.1
RP11-271F18.4
chr7_+_138915102 0.21 ENST00000486663.1
ubinuclein 2
chr4_-_85654615 0.21 ENST00000514711.1
WD repeat and FYVE domain containing 3
chr16_-_4852915 0.21 ENST00000322048.7
rogdi homolog (Drosophila)
chr9_-_16705069 0.21 ENST00000471301.2
basonuclin 2
chrX_-_135962923 0.21 ENST00000565438.1
RNA binding motif protein, X-linked
chr4_+_76439095 0.21 ENST00000506261.1
THAP domain containing 6
chr15_-_85197501 0.20 ENST00000434634.2
WD repeat domain 73
chr2_+_28618532 0.20 ENST00000545753.1
FOS-like antigen 2
chr1_-_168464875 0.20 ENST00000422253.1
RP5-968D22.3
chr2_-_111230393 0.19 ENST00000447537.2
ENST00000413601.2
LIM and senescent cell antigen-like-containing domain protein 3; Uncharacterized protein; cDNA FLJ59124, highly similar to Particularly interesting newCys-His protein; cDNA, FLJ79109, highly similar to Particularly interesting newCys-His protein
LIM and senescent cell antigen-like domains 3-like
chr3_+_169629354 0.19 ENST00000428432.2
ENST00000335556.3
sterile alpha motif domain containing 7
chr8_+_9009202 0.19 ENST00000518496.1
Uncharacterized protein
chr5_-_86534822 0.19 ENST00000445770.2
Uncharacterized protein
chr4_-_84035905 0.18 ENST00000311507.4
placenta-specific 8
chrX_+_1455478 0.18 ENST00000331035.4
interleukin 3 receptor, alpha (low affinity)
chr12_-_71148357 0.18 ENST00000378778.1
protein tyrosine phosphatase, receptor type, R
chr20_+_30102231 0.18 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
histocompatibility (minor) 13
chr14_+_73706308 0.18 ENST00000554301.1
ENST00000555445.1
papilin, proteoglycan-like sulfated glycoprotein
chrX_+_37865804 0.18 ENST00000297875.2
ENST00000357972.5
synaptotagmin-like 5
chr11_-_74204692 0.18 ENST00000528085.1
lipoyl(octanoyl) transferase 2 (putative)
chr10_+_127661942 0.18 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
fibronectin type III and ankyrin repeat domains 1
chr7_+_23719749 0.18 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
family with sequence similarity 221, member A
chr10_+_85933494 0.18 ENST00000372126.3
chromosome 10 open reading frame 99
chr15_-_101817492 0.17 ENST00000528346.1
ENST00000531964.1
VCP-interacting membrane protein
chr14_-_20774092 0.17 ENST00000423949.2
ENST00000553828.1
ENST00000258821.3
tetratricopeptide repeat domain 5
chr15_-_99789736 0.17 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
tetratricopeptide repeat domain 23
chr17_-_39684550 0.17 ENST00000455635.1
ENST00000361566.3
keratin 19
chr6_+_148593425 0.17 ENST00000367469.1
SAM and SH3 domain containing 1
chr8_-_133772870 0.17 ENST00000522334.1
ENST00000519016.1
transmembrane protein 71
chr10_-_90751038 0.17 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
actin, alpha 2, smooth muscle, aorta
chr16_+_15031300 0.17 ENST00000328085.6
nuclear pore complex interacting protein family, member A1
chr2_+_109204909 0.17 ENST00000393310.1
LIM and senescent cell antigen-like domains 1
chr12_+_70219052 0.17 ENST00000552032.2
ENST00000547771.2
myelin regulatory factor-like
chr9_-_26892765 0.17 ENST00000520187.1
ENST00000333916.5
caspase activity and apoptosis inhibitor 1
chr19_-_10446449 0.17 ENST00000592439.1
intercellular adhesion molecule 3
chr10_+_118608998 0.17 ENST00000409522.1
ENST00000341276.5
ENST00000512864.2
enolase family member 4
chr4_+_124571409 0.17 ENST00000514823.1
ENST00000511919.1
ENST00000508111.1
long intergenic non-protein coding RNA 1091
chr12_-_6580094 0.17 ENST00000361716.3
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr4_-_110723194 0.16 ENST00000394635.3
complement factor I
chr1_+_92545862 0.16 ENST00000370382.3
ENST00000342818.3
BTB (POZ) domain containing 8
chr4_+_186317133 0.16 ENST00000507753.1
ankyrin repeat domain 37
chr9_+_131085095 0.16 ENST00000372875.3
coenzyme Q4
chr3_-_9921934 0.16 ENST00000423850.1
cell death-inducing DFFA-like effector c
chr1_+_174670143 0.16 ENST00000367687.1
ENST00000347255.2
RAB GTPase activating protein 1-like
chrX_-_15332665 0.16 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr15_+_67418047 0.16 ENST00000540846.2
SMAD family member 3
chr12_+_58087738 0.16 ENST00000552285.1
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr12_+_76653611 0.16 ENST00000550380.1
RP11-54A9.1
chr19_-_33182616 0.16 ENST00000592431.1
CTD-2538C1.2
chr8_+_77318769 0.16 ENST00000518732.1
long intergenic non-protein coding RNA 1111
chr10_+_47894023 0.16 ENST00000358474.5
family with sequence similarity 21, member B
chr3_-_196242233 0.16 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chr1_+_150898812 0.16 ENST00000271640.5
ENST00000448029.1
ENST00000368962.2
ENST00000534805.1
ENST00000368969.4
ENST00000368963.1
ENST00000498193.1
SET domain, bifurcated 1
chr1_+_181057638 0.15 ENST00000367577.4
immediate early response 5
chr2_-_217236750 0.15 ENST00000273067.4
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
chr13_-_24476794 0.15 ENST00000382140.2
C1q and tumor necrosis factor related protein 9B
chr1_+_154401791 0.15 ENST00000476006.1
interleukin 6 receptor
chr6_-_27782548 0.15 ENST00000333151.3
histone cluster 1, H2aj
chr12_+_6833237 0.15 ENST00000229251.3
ENST00000539735.1
ENST00000538410.1
COP9 signalosome subunit 7A
chr17_+_61086917 0.15 ENST00000424789.2
ENST00000389520.4
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr13_-_24471194 0.15 ENST00000382137.3
ENST00000382057.3
C1q and tumor necrosis factor related protein 9B
chr12_+_76653682 0.15 ENST00000553247.1
RP11-54A9.1
chr7_+_79998864 0.15 ENST00000435819.1
CD36 molecule (thrombospondin receptor)
chr10_-_61899124 0.15 ENST00000373815.1
ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_54230819 0.15 ENST00000318698.2
ENST00000566473.2
ankyrin-repeat and fibronectin type III domain containing 1
chr10_+_135160844 0.15 ENST00000423766.1
ENST00000458230.1
proline-rich acidic protein 1
chr10_-_129691195 0.14 ENST00000368671.3
clarin 3
chr11_-_47447767 0.14 ENST00000530651.1
ENST00000524447.2
ENST00000531051.2
ENST00000526993.1
ENST00000602866.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr17_-_27188984 0.14 ENST00000582320.2
microRNA 451b
chr5_-_111093759 0.14 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
neuronal regeneration related protein
chr22_-_30642782 0.14 ENST00000249075.3
leukemia inhibitory factor
chr9_+_116263778 0.14 ENST00000394646.3
regulator of G-protein signaling 3
chr7_-_130080977 0.14 ENST00000223208.5
centrosomal protein 41kDa
chr11_+_126173647 0.14 ENST00000263579.4
decapping enzyme, scavenger
chr8_+_94752349 0.14 ENST00000391680.1
RBM12B antisense RNA 1
chr5_+_121465207 0.14 ENST00000296600.4
zinc finger protein 474
chr9_-_75488984 0.14 ENST00000423171.1
ENST00000449235.1
ENST00000453787.1
RP11-151D14.1
chr6_+_158733692 0.14 ENST00000367094.2
ENST00000367097.3
tubby like protein 4
chr2_+_133874577 0.14 ENST00000596384.1
HCG2006742; Protein LOC100996685
chr15_-_66797172 0.14 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
ribosomal protein L4
chr8_-_38326139 0.14 ENST00000335922.5
ENST00000532791.1
ENST00000397091.5
fibroblast growth factor receptor 1
chr4_-_76957214 0.14 ENST00000306621.3
chemokine (C-X-C motif) ligand 11
chr7_+_128784712 0.14 ENST00000289407.4
tetraspanin 33
chr8_-_38326119 0.14 ENST00000356207.5
ENST00000326324.6
fibroblast growth factor receptor 1
chr19_-_19626838 0.14 ENST00000360913.3
testis-specific serine kinase 6
chr1_-_89641680 0.14 ENST00000294671.2
guanylate binding protein 7
chr9_+_101705893 0.14 ENST00000375001.3
collagen, type XV, alpha 1
chr12_+_58087901 0.14 ENST00000315970.7
ENST00000547079.1
ENST00000439210.2
ENST00000389146.6
ENST00000413095.2
ENST00000551035.1
ENST00000257966.8
ENST00000435406.2
ENST00000550372.1
ENST00000389142.5
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr9_+_131084815 0.14 ENST00000300452.3
ENST00000609948.1
coenzyme Q4
chrX_+_78003204 0.14 ENST00000435339.3
ENST00000514744.1
lysophosphatidic acid receptor 4
chr7_+_73106926 0.13 ENST00000453316.1
Williams Beuren syndrome chromosome region 22
chr5_-_94417186 0.13 ENST00000312216.8
ENST00000512425.1
multiple C2 domains, transmembrane 1
chr15_+_69857515 0.13 ENST00000559477.1
RP11-279F6.1
chr12_+_43086018 0.13 ENST00000550177.1
RP11-25I15.3
chr17_-_48450534 0.13 ENST00000503633.1
ENST00000442592.3
ENST00000225969.4
mitochondrial ribosomal protein L27
chr6_-_136788001 0.13 ENST00000544465.1
microtubule-associated protein 7
chr3_-_52188397 0.13 ENST00000474012.1
ENST00000296484.2
POC1 centriolar protein A
chr9_+_131549610 0.13 ENST00000223865.8
TBC1 domain family, member 13
chr3_+_111260980 0.13 ENST00000438817.2
CD96 molecule
chr8_+_77593448 0.13 ENST00000521891.2
zinc finger homeobox 4
chr13_+_24844857 0.13 ENST00000409126.1
ENST00000343003.6
spermatogenesis associated 13
chr11_+_64001962 0.13 ENST00000309422.2
vascular endothelial growth factor B
chr5_-_36301984 0.13 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RAN binding protein 3-like
chrX_+_56590002 0.13 ENST00000338222.5
ubiquilin 2
chr9_-_98189055 0.13 ENST00000433644.2
RP11-435O5.2
chr19_+_41281060 0.13 ENST00000594436.1
ENST00000597784.1
melanoma inhibitory activity
chr3_-_57326704 0.13 ENST00000487349.1
ENST00000389601.3
ankyrin repeat and SOCS box containing 14
chr6_-_131211534 0.13 ENST00000456097.2
erythrocyte membrane protein band 4.1-like 2
chr9_-_130889990 0.13 ENST00000449878.1
prostaglandin E synthase 2
chr8_-_73793975 0.13 ENST00000523881.1
RP11-1145L24.1
chrX_-_30595959 0.12 ENST00000378962.3
chromosome X open reading frame 21
chr3_-_151176497 0.12 ENST00000282466.3
immunoglobulin superfamily, member 10
chr14_+_56584414 0.12 ENST00000559044.1
pellino E3 ubiquitin protein ligase family member 2
chr16_-_30381580 0.12 ENST00000409939.3
TBC1 domain family, member 10B
chr1_+_227127981 0.12 ENST00000366778.1
ENST00000366777.3
ENST00000458507.2
aarF domain containing kinase 3
chr11_+_19798964 0.12 ENST00000527559.2
neuron navigator 2
chr17_+_66521936 0.12 ENST00000592800.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr11_-_65359947 0.12 ENST00000597463.1
Uncharacterized protein
chr1_+_52682052 0.12 ENST00000371591.1
zinc finger, FYVE domain containing 9

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1903465 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.5 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1 0.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.3 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.4 GO:0001555 oocyte growth(GO:0001555)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.2 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.1 0.2 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.1 0.3 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.2 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.2 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.3 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.3 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.2 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 0.2 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.3 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.1 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.2 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.3 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:1903988 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.0 0.1 GO:0006566 threonine metabolic process(GO:0006566)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.2 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.3 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.0 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.1 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.0 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:0042701 progesterone secretion(GO:0042701) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.3 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.2 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.0 0.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0030047 actin modification(GO:0030047)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.0 GO:0072616 interleukin-18 secretion(GO:0072616)
0.0 0.1 GO:0001507 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.1 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.4 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.0 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.0 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.0 0.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.0 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.0 0.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.0 GO:1903566 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.0 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:0006096 glycolytic process(GO:0006096)
0.0 0.0 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.0 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.1 GO:0033029 neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.5 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.5 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0046098 guanine metabolic process(GO:0046098)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.0 GO:0005902 microvillus(GO:0005902)
0.0 0.1 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.3 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.1 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.2 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.3 GO:0035529 phosphodiesterase I activity(GO:0004528) NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.2 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.4 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.0 0.1 GO:0019115 benzaldehyde dehydrogenase activity(GO:0019115)
0.0 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.1 GO:0097689 iron channel activity(GO:0097689)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.0 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.0 0.0 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.0 0.0 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0004423 iduronate-2-sulfatase activity(GO:0004423)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.0 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease