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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GZF1

Z-value: 0.76

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Transcription factors associated with GZF1

Gene Symbol Gene ID Gene Info
GZF1
ENSG00000125812.11 GDNF inducible zinc finger protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GZF1hg19_v2_chr20_+_23342783_23342957-0.167.6e-01Click!

Activity profile of GZF1 motif

Sorted Z-values of GZF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_79115503 1.30 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr12_-_107168696 0.62 ENST00000551505.1
RP11-144F15.1
Uncharacterized protein
chr12_-_76478386 0.45 ENST00000535020.2
NAP1L1
nucleosome assembly protein 1-like 1
chr3_-_114035026 0.45 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr4_-_147443043 0.43 ENST00000394059.4
ENST00000502607.1
ENST00000335472.7
ENST00000432059.2
ENST00000394062.3
SLC10A7
solute carrier family 10, member 7
chr3_-_170588163 0.38 ENST00000295830.8
RPL22L1
ribosomal protein L22-like 1
chr4_-_89619386 0.37 ENST00000323061.5
NAP1L5
nucleosome assembly protein 1-like 5
chr12_+_102513950 0.37 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr14_-_92413727 0.34 ENST00000267620.10
FBLN5
fibulin 5
chr10_+_89264625 0.34 ENST00000371996.4
ENST00000371994.4
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr2_-_74776586 0.33 ENST00000420535.1
LOXL3
lysyl oxidase-like 3
chr2_-_150444300 0.32 ENST00000303319.5
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr4_-_147442817 0.32 ENST00000507030.1
SLC10A7
solute carrier family 10, member 7
chr19_-_44384291 0.31 ENST00000324394.6
ZNF404
zinc finger protein 404
chr12_-_76478417 0.30 ENST00000552342.1
NAP1L1
nucleosome assembly protein 1-like 1
chr10_-_126849626 0.30 ENST00000530884.1
CTBP2
C-terminal binding protein 2
chr16_-_30582888 0.30 ENST00000563707.1
ENST00000567855.1
ZNF688
zinc finger protein 688
chr3_-_87039662 0.29 ENST00000494229.1
VGLL3
vestigial like 3 (Drosophila)
chr14_-_92413353 0.28 ENST00000556154.1
FBLN5
fibulin 5
chr12_-_76478446 0.27 ENST00000393263.3
ENST00000548044.1
ENST00000547704.1
ENST00000431879.3
ENST00000549596.1
ENST00000550934.1
ENST00000551600.1
ENST00000547479.1
ENST00000547773.1
ENST00000544816.1
ENST00000542344.1
ENST00000548273.1
NAP1L1
nucleosome assembly protein 1-like 1
chr12_+_104458235 0.26 ENST00000229330.4
HCFC2
host cell factor C2
chr2_-_150444116 0.26 ENST00000428879.1
ENST00000422782.2
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr1_-_11107280 0.25 ENST00000400897.3
ENST00000400898.3
MASP2
mannan-binding lectin serine peptidase 2
chr19_+_36157715 0.20 ENST00000379013.2
ENST00000222275.2
UPK1A
uroplakin 1A
chr12_-_102513843 0.20 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr13_+_98086445 0.19 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr9_-_124976185 0.19 ENST00000464484.2
LHX6
LIM homeobox 6
chr5_+_170814803 0.16 ENST00000521672.1
ENST00000351986.6
ENST00000393820.2
ENST00000523622.1
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr7_-_105029329 0.16 ENST00000393651.3
ENST00000460391.1
SRPK2
SRSF protein kinase 2
chr7_-_27183263 0.15 ENST00000222726.3
HOXA5
homeobox A5
chr10_+_97759848 0.15 ENST00000424464.1
ENST00000410012.2
ENST00000344386.3
CC2D2B
coiled-coil and C2 domain containing 2B
chr14_-_52535712 0.13 ENST00000216286.5
ENST00000541773.1
NID2
nidogen 2 (osteonidogen)
chr3_+_30647994 0.13 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr16_-_46797149 0.12 ENST00000536476.1
MYLK3
myosin light chain kinase 3
chr4_+_26344754 0.12 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr10_+_60028818 0.12 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr3_+_30648066 0.10 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr6_+_30525051 0.09 ENST00000376557.3
PRR3
proline rich 3
chr16_+_86612112 0.09 ENST00000320241.3
FOXL1
forkhead box L1
chr11_-_17498348 0.09 ENST00000389817.3
ENST00000302539.4
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr10_+_14880364 0.09 ENST00000441647.1
HSPA14
heat shock 70kDa protein 14
chr14_-_53619816 0.08 ENST00000323669.5
ENST00000395606.1
ENST00000357758.3
DDHD1
DDHD domain containing 1
chr7_-_26904317 0.08 ENST00000345317.2
SKAP2
src kinase associated phosphoprotein 2
chr6_+_30524663 0.08 ENST00000376560.3
PRR3
proline rich 3
chr1_+_26606608 0.08 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr3_-_87040233 0.08 ENST00000398399.2
VGLL3
vestigial like 3 (Drosophila)
chr9_-_124976154 0.07 ENST00000482062.1
LHX6
LIM homeobox 6
chrX_+_54835493 0.05 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr5_-_176827631 0.05 ENST00000358571.2
PFN3
profilin 3
chrX_+_48367338 0.05 ENST00000359882.4
ENST00000537758.1
ENST00000367574.4
ENST00000355961.4
ENST00000489940.1
ENST00000361988.3
PORCN
porcupine homolog (Drosophila)
chr16_+_87636474 0.04 ENST00000284262.2
JPH3
junctophilin 3
chr1_-_144995074 0.03 ENST00000534536.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_107168418 0.03 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8B
RIC8 guanine nucleotide exchange factor B
chr6_-_30524951 0.03 ENST00000376621.3
GNL1
guanine nucleotide binding protein-like 1
chr19_+_38880695 0.03 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chr11_+_64937625 0.03 ENST00000377185.2
SPDYC
speedy/RINGO cell cycle regulator family member C
chr3_-_79816965 0.02 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr11_+_101918153 0.02 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70
chr1_-_226374373 0.02 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr10_-_14880566 0.02 ENST00000378442.1
CDNF
cerebral dopamine neurotrophic factor
chr1_+_41174988 0.01 ENST00000372652.1
NFYC
nuclear transcription factor Y, gamma
chr4_-_147442982 0.01 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr20_-_31331212 0.01 ENST00000474815.2
ENST00000446419.2
COMMD7
COMM domain containing 7
chr10_-_126849588 0.00 ENST00000411419.2
CTBP2
C-terminal binding protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057) negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.0 0.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0048769 sarcomerogenesis(GO:0048769)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.0 0.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.2 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
0.0 0.1 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008969 phosphohistidine phosphatase activity(GO:0008969)
0.1 0.2 GO:0001855 complement component C4b binding(GO:0001855)
0.1 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.0 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators