ISMARA results: HMGA1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA1

Z-value: 1.55

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Transcription factors associated with HMGA1

Gene Symbol	Gene ID	Gene Info
HMGA1 Ensembl NCBI GeneCards UniProt	ENSG00000137309.15	high mobility group AT-hook 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HMGA1	hg19_v2_chr6_+_34204642_34204664	-0.73	1.0e-01	Click!

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_35013217 Show fit	2.38	ENST00000446375.1	DPY19L1 Ensembl NCBI GeneCards UniProt Show fit	dpy-19-like 1 (C. elegans)
chr8_-_90993869 Show fit	1.90	ENST00000517772.1	NBN Ensembl NCBI GeneCards UniProt Show fit	nibrin
chr12_+_20963647 Show fit	1.69	ENST00000381545.3	SLCO1B3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier organic anion transporter family, member 1B3
chr3_-_148939598 Show fit	1.59	ENST00000455472.3	CP Ensembl NCBI GeneCards UniProt Show fit	ceruloplasmin (ferroxidase)
chr7_-_81635106 Show fit	1.57	ENST00000443883.1	CACNA2D1 Ensembl NCBI GeneCards UniProt Show fit	calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr14_+_61449197 Show fit	1.52	ENST00000533744.2	SLC38A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 38, member 6
chr12_-_100656134 Show fit	1.44	ENST00000548313.1	DEPDC4 Ensembl NCBI GeneCards UniProt Show fit	DEP domain containing 4
chr1_+_196621002 Show fit	1.36	ENST00000367429.4 ENST00000439155.2	CFH Ensembl NCBI GeneCards UniProt Show fit	complement factor H
chr3_+_164924716 Show fit	1.32	ENST00000470138.1 ENST00000498616.1	RP11-85M11.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-85M11.2
chr1_+_95616933 Show fit	1.29	ENST00000604203.1	RP11-57H12.6 Ensembl NCBI GeneCards UniProt Show fit	TMEM56-RWDD3 readthrough

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.1	2.6	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.2	2.4	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1	2.3	GO:0006825	copper ion transport(GO:0006825)
0.3	1.9	GO:0031860	telomeric 3' overhang formation(GO:0031860)
0.1	1.7	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	1.7	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.2	1.6	GO:0086048	membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0	1.6	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.1	1.4	GO:0002084	protein depalmitoylation(GO:0002084)

Showing 1 to 10 of 161 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0072562	blood microparticle(GO:0072562)
0.1	2.1	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.9	GO:0030870	Mre11 complex(GO:0030870)
0.0	1.9	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	1.7	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	1.4	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	1.2	GO:0031429	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2	1.1	GO:0031673	H zone(GO:0031673)
0.0	1.1	GO:0043596	nuclear replication fork(GO:0043596)
0.0	1.0	GO:0032839	dendrite cytoplasm(GO:0032839)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.1	2.8	GO:0000030	mannosyltransferase activity(GO:0000030)
0.1	2.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.3	2.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.5	1.6	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.0	1.6	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
0.1	1.4	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	1.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.3	1.2	GO:0005018	platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.1	1.2	GO:0034513	box H/ACA snoRNA binding(GO:0034513)

Showing 1 to 10 of 99 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.4	PID FANCONI PATHWAY	Fanconi anemia pathway
2.3	PID INSULIN PATHWAY	Insulin Pathway
2.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.9	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.8	PID NOTCH PATHWAY	Notch signaling pathway
1.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.9	PID TCPTP PATHWAY	Signaling events mediated by TCPTP

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.6	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	2.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	2.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	2.1	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	1.9	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	1.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	1.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.1	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	1.1	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation

Showing 1 to 10 of 33 entries

Results for HMGA1

Z-value: 1.55

Motif logo

Transcription factors associated with HMGA1

Activity-expression correlation:

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: