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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GTF2I
Z-value: 1.32
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Transcription factors associated with GTF2I
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2I | hg19_v2_chr7_+_74072288_74072357 | -0.49 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_50094866 Show fit | 1.40 |
ENST00000418929.2
|
proline rich 12 |
|
| chr14_-_61191049 Show fit | 0.96 |
ENST00000556952.3
|
SIX homeobox 4 |
|
| chr6_-_10412600 Show fit | 0.78 |
ENST00000379608.3
|
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
|
| chr2_+_128175997 Show fit | 0.78 |
ENST00000234071.3
ENST00000429925.1 ENST00000442644.1 ENST00000453608.2 |
protein C (inactivator of coagulation factors Va and VIIIa) |
|
| chr16_+_29819372 Show fit | 0.77 |
ENST00000568544.1
ENST00000569978.1 |
MYC-associated zinc finger protein (purine-binding transcription factor) |
|
| chr17_+_46131912 Show fit | 0.73 |
ENST00000584634.1
ENST00000580050.1 |
nuclear factor, erythroid 2-like 1 |
|
| chr19_-_31840438 Show fit | 0.69 |
ENST00000240587.4
|
teashirt zinc finger homeobox 3 |
|
| chr1_-_27930102 Show fit | 0.68 |
ENST00000247087.5
ENST00000374011.2 |
AT hook, DNA binding motif, containing 1 |
|
| chr2_+_219264466 Show fit | 0.68 |
ENST00000273062.2
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
|
| chr1_+_27022839 Show fit | 0.67 |
ENST00000457599.2
|
AT rich interactive domain 1A (SWI-like) |
Network of associatons between targets according to the STRING database.
First level regulatory network of GTF2I
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.3 | 1.6 | GO:0003404 | optic vesicle morphogenesis(GO:0003404) |
| 0.4 | 1.4 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 0.0 | 1.4 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.2 | 1.3 | GO:0003408 | optic cup formation involved in camera-type eye development(GO:0003408) |
| 0.2 | 1.2 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.0 | 1.2 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 1.0 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.2 | 0.9 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 0.9 | GO:0048625 | myoblast fate commitment(GO:0048625) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 1.3 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 1.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 0.9 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 0.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 0.9 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 0.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.8 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.8 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 2.1 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 2.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 1.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 1.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 1.2 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 1.2 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 1.0 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 0.9 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 0.9 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.1 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 1.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.2 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 1.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.9 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.7 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |