ISMARA results: GATA3

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GATA3

Z-value: 2.22

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Transcription factors associated with GATA3

Gene Symbol	Gene ID	Gene Info
GATA3 Ensembl NCBI GeneCards UniProt	ENSG00000107485.11	GATA binding protein 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA3	hg19_v2_chr10_+_8096769_8096787	0.98	4.2e-04	Click!

Activity profile of GATA3 motif

Sorted Z-values of GATA3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_16008880 Show fit	1.51	ENST00000011989.7 ENST00000221700.6	CYP4F2 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450, family 4, subfamily F, polypeptide 2
chr21_-_46492927 Show fit	1.28	ENST00000599569.1	AP001579.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr12_-_13105081 Show fit	1.20	ENST00000541128.1	GPRC5D Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor, family C, group 5, member D
chr17_-_33448468 Show fit	1.17	ENST00000591723.1 ENST00000593039.1 ENST00000587405.1	RAD51L3-RFFL Ensembl NCBI GeneCards UniProt Show fit RAD51D Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein RAD51 paralog D
chr9_-_34662651 Show fit	1.04	ENST00000259631.4	CCL27 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-C motif) ligand 27
chr1_+_236557569 Show fit	0.96	ENST00000334232.4	EDARADD Ensembl NCBI GeneCards UniProt Show fit	EDAR-associated death domain
chr6_+_31515337 Show fit	0.95	ENST00000376148.4 ENST00000376145.4	NFKBIL1 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr3_+_127317945 Show fit	0.90	ENST00000472731.1	MCM2 Ensembl NCBI GeneCards UniProt Show fit	minichromosome maintenance complex component 2
chr17_+_33448593 Show fit	0.86	ENST00000158009.5	FNDC8 Ensembl NCBI GeneCards UniProt Show fit	fibronectin type III domain containing 8
chr13_+_111837279 Show fit	0.80	ENST00000467053.1	ARHGEF7 Ensembl NCBI GeneCards UniProt Show fit	Rho guanine nucleotide exchange factor (GEF) 7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0018146	keratan sulfate biosynthetic process(GO:0018146)
0.0	1.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	1.8	GO:0006007	glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.5	1.6	GO:0032304	negative regulation of icosanoid secretion(GO:0032304)
0.0	1.6	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.0	1.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	1.5	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	1.5	GO:0030574	collagen catabolic process(GO:0030574)
0.2	1.4	GO:0023021	termination of signal transduction(GO:0023021)
0.1	1.4	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)

Showing 1 to 10 of 966 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	2.1	GO:0002102	podosome(GO:0002102)
0.1	1.9	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.1	1.8	GO:0042555	MCM complex(GO:0042555)
0.0	1.8	GO:0045095	keratin filament(GO:0045095)
0.0	1.8	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	1.6	GO:0016363	nuclear matrix(GO:0016363)
0.1	1.5	GO:0071564	npBAF complex(GO:0071564)
0.0	1.4	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	1.4	GO:0005901	caveola(GO:0005901)

Showing 1 to 10 of 299 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	1.9	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	1.7	GO:0004984	olfactory receptor activity(GO:0004984)
0.0	1.7	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	1.6	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	1.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	1.4	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	1.4	GO:0042169	SH2 domain binding(GO:0042169)
0.4	1.3	GO:0052870	tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.2	1.3	GO:0031962	mineralocorticoid receptor binding(GO:0031962)

Showing 1 to 10 of 570 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	2.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	2.1	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.1	1.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.7	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.6	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	1.5	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.4	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.4	PID RHOA PATHWAY	RhoA signaling pathway

Showing 1 to 10 of 86 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	3.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	2.7	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0	2.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.3	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	2.1	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	2.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	1.7	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	1.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism

Showing 1 to 10 of 105 entries

Results for GATA3

Z-value: 2.22

Motif logo

Transcription factors associated with GATA3

Activity-expression correlation:

Activity profile of GATA3 motif

Sorted Z-values of GATA3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: