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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HIC1
Z-value: 1.58
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Transcription factors associated with HIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC1 | hg19_v2_chr17_+_1959369_1959604 | 0.53 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_74212073 Show fit | 1.81 |
ENST00000441217.1
|
AC073046.25 |
|
| chr16_+_84002234 Show fit | 1.64 |
ENST00000305202.4
|
N-terminal EF-hand calcium binding protein 2 |
|
| chr14_-_94254821 Show fit | 0.86 |
ENST00000393140.1
|
proline rich membrane anchor 1 |
|
| chr5_+_23951673 Show fit | 0.80 |
ENST00000507936.1
|
chromosome 5 open reading frame 17 |
|
| chr9_-_130742792 Show fit | 0.70 |
ENST00000373095.1
|
family with sequence similarity 102, member A |
|
| chr11_+_777562 Show fit | 0.63 |
ENST00000530083.1
|
Protein LOC100506518 |
|
| chr3_-_137834436 Show fit | 0.62 |
ENST00000327532.2
ENST00000467030.1 |
DAZ interacting zinc finger protein 1-like |
|
| chr16_+_765092 Show fit | 0.61 |
ENST00000568223.2
|
meteorin, glial cell differentiation regulator |
|
| chr19_-_18717627 Show fit | 0.61 |
ENST00000392386.3
|
cytokine receptor-like factor 1 |
|
| chr16_+_1662326 Show fit | 0.59 |
ENST00000397412.3
|
Crm, cramped-like (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.9 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.0 | 1.5 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 1.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 1.3 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 1.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.3 | 1.0 | GO:1903697 | negative regulation of microvillus assembly(GO:1903697) |
| 0.1 | 0.9 | GO:2001151 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 0.0 | 0.9 | GO:0042135 | neurotransmitter catabolic process(GO:0042135) |
| 0.3 | 0.8 | GO:0060929 | Purkinje myocyte differentiation(GO:0003168) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929) |
| 0.1 | 0.7 | GO:0006477 | protein sulfation(GO:0006477) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.9 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 0.8 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 0.7 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.1 | 0.7 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 0.7 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.7 | GO:0031528 | microvillus membrane(GO:0031528) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.0 | 1.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 0.9 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.1 | 0.9 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 0.8 | GO:0010736 | serum response element binding(GO:0010736) |
| 0.1 | 0.8 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 1.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 1.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.8 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 0.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.8 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |