Project
A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for HIC2
Z-value: 2.03
Motif logo
Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg19_v2_chr22_+_21771656_21771693 | 0.57 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_55895966 Show fit | 1.65 |
ENST00000444469.3
|
transmembrane protein 238 |
|
| chr17_+_68047418 Show fit | 1.42 |
ENST00000586373.1
ENST00000588782.1 |
long intergenic non-protein coding RNA 1028 |
|
| chr16_+_70207686 Show fit | 1.32 |
ENST00000541793.2
ENST00000314151.8 ENST00000565806.1 ENST00000569347.2 ENST00000536907.2 |
C-type lectin domain family 18, member C |
|
| chr9_+_116225999 Show fit | 1.22 |
ENST00000317613.6
|
regulator of G-protein signaling 3 |
|
| chr17_-_42994283 Show fit | 1.19 |
ENST00000593179.1
|
glial fibrillary acidic protein |
|
| chr19_+_13988061 Show fit | 1.16 |
ENST00000339133.5
ENST00000397555.2 |
nanos homolog 3 (Drosophila) |
|
| chr11_+_64808675 Show fit | 1.07 |
ENST00000529996.1
|
SAC3 domain containing 1 |
|
| chr16_-_2581409 Show fit | 1.04 |
ENST00000567119.1
ENST00000565480.1 ENST00000382350.1 |
cementum protein 1 |
|
| chr9_-_130477912 Show fit | 0.93 |
ENST00000543175.1
|
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) |
|
| chr19_-_13261090 Show fit | 0.93 |
ENST00000588848.1
|
syntaxin 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 2.7 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 1.9 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.0 | 1.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 1.7 | GO:0015886 | heme transport(GO:0015886) |
| 0.2 | 1.6 | GO:0019075 | virus maturation(GO:0019075) |
| 0.1 | 1.6 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.1 | 1.5 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 1.5 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.1 | 1.4 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 2.0 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.1 | 1.9 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.9 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 1.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 1.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.4 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 1.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 1.3 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 4.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 2.6 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 2.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.8 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.1 | 1.7 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.2 | 1.5 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.1 | 1.5 | GO:0070513 | death domain binding(GO:0070513) |
| 0.1 | 1.5 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 2.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.0 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 1.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.3 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |