ISMARA results: GMEB2

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GMEB2

Z-value: 2.12

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Transcription factors associated with GMEB2

Gene Symbol	Gene ID	Gene Info
GMEB2 Ensembl NCBI GeneCards UniProt	ENSG00000101216.6	glucocorticoid modulatory element binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GMEB2	hg19_v2_chr20_-_62258394_62258464	-0.86	2.7e-02	Click!

Activity profile of GMEB2 motif

Sorted Z-values of GMEB2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_112451222 Show fit	3.39	ENST00000552052.1	ERP29 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum protein 29
chr16_-_3493528 Show fit	2.03	ENST00000301744.4	ZNF597 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 597
chr5_+_162887556 Show fit	1.92	ENST00000393915.4 ENST00000432118.2 ENST00000358715.3	HMMR Ensembl NCBI GeneCards UniProt Show fit	hyaluronan-mediated motility receptor (RHAMM)
chr7_-_19748640 Show fit	1.65	ENST00000222567.5	TWISTNB Ensembl NCBI GeneCards UniProt Show fit	TWIST neighbor
chr3_-_149688502 Show fit	1.57	ENST00000481767.1 ENST00000475518.1	PFN2 Ensembl NCBI GeneCards UniProt Show fit	profilin 2
chr2_+_196521845 Show fit	1.56	ENST00000359634.5 ENST00000412905.1	SLC39A10 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 (zinc transporter), member 10
chr2_+_28974489 Show fit	1.47	ENST00000455580.1	PPP1CB Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1, catalytic subunit, beta isozyme
chr7_-_108209897 Show fit	1.41	ENST00000313516.5	THAP5 Ensembl NCBI GeneCards UniProt Show fit	THAP domain containing 5
chr1_-_74663825 Show fit	1.37	ENST00000370911.3 ENST00000370909.2 ENST00000354431.4	LRRIQ3 Ensembl NCBI GeneCards UniProt Show fit	leucine-rich repeats and IQ motif containing 3
chr2_+_99758161 Show fit	1.35	ENST00000409684.1	C2ORF15 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein C2orf15

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GMEB2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0	3.7	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.7	3.6	GO:1903613	regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.7	3.4	GO:0043335	protein unfolding(GO:0043335)
0.2	3.2	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.3	3.0	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.2	3.0	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	2.5	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	2.5	GO:0002181	cytoplasmic translation(GO:0002181)
0.4	2.2	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)

Showing 1 to 10 of 252 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.4	4.5	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	3.5	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.5	3.2	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.2	3.2	GO:0042587	glycogen granule(GO:0042587)
0.0	2.7	GO:0043195	terminal bouton(GO:0043195)
0.0	2.7	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	2.2	GO:0000125	PCAF complex(GO:0000125)
0.0	2.2	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	2.1	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Showing 1 to 10 of 119 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	4.1	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1	4.0	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	3.7	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.2	3.6	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	3.6	GO:0003785	actin monomer binding(GO:0003785)
0.6	3.2	GO:0050115	myosin-light-chain-phosphatase activity(GO:0050115)
0.0	3.0	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.1	2.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.5	1.9	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)

Showing 1 to 10 of 191 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	PID PLK1 PATHWAY	PLK1 signaling events
0.1	3.0	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	2.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	2.2	PID MYC PATHWAY	C-MYC pathway
0.0	2.0	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	1.5	PID ARF6 PATHWAY	Arf6 signaling events
0.1	1.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.8	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	3.6	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	3.4	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	3.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	3.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	2.7	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	2.3	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	2.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	2.1	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1	2.0	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism

Showing 1 to 10 of 62 entries

Results for GMEB2

Z-value: 2.12

Motif logo

Transcription factors associated with GMEB2

Activity-expression correlation:

Activity profile of GMEB2 motif

Sorted Z-values of GMEB2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GMEB2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: