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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOMEZ
Z-value: 0.91
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Transcription factors associated with HOMEZ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOMEZ | hg19_v2_chr14_-_23762777_23762821 | 0.25 | 6.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_116595028 Show fit | 0.99 |
ENST00000397751.1
|
ST7 overlapping transcript 4 |
|
| chr19_+_44617511 Show fit | 0.63 |
ENST00000262894.6
ENST00000588926.1 ENST00000592780.1 |
zinc finger protein 225 |
|
| chr17_+_73539232 Show fit | 0.56 |
ENST00000580925.1
|
lethal giant larvae homolog 2 (Drosophila) |
|
| chr8_-_65730127 Show fit | 0.55 |
ENST00000522106.1
|
RP11-1D12.2 |
|
| chr19_-_52643157 Show fit | 0.54 |
ENST00000597013.1
ENST00000600228.1 ENST00000596290.1 |
zinc finger protein 616 |
|
| chr17_-_61045902 Show fit | 0.52 |
ENST00000581596.1
|
RP11-180P8.3 |
|
| chr12_+_11187087 Show fit | 0.47 |
ENST00000601123.1
|
Uncharacterized protein |
|
| chr14_+_39944025 Show fit | 0.44 |
ENST00000554328.1
ENST00000556620.1 ENST00000557197.1 |
RP11-111A21.1 |
|
| chr3_-_196242233 Show fit | 0.43 |
ENST00000397537.2
|
single-pass membrane protein with coiled-coil domains 1 |
|
| chr6_+_116601330 Show fit | 0.41 |
ENST00000449314.1
ENST00000453463.1 |
RP1-93H18.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOMEZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.1 | 0.5 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.1 | 0.5 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.1 | 0.3 | GO:0071030 | nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048) |
| 0.1 | 0.3 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.0 | 0.3 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.0 | 0.3 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 0.3 | GO:0015801 | aromatic amino acid transport(GO:0015801) |
| 0.0 | 0.3 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.0 | 0.3 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 0.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.4 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 0.3 | GO:0071020 | post-spliceosomal complex(GO:0071020) |
| 0.0 | 0.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.3 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 0.2 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.0 | 0.2 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.0 | 0.2 | GO:0070847 | core mediator complex(GO:0070847) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.1 | 0.7 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.5 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.1 | 0.4 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.0 | 0.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.3 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.1 | 0.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 0.3 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.0 | 0.3 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.0 | 0.3 | GO:0030274 | LIM domain binding(GO:0030274) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |