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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 1.27
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000164916.9 | forkhead box K1 | |
| ENSG00000128573.18 | forkhead box P2 | |
| ENSG00000171956.5 | forkhead box B1 | |
| ENSG00000049768.10 | forkhead box P3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXK1 | hg19_v2_chr7_+_4721885_4721945 | -0.27 | 6.0e-01 | Click! |
| FOXP3 | hg19_v2_chrX_-_49121165_49121288 | 0.08 | 8.8e-01 | Click! |
| FOXP2 | hg19_v2_chr7_+_114055052_114055378 | -0.06 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_152178320 Show fit | 2.16 |
ENST00000429352.1
|
RP11-107M16.2 |
|
| chr3_-_178865747 Show fit | 0.92 |
ENST00000435560.1
|
RP11-360P21.2 |
|
| chr7_-_84121858 Show fit | 0.77 |
ENST00000448879.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
|
| chrX_+_78003204 Show fit | 0.76 |
ENST00000435339.3
ENST00000514744.1 |
lysophosphatidic acid receptor 4 |
|
| chr6_-_32083106 Show fit | 0.71 |
ENST00000442721.1
|
tenascin XB |
|
| chr18_-_53303123 Show fit | 0.71 |
ENST00000569357.1
ENST00000565124.1 ENST00000398339.1 |
transcription factor 4 |
|
| chr8_+_101349823 Show fit | 0.68 |
ENST00000519566.1
|
KB-1991G8.1 |
|
| chr1_+_92545862 Show fit | 0.67 |
ENST00000370382.3
ENST00000342818.3 |
BTB (POZ) domain containing 8 |
|
| chr17_-_7082668 Show fit | 0.66 |
ENST00000573083.1
ENST00000574388.1 |
asialoglycoprotein receptor 1 |
|
| chr1_+_116654376 Show fit | 0.64 |
ENST00000369500.3
|
mab-21-like 3 (C. elegans) |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.3 | 1.2 | GO:0001079 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
| 0.2 | 0.8 | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) |
| 0.1 | 0.8 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.1 | 0.8 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 0.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 0.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 0.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.7 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.3 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.0 | 1.2 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 0.8 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 0.7 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.6 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.3 | 1.2 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.1 | 0.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 0.9 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.8 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 0.8 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.6 | GO:0004949 | cannabinoid receptor activity(GO:0004949) |
| 0.1 | 0.6 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.1 | 0.6 | GO:0005119 | smoothened binding(GO:0005119) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.8 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.5 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.5 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |