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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXB2_UNCX_HOXD3
Z-value: 1.03
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Transcription factors associated with HOXB2_UNCX_HOXD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD3 | hg19_v2_chr2_+_177001685_177001685 | -0.65 | 1.6e-01 | Click! |
| UNCX | hg19_v2_chr7_+_1272522_1272543 | -0.09 | 8.7e-01 | Click! |
| HOXB2 | hg19_v2_chr17_-_46623441_46623441 | -0.02 | 9.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB2_UNCX_HOXD3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 2.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.6 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion(GO:0034116) |
| 0.3 | 1.3 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.0 | 1.2 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 1.1 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 1.0 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.3 | 0.9 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.1 | 0.9 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.3 | 0.8 | GO:1903718 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.6 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 1.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.0 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 1.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.9 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 0.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.7 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.6 | GO:0045180 | basal cortex(GO:0045180) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.1 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 1.0 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 0.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.2 | 0.8 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.2 | 0.8 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.0 | 0.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.7 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.2 | 0.6 | GO:0035248 | alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248) |
| 0.2 | 0.6 | GO:0019781 | NEDD8 activating enzyme activity(GO:0019781) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 1.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.0 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 0.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.5 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |