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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXA1
Z-value: 0.98
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Transcription factors associated with HOXA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA1 | hg19_v2_chr7_-_27135591_27135658 | -0.08 | 8.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.2 | 0.5 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.1 | 0.4 | GO:0032304 | negative regulation of icosanoid secretion(GO:0032304) |
| 0.1 | 0.4 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.1 | 0.4 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.0 | 0.3 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.0 | 0.3 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.0 | 0.3 | GO:1902414 | protein localization to cell junction(GO:1902414) |
| 0.0 | 0.3 | GO:0090520 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.1 | 0.2 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.3 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.2 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.0 | 0.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.1 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.0 | 0.1 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.0 | 0.1 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.0 | 0.1 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.0 | 0.0 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) leukotriene receptor activity(GO:0004974) |
| 0.1 | 0.3 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.0 | 0.3 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.0 | 0.3 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.3 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 0.3 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.0 | 0.3 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 0.2 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.0 | 0.2 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.0 | 0.2 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.5 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.4 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.0 | 0.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.1 | REACTOME DEFENSINS | Genes involved in Defensins |