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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOXL1
Z-value: 1.37
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Transcription factors associated with FOXL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXL1 | hg19_v2_chr16_+_86612112_86612123 | -0.63 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_95616933 Show fit | 2.40 |
ENST00000604203.1
|
TMEM56-RWDD3 readthrough |
|
| chr14_+_61449197 Show fit | 1.45 |
ENST00000533744.2
|
solute carrier family 38, member 6 |
|
| chr2_+_187371440 Show fit | 1.40 |
ENST00000445547.1
|
zinc finger CCCH-type containing 15 |
|
| chr12_+_20963647 Show fit | 1.20 |
ENST00000381545.3
|
solute carrier organic anion transporter family, member 1B3 |
|
| chr9_-_125240235 Show fit | 1.14 |
ENST00000259357.2
|
olfactory receptor, family 1, subfamily J, member 1 |
|
| chr12_+_20963632 Show fit | 0.94 |
ENST00000540853.1
ENST00000261196.2 |
solute carrier organic anion transporter family, member 1B3 |
|
| chr2_+_38177575 Show fit | 0.93 |
ENST00000407257.1
ENST00000417700.2 ENST00000234195.3 ENST00000442857.1 |
regulator of microtubule dynamics 2 |
|
| chr5_-_145483932 Show fit | 0.89 |
ENST00000311450.4
|
PLAC8-like 1 |
|
| chr3_-_148939598 Show fit | 0.75 |
ENST00000455472.3
|
ceruloplasmin (ferroxidase) |
|
| chr3_-_46068969 Show fit | 0.73 |
ENST00000542109.1
ENST00000395946.2 |
chemokine (C motif) receptor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 1.8 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 1.0 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.0 | 1.0 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.1 | 0.9 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.0 | 0.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.8 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.1 | 0.8 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.0 | 0.8 | GO:0006825 | copper ion transport(GO:0006825) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 0.8 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.1 | 0.7 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.7 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 0.6 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.6 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 1.7 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 1.2 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 1.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.8 | GO:0001637 | G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950) |
| 0.0 | 0.8 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 0.7 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.1 | 0.7 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.7 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 0.7 | GO:0089720 | caspase binding(GO:0089720) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 0.1 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.1 | PID EPO PATHWAY | EPO signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 1.2 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 0.5 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.5 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.5 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |