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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HNF1A_HNF1B

Z-value: 0.78

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1 homeobox A
HNF1B
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416437_1214164790.928.6e-03Click!
HNF1Bhg19_v2_chr17_-_36105009_361050600.374.7e-01Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_36304201 1.43 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr5_+_176514413 1.30 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr11_-_111649074 1.13 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr17_+_4692230 0.66 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr7_-_27219849 0.59 ENST00000396344.4
HOXA10
homeobox A10
chr7_-_27219632 0.49 ENST00000470747.4
RP1-170O19.20
Uncharacterized protein
chr16_+_81272287 0.48 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chrX_-_15683147 0.48 ENST00000380342.3
TMEM27
transmembrane protein 27
chr10_+_99344104 0.44 ENST00000555577.1
ENST00000370649.3
PI4K2A
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein
chr2_-_47572105 0.41 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr1_+_17906970 0.39 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr4_-_110723134 0.39 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr1_-_168464875 0.37 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr4_-_110723194 0.36 ENST00000394635.3
CFI
complement factor I
chr11_-_111649015 0.36 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr3_-_137834436 0.35 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr6_+_144665237 0.33 ENST00000421035.2
UTRN
utrophin
chr19_+_6464502 0.33 ENST00000308243.7
CRB3
crumbs homolog 3 (Drosophila)
chr7_-_50633078 0.33 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr2_-_99917639 0.30 ENST00000308528.4
LYG1
lysozyme G-like 1
chr7_-_155601766 0.29 ENST00000430104.1
SHH
sonic hedgehog
chr3_+_187930429 0.29 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_+_27719697 0.28 ENST00000264717.2
ENST00000424318.2
GCKR
glucokinase (hexokinase 4) regulator
chr5_+_176513895 0.28 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
FGFR4
fibroblast growth factor receptor 4
chr3_-_161089289 0.28 ENST00000497137.1
SPTSSB
serine palmitoyltransferase, small subunit B
chr5_+_175976324 0.25 ENST00000261944.5
CDHR2
cadherin-related family member 2
chr17_+_79953310 0.24 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr17_+_73642486 0.22 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr19_+_6464243 0.22 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chr5_+_176513868 0.21 ENST00000292408.4
FGFR4
fibroblast growth factor receptor 4
chr9_+_140125385 0.21 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr22_-_32767017 0.21 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr8_-_124749609 0.21 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr6_+_31707725 0.21 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr11_+_64323156 0.21 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr16_-_57831914 0.20 ENST00000421376.2
KIFC3
kinesin family member C3
chr2_+_133174147 0.20 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr10_+_101542462 0.20 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr20_+_42187682 0.20 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr4_-_69817481 0.20 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_207262578 0.19 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr19_+_11350278 0.19 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chrX_+_107288239 0.19 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr9_+_130860810 0.18 ENST00000433501.1
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr9_+_130860583 0.18 ENST00000373064.5
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr20_+_35973080 0.18 ENST00000445403.1
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr16_+_89696692 0.18 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chrX_+_107288197 0.18 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr10_+_99344071 0.18 ENST00000370647.4
ENST00000370646.4
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr3_-_157221128 0.18 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr1_+_18807424 0.18 ENST00000400664.1
KLHDC7A
kelch domain containing 7A
chr9_-_215744 0.17 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr12_-_15865844 0.17 ENST00000543612.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr6_+_54173227 0.17 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr10_+_115312825 0.17 ENST00000537906.1
ENST00000541666.1
HABP2
hyaluronan binding protein 2
chr12_+_100867486 0.16 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr14_-_54425475 0.16 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr19_-_49565254 0.16 ENST00000593537.1
NTF4
neurotrophin 4
chr11_-_26743546 0.15 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr4_-_110723335 0.15 ENST00000394634.2
CFI
complement factor I
chr19_-_11639910 0.15 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr6_-_161085291 0.15 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr1_+_207262881 0.14 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chrX_+_48660107 0.14 ENST00000376643.2
HDAC6
histone deacetylase 6
chr15_+_58724184 0.14 ENST00000433326.2
LIPC
lipase, hepatic
chr1_-_36020531 0.14 ENST00000440579.1
ENST00000494948.1
KIAA0319L
KIAA0319-like
chr14_+_65171099 0.14 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr7_+_141695671 0.14 ENST00000497673.1
ENST00000475668.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr18_-_2982869 0.14 ENST00000584915.1
LPIN2
lipin 2
chr16_+_21244986 0.14 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr14_+_24590560 0.13 ENST00000558325.1
RP11-468E2.6
RP11-468E2.6
chr4_+_169013666 0.13 ENST00000359299.3
ANXA10
annexin A10
chr20_+_42187608 0.13 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr6_-_127840336 0.13 ENST00000525778.1
SOGA3
SOGA family member 3
chr6_-_127840021 0.13 ENST00000465909.2
SOGA3
SOGA family member 3
chr11_+_560956 0.13 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr4_+_8201091 0.13 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr22_-_32766972 0.12 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr6_-_33754778 0.12 ENST00000508327.1
ENST00000513701.1
LEMD2
LEM domain containing 2
chr22_+_45098067 0.12 ENST00000336985.6
ENST00000403696.1
ENST00000457960.1
ENST00000361473.5
PRR5
PRR5-ARHGAP8
proline rich 5 (renal)
PRR5-ARHGAP8 readthrough
chr5_-_10761206 0.12 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr12_+_100867694 0.12 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_+_54172653 0.12 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr9_-_13165457 0.12 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr16_-_57832004 0.11 ENST00000562503.1
KIFC3
kinesin family member C3
chr3_-_157221380 0.11 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr3_-_126327398 0.11 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr12_+_40787194 0.11 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr16_+_22524379 0.11 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr19_+_54466179 0.11 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr5_-_139726181 0.11 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr12_+_122242597 0.11 ENST00000267197.5
SETD1B
SET domain containing 1B
chr1_+_36789335 0.10 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr22_+_31003190 0.10 ENST00000407817.3
TCN2
transcobalamin II
chr8_+_21911054 0.10 ENST00000519850.1
ENST00000381470.3
DMTN
dematin actin binding protein
chr2_+_28718921 0.10 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1
phospholipase B1
chr16_-_57831676 0.10 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3
kinesin family member C3
chr5_+_6714718 0.10 ENST00000230859.6
ENST00000515721.1
PAPD7
PAP associated domain containing 7
chr22_-_22337204 0.10 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr2_+_109223595 0.10 ENST00000410093.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_175199674 0.10 ENST00000394967.2
SP9
Sp9 transcription factor
chr22_-_30970560 0.10 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr4_+_124571409 0.10 ENST00000514823.1
ENST00000511919.1
ENST00000508111.1
RP11-93L9.1
long intergenic non-protein coding RNA 1091
chr19_-_43099070 0.09 ENST00000244336.5
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr22_+_31003133 0.09 ENST00000405742.3
TCN2
transcobalamin II
chr17_-_26733179 0.09 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr3_-_157221357 0.09 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr15_+_67418047 0.09 ENST00000540846.2
SMAD3
SMAD family member 3
chr1_-_204183071 0.09 ENST00000308302.3
GOLT1A
golgi transport 1A
chr19_-_11639931 0.09 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr22_-_22337154 0.09 ENST00000413067.2
ENST00000437929.1
ENST00000456075.1
ENST00000434517.1
ENST00000424393.1
ENST00000449704.1
ENST00000437103.1
TOP3B
topoisomerase (DNA) III beta
chr6_+_144904334 0.09 ENST00000367526.4
UTRN
utrophin
chr7_-_87856303 0.09 ENST00000394641.3
SRI
sorcin
chr12_-_56615485 0.08 ENST00000549038.1
ENST00000552244.1
RNF41
ring finger protein 41
chr12_-_56615693 0.08 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
RNF41
ring finger protein 41
chr11_-_117170403 0.08 ENST00000504995.1
BACE1
beta-site APP-cleaving enzyme 1
chr18_+_61445205 0.08 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_-_116833500 0.08 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr9_-_116861337 0.08 ENST00000374118.3
KIF12
kinesin family member 12
chr9_+_140125209 0.08 ENST00000538474.1
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr12_+_60058458 0.08 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr10_+_5135981 0.08 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr14_+_65171315 0.08 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_+_120181457 0.08 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chr7_-_87856280 0.07 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr12_+_25205568 0.07 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr3_-_137893721 0.07 ENST00000505015.2
ENST00000260803.4
DBR1
debranching RNA lariats 1
chr1_+_84767289 0.07 ENST00000394834.3
ENST00000370669.1
SAMD13
sterile alpha motif domain containing 13
chr5_-_77844974 0.07 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr10_-_101690650 0.07 ENST00000543621.1
DNMBP
dynamin binding protein
chr5_+_73109339 0.07 ENST00000296799.4
ARHGEF28
Rho guanine nucleotide exchange factor (GEF) 28
chr22_+_31002779 0.07 ENST00000215838.3
TCN2
transcobalamin II
chr16_-_20587599 0.07 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr6_+_7541845 0.07 ENST00000418664.2
DSP
desmoplakin
chr6_-_127840453 0.07 ENST00000556132.1
SOGA3
SOGA family member 3
chr4_-_987164 0.07 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chrX_+_1710484 0.07 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr20_+_42984330 0.07 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_43029911 0.07 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr6_-_51952367 0.07 ENST00000340994.4
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr19_+_39138320 0.06 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
ACTN4
actinin, alpha 4
chr9_-_98079965 0.06 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr4_-_102267953 0.06 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr12_+_25205666 0.06 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_+_80838126 0.06 ENST00000266688.5
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr4_-_74486347 0.06 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_110284384 0.06 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr17_+_44803922 0.06 ENST00000465370.1
NSF
N-ethylmaleimide-sensitive factor
chr19_+_41305085 0.06 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr11_-_128894053 0.06 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr7_-_150020578 0.05 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr19_+_49467232 0.05 ENST00000599784.1
ENST00000594305.1
CTD-2639E6.9
CTD-2639E6.9
chr1_+_205197304 0.05 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr17_-_49021974 0.05 ENST00000501718.2
RP11-700H6.1
RP11-700H6.1
chr7_-_150020814 0.05 ENST00000477871.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr10_-_52645416 0.05 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr6_+_126221034 0.05 ENST00000433571.1
NCOA7
nuclear receptor coactivator 7
chr8_+_20054878 0.05 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr9_-_94712434 0.05 ENST00000375708.3
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr6_+_106534192 0.05 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr16_-_75284758 0.05 ENST00000561970.1
BCAR1
breast cancer anti-estrogen resistance 1
chr8_-_95220775 0.05 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_-_197036364 0.04 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr2_+_88047606 0.04 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr6_-_127840048 0.04 ENST00000467753.1
SOGA3
SOGA family member 3
chr3_+_187930491 0.04 ENST00000443217.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_-_138718973 0.04 ENST00000353963.3
ENST00000348729.3
SLC23A1
solute carrier family 23 (ascorbic acid transporter), member 1
chr4_-_1166954 0.04 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
SPON2
spondin 2, extracellular matrix protein
chr17_-_36904437 0.04 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
PCGF2
polycomb group ring finger 2
chr19_-_38916839 0.04 ENST00000433821.2
ENST00000426920.2
ENST00000587753.1
ENST00000454404.2
ENST00000293062.9
RASGRP4
RAS guanyl releasing protein 4
chr20_+_57414743 0.04 ENST00000313949.7
GNAS
GNAS complex locus
chr7_-_47579188 0.04 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr17_+_41052808 0.04 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr4_-_22444733 0.04 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr12_+_100750846 0.04 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr4_+_71494461 0.04 ENST00000396073.3
ENAM
enamelin
chr15_+_58430567 0.04 ENST00000536493.1
AQP9
aquaporin 9
chr19_+_39138271 0.04 ENST00000252699.2
ACTN4
actinin, alpha 4
chr3_+_183948161 0.04 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr10_-_52645379 0.04 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr20_+_57414795 0.04 ENST00000371098.2
ENST00000371075.3
GNAS
GNAS complex locus
chr3_+_72200408 0.04 ENST00000473713.1
LINC00870
long intergenic non-protein coding RNA 870
chrX_+_36254051 0.03 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr8_+_104892639 0.03 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr6_+_167704798 0.03 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr11_-_107729887 0.03 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr6_-_25874440 0.03 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr22_+_31002990 0.03 ENST00000423350.1
TCN2
transcobalamin II
chr7_-_47578840 0.03 ENST00000450444.1
TNS3
tensin 3
chr1_+_55505184 0.03 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr5_+_40841276 0.03 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr11_-_117695449 0.03 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr11_+_2405833 0.03 ENST00000527343.1
ENST00000464784.2
CD81
CD81 molecule
chr20_-_7921090 0.03 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_46740730 0.03 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr1_+_207262627 0.03 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr17_+_35732916 0.03 ENST00000586700.1
C17orf78
chromosome 17 open reading frame 78
chr15_-_42343388 0.03 ENST00000399518.3
PLA2G4E
phospholipase A2, group IVE
chr1_+_229406847 0.03 ENST00000366690.4
RAB4A
RAB4A, member RAS oncogene family
chr1_-_153585539 0.03 ENST00000368706.4
S100A16
S100 calcium binding protein A16

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:1903412 response to bile acid(GO:1903412)
0.2 1.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.4 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.1 0.4 GO:0016999 antibiotic metabolic process(GO:0016999)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) isoquinoline alkaloid metabolic process(GO:0033076)
0.1 0.3 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1 0.2 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 0.3 GO:0090675 intermicrovillar adhesion(GO:0090675)
0.1 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.3 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.2 GO:0090293 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.1 0.2 GO:0008052 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.0 0.3 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0070843 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.3 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.1 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.1 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.0 0.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.2 GO:0061150 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:2000224 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.0 0.3 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.0 0.2 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.4 GO:0015866 ADP transport(GO:0015866)
0.0 0.4 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.3 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.2 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.0 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.0 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.0 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.6 GO:0060065 uterus development(GO:0060065)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.0 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.0 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.0 0.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0051958 methotrexate transport(GO:0051958)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 0.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.2 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.0 GO:0097450 basilar dendrite(GO:0097441) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 1.0 GO:0031526 brush border membrane(GO:0031526)
0.0 0.0 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.0 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 1.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.4 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 0.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.2 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.0 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.0 1.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.0 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0015350 methotrexate transporter activity(GO:0015350)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D