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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GLI2
Z-value: 1.13
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Transcription factors associated with GLI2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI2 | hg19_v2_chr2_+_121493717_121493823 | 0.47 | 3.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_48673465 Show fit | 0.90 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr3_+_184279566 Show fit | 0.60 |
ENST00000330394.2
|
EPH receptor B3 |
|
| chr19_-_49522727 Show fit | 0.56 |
ENST00000600007.1
|
CTB-60B18.10 |
|
| chr7_-_92465868 Show fit | 0.55 |
ENST00000424848.2
|
cyclin-dependent kinase 6 |
|
| chr12_+_116985896 Show fit | 0.52 |
ENST00000547114.1
|
RP11-809C9.2 |
|
| chr3_-_10052869 Show fit | 0.44 |
ENST00000454232.1
|
AC022007.5 |
|
| chr9_-_99329098 Show fit | 0.42 |
ENST00000452280.1
|
cell division cycle 14B |
|
| chr2_+_85646054 Show fit | 0.40 |
ENST00000389938.2
|
SH2 domain containing 6 |
|
| chr7_-_127032114 Show fit | 0.40 |
ENST00000436992.1
|
zinc finger protein 800 |
|
| chr17_-_80059726 Show fit | 0.39 |
ENST00000583053.1
|
coiled-coil domain containing 57 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:1903461 | Okazaki fragment processing involved in mitotic DNA replication(GO:1903461) |
| 0.0 | 0.8 | GO:0022038 | corpus callosum development(GO:0022038) |
| 0.0 | 0.6 | GO:0043697 | dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) |
| 0.0 | 0.6 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.0 | 0.6 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 0.5 | GO:0090598 | male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598) |
| 0.0 | 0.5 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.5 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.0 | 0.5 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.1 | 0.4 | GO:0051795 | positive regulation of catagen(GO:0051795) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.5 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.5 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 0.5 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 0.3 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 0.7 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.2 | 0.6 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.0 | 0.6 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 0.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 0.5 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 0.5 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 0.4 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.1 | 0.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 0.4 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.4 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.0 | 0.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.1 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |