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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA4

Z-value: 0.46

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
HOXA4
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27170352_27170418-0.503.1e-01Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_66918558 0.71 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr5_-_38557561 0.28 ENST00000511561.1
LIFR
leukemia inhibitory factor receptor alpha
chr3_-_52486841 0.26 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr5_+_133562095 0.24 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr14_+_59100774 0.24 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr20_+_32150140 0.23 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr12_-_120241187 0.20 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr15_+_89631647 0.19 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr1_-_12677714 0.18 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr12_-_86650077 0.18 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_+_177015950 0.18 ENST00000306324.3
HOXD4
homeobox D4
chr6_-_31514516 0.17 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr1_+_28586006 0.17 ENST00000253063.3
SESN2
sestrin 2
chr10_+_77056181 0.16 ENST00000526759.1
ENST00000533822.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr6_+_63921399 0.16 ENST00000356170.3
FKBP1C
FK506 binding protein 1C
chr18_-_56985776 0.15 ENST00000587244.1
CPLX4
complexin 4
chr18_-_658244 0.14 ENST00000585033.1
ENST00000323813.3
C18orf56
chromosome 18 open reading frame 56
chr3_-_178984759 0.14 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr5_+_159343688 0.13 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chrX_+_37639264 0.13 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr2_-_187367356 0.13 ENST00000595956.1
AC018867.2
AC018867.2
chr7_-_14029283 0.12 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr5_+_150406527 0.12 ENST00000520059.1
GPX3
glutathione peroxidase 3 (plasma)
chr11_-_62313090 0.12 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr8_+_71383312 0.12 ENST00000520259.1
RP11-333A23.4
RP11-333A23.4
chr8_+_77593448 0.12 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr19_-_893200 0.12 ENST00000269814.4
ENST00000395808.3
ENST00000312090.6
ENST00000325464.1
MED16
mediator complex subunit 16
chr2_-_43453734 0.12 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr17_-_77924627 0.12 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr1_-_204329013 0.12 ENST00000272203.3
ENST00000414478.1
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr9_-_16276311 0.11 ENST00000380685.1
C9orf92
chromosome 9 open reading frame 92
chr17_+_54230819 0.11 ENST00000318698.2
ENST00000566473.2
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr10_-_92681033 0.11 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr21_+_17909594 0.11 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr7_+_100273736 0.10 ENST00000412215.1
ENST00000393924.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr9_-_16253112 0.10 ENST00000380683.1
C9orf92
chromosome 9 open reading frame 92
chr20_+_57464200 0.10 ENST00000604005.1
GNAS
GNAS complex locus
chrX_+_37639302 0.10 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr1_-_156460391 0.10 ENST00000360595.3
MEF2D
myocyte enhancer factor 2D
chr3_+_159557637 0.09 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr8_+_77593474 0.09 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr5_+_66300464 0.09 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr15_+_89631381 0.09 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr1_+_170632250 0.09 ENST00000367760.3
PRRX1
paired related homeobox 1
chr12_-_11091862 0.09 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr10_-_106240032 0.09 ENST00000447860.1
RP11-127O4.3
RP11-127O4.3
chr15_+_75080883 0.09 ENST00000567571.1
CSK
c-src tyrosine kinase
chr5_+_140810132 0.09 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr11_+_128563652 0.08 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr15_-_33447055 0.08 ENST00000559047.1
ENST00000561249.1
FMN1
formin 1
chr5_+_60933634 0.08 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr19_-_1021113 0.08 ENST00000333175.5
ENST00000356663.3
TMEM259
transmembrane protein 259
chr6_+_100054606 0.08 ENST00000369215.4
PRDM13
PR domain containing 13
chr17_+_73452545 0.08 ENST00000314256.7
KIAA0195
KIAA0195
chr6_-_116447283 0.07 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr19_+_12949251 0.07 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr3_-_57233966 0.07 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr1_-_42384343 0.07 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chrX_-_55024967 0.07 ENST00000545676.1
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_+_167298281 0.07 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr1_-_159832438 0.07 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr15_+_51669513 0.07 ENST00000558426.1
GLDN
gliomedin
chr5_+_140535577 0.06 ENST00000539533.1
PCDHB17
Protocadherin-psi1; Uncharacterized protein
chr4_-_185139062 0.06 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr12_+_56522001 0.06 ENST00000267113.4
ENST00000541590.1
ESYT1
extended synaptotagmin-like protein 1
chr6_+_63921351 0.06 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr6_-_26235206 0.06 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr12_+_56521840 0.06 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr2_+_54683419 0.06 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr12_+_29376592 0.06 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr3_+_188664988 0.06 ENST00000433971.1
TPRG1
tumor protein p63 regulated 1
chr4_-_109541539 0.05 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr4_-_109541610 0.05 ENST00000510212.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr6_+_31514622 0.05 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr12_+_53848549 0.05 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr14_+_37131058 0.05 ENST00000361487.6
PAX9
paired box 9
chr7_+_18330035 0.05 ENST00000413509.2
HDAC9
histone deacetylase 9
chr17_-_2117600 0.05 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr12_-_86650045 0.05 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr12_+_29376673 0.05 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr2_+_39117010 0.05 ENST00000409978.1
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr6_-_116833500 0.04 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr17_-_67138015 0.04 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_+_69134124 0.04 ENST00000478935.1
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr18_-_53019208 0.04 ENST00000562607.1
TCF4
transcription factor 4
chr2_-_190927447 0.04 ENST00000260950.4
MSTN
myostatin
chr10_-_101825151 0.04 ENST00000441382.1
CPN1
carboxypeptidase N, polypeptide 1
chr7_-_14026123 0.04 ENST00000420159.2
ENST00000399357.3
ENST00000403527.1
ETV1
ets variant 1
chr7_+_141418962 0.04 ENST00000493845.1
WEE2
WEE1 homolog 2 (S. pombe)
chr17_-_38928414 0.04 ENST00000335552.4
KRT26
keratin 26
chr18_+_13612613 0.04 ENST00000586765.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr10_-_33623310 0.04 ENST00000395995.1
ENST00000374823.5
ENST00000374821.5
ENST00000374816.3
NRP1
neuropilin 1
chrX_+_41548259 0.04 ENST00000378138.5
GPR34
G protein-coupled receptor 34
chr10_-_101690650 0.04 ENST00000543621.1
DNMBP
dynamin binding protein
chr8_-_42358742 0.03 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr8_+_39792474 0.03 ENST00000502986.2
IDO2
indoleamine 2,3-dioxygenase 2
chr18_-_70532906 0.03 ENST00000299430.2
ENST00000397929.1
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr6_+_152011628 0.03 ENST00000404742.1
ENST00000440973.1
ESR1
estrogen receptor 1
chr16_+_67280799 0.03 ENST00000566345.2
SLC9A5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chrX_-_19689106 0.03 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr4_-_152147579 0.03 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr19_-_10047219 0.02 ENST00000264833.4
OLFM2
olfactomedin 2
chr12_-_68845165 0.02 ENST00000360485.3
ENST00000441255.2
RP11-81H14.2
RP11-81H14.2
chr11_+_124481361 0.02 ENST00000284288.2
PANX3
pannexin 3
chr7_-_29234802 0.02 ENST00000449801.1
ENST00000409850.1
CPVL
carboxypeptidase, vitellogenic-like
chr7_+_117251671 0.02 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr7_+_7811992 0.02 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr12_+_53848505 0.02 ENST00000552819.1
ENST00000455667.3
PCBP2
poly(rC) binding protein 2
chr11_+_27062860 0.02 ENST00000528583.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr7_-_14026063 0.02 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr1_+_245318279 0.02 ENST00000407071.2
KIF26B
kinesin family member 26B
chr2_+_87135076 0.02 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr7_+_32996997 0.02 ENST00000242209.4
ENST00000538336.1
ENST00000538443.1
FKBP9
FK506 binding protein 9, 63 kDa
chr10_-_105845674 0.02 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr5_-_13944652 0.01 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr1_+_214161272 0.01 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr20_-_45035223 0.01 ENST00000450812.1
ENST00000290246.6
ENST00000439931.2
ENST00000396391.1
ELMO2
engulfment and cell motility 2
chr5_+_40909354 0.01 ENST00000313164.9
C7
complement component 7
chr11_+_120971882 0.01 ENST00000392793.1
TECTA
tectorin alpha
chrX_+_41548220 0.01 ENST00000378142.4
GPR34
G protein-coupled receptor 34
chr17_-_48785216 0.01 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr9_+_75263565 0.01 ENST00000396237.3
TMC1
transmembrane channel-like 1
chrX_+_129473916 0.01 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr5_+_115387163 0.01 ENST00000601302.2
ARL14EPL
ADP-ribosylation factor-like 14 effector protein-like
chr3_-_129513259 0.01 ENST00000329333.5
TMCC1
transmembrane and coiled-coil domain family 1
chr19_-_42806919 0.01 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr12_+_106976678 0.01 ENST00000392842.1
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr12_-_57037284 0.00 ENST00000551570.1
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr6_-_55740352 0.00 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr4_-_66536057 0.00 ENST00000273854.3
EPHA5
EPH receptor A5
chr8_+_22424551 0.00 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr12_+_50144381 0.00 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr10_-_75415825 0.00 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr2_-_80531824 0.00 ENST00000295057.3
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr2_-_80531399 0.00 ENST00000409148.1
ENST00000415098.1
ENST00000452811.1
LRRTM1
leucine rich repeat transmembrane neuronal 1
chrX_+_129473859 0.00 ENST00000424447.1
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_-_100643765 0.00 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
LRRC39
leucine rich repeat containing 39
chr21_+_22370717 0.00 ENST00000284894.7
NCAM2
neural cell adhesion molecule 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.2 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.3 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.2 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.0 GO:0030070 insulin processing(GO:0030070)
0.0 0.0 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.0 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)