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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HIF1A
Z-value: 1.82
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Transcription factors associated with HIF1A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIF1A | hg19_v2_chr14_+_62164340_62164443 | 0.84 | 3.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIF1A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.1 | GO:2000176 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 3.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.5 | 2.5 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569) |
| 0.1 | 2.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.5 | 2.0 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.2 | 2.0 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.3 | 1.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.2 | 1.7 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 1.7 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.0 | 1.7 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 2.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 2.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.7 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 1.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 1.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 1.6 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.5 | 1.5 | GO:0005960 | glycine cleavage complex(GO:0005960) |
| 0.1 | 1.5 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 2.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.5 | 2.5 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
| 0.5 | 2.0 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 0.2 | 1.7 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 1.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 1.6 | GO:0005292 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.0 | 1.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.4 | 1.5 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.0 | 1.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.2 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.2 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |