ISMARA results: FOXN1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXN1

Z-value: 1.28

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Transcription factors associated with FOXN1

Gene Symbol	Gene ID	Gene Info
FOXN1 Ensembl NCBI GeneCards UniProt	ENSG00000109101.3	forkhead box N1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXN1	hg19_v2_chr17_+_26833250_26833278	-0.02	9.7e-01	Click!

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_93954358 Show fit	1.50	ENST00000504099.1	ANKRD32 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat domain 32
chr15_+_71185148 Show fit	1.30	ENST00000443425.2 ENST00000560755.1	LRRC49 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 49
chr2_+_46769798 Show fit	1.14	ENST00000238738.4	RHOQ Ensembl NCBI GeneCards UniProt Show fit	ras homolog family member Q
chr15_+_71184931 Show fit	1.11	ENST00000560369.1 ENST00000260382.5	LRRC49 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 49
chr15_-_71184724 Show fit	1.10	ENST00000560604.1	THAP10 Ensembl NCBI GeneCards UniProt Show fit	THAP domain containing 10
chr15_-_55700216 Show fit	0.95	ENST00000569205.1	CCPG1 Ensembl NCBI GeneCards UniProt Show fit	cell cycle progression 1
chr13_-_88323218 Show fit	0.89	ENST00000436290.2 ENST00000453832.2 ENST00000606590.1	MIR4500HG Ensembl NCBI GeneCards UniProt Show fit	MIR4500 host gene (non-protein coding)
chr5_+_61602236 Show fit	0.84	ENST00000514082.1 ENST00000407818.3	KIF2A Ensembl NCBI GeneCards UniProt Show fit	kinesin heavy chain member 2A
chr2_-_28113217 Show fit	0.83	ENST00000444339.2	RBKS Ensembl NCBI GeneCards UniProt Show fit	ribokinase
chr1_+_74663994 Show fit	0.82	ENST00000472069.1	FPGT Ensembl NCBI GeneCards UniProt Show fit	fucose-1-phosphate guanylyltransferase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	GO:0090307	mitotic spindle assembly(GO:0090307)
0.3	2.0	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.3	1.6	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.0	1.6	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	1.5	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0	1.5	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.1	1.3	GO:0030916	otic vesicle formation(GO:0030916)
0.1	1.3	GO:0000338	protein deneddylation(GO:0000338)
0.0	1.2	GO:0006004	fucose metabolic process(GO:0006004)
0.2	1.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)

Showing 1 to 10 of 91 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0097228	sperm principal piece(GO:0097228)
0.0	1.8	GO:0030660	Golgi-associated vesicle membrane(GO:0030660)
0.3	1.6	GO:0098837	postsynaptic recycling endosome(GO:0098837)
0.1	1.5	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.1	1.3	GO:0036038	MKS complex(GO:0036038)
0.0	1.3	GO:0008180	COP9 signalosome(GO:0008180)
0.0	1.2	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	1.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.8	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.7	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0031489	myosin V binding(GO:0031489)
0.4	1.5	GO:0032427	GBD domain binding(GO:0032427)
0.0	1.4	GO:0030331	estrogen receptor binding(GO:0030331)
0.1	1.3	GO:0051011	microtubule minus-end binding(GO:0051011)
0.1	1.3	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.2	1.2	GO:0070568	guanylyltransferase activity(GO:0070568)
0.0	1.1	GO:0000175	3'-5'-exoribonuclease activity(GO:0000175)
0.0	1.1	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	1.1	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	1.0	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)

Showing 1 to 10 of 51 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.2	PID PLK1 PATHWAY	PLK1 signaling events
1.6	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
1.5	PID BARD1 PATHWAY	BARD1 signaling events
1.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.8	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.6	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	1.6	REACTOME KINESINS	Genes involved in Kinesins
0.0	1.5	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	1.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.1	1.1	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	1.1	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.7	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.6	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.5	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C

Showing 1 to 10 of 19 entries

Results for FOXN1

Z-value: 1.28

Motif logo

Transcription factors associated with FOXN1

Activity-expression correlation:

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: