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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOSL1
Z-value: 1.17
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Transcription factors associated with FOSL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667997_65668044 | 0.97 | 1.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_130597935 Show fit | 1.45 |
ENST00000447307.1
ENST00000418546.1 |
microRNA 29a |
|
| chr17_-_39769005 Show fit | 0.97 |
ENST00000301653.4
ENST00000593067.1 |
keratin 16 |
|
| chr15_+_41062159 Show fit | 0.93 |
ENST00000344320.6
|
chromosome 15 open reading frame 62 |
|
| chr1_+_156084461 Show fit | 0.90 |
ENST00000347559.2
ENST00000361308.4 ENST00000368300.4 ENST00000368299.3 |
lamin A/C |
|
| chr1_-_12679171 Show fit | 0.84 |
ENST00000606790.1
|
RP11-474O21.5 |
|
| chr10_+_17270214 Show fit | 0.81 |
ENST00000544301.1
|
vimentin |
|
| chr16_+_83986827 Show fit | 0.78 |
ENST00000393306.1
ENST00000565123.1 |
oxidative stress induced growth inhibitor 1 |
|
| chr19_-_56056888 Show fit | 0.73 |
ENST00000592464.1
ENST00000420723.3 |
SH3 domain binding kinase family, member 3 |
|
| chr3_+_57094469 Show fit | 0.71 |
ENST00000334325.1
|
spermatogenesis associated 12 |
|
| chr1_+_156096336 Show fit | 0.70 |
ENST00000504687.1
ENST00000473598.2 |
lamin A/C |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.0 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.1 | 1.4 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 1.2 | GO:0034629 | cellular protein complex localization(GO:0034629) |
| 0.1 | 1.1 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.0 | 1.1 | GO:0043303 | mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303) |
| 0.1 | 1.0 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.0 | 1.0 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.8 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.1 | 0.8 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.0 | 0.8 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 2.0 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 1.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.1 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 1.1 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 1.0 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 1.0 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 0.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.8 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.3 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 1.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 1.0 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 1.0 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.0 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 0.8 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.1 | 0.7 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.0 | 0.7 | GO:0005165 | neurotrophin receptor binding(GO:0005165) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.9 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.9 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.7 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 2.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.3 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.9 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.8 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.6 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |