ISMARA results: FLI1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FLI1

Z-value: 1.51

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Transcription factors associated with FLI1

Gene Symbol	Gene ID	Gene Info
FLI1 Ensembl NCBI GeneCards UniProt	ENSG00000151702.12	Fli-1 proto-oncogene, ETS transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FLI1	hg19_v2_chr11_+_128562372_128562397	-0.74	8.9e-02	Click!

Activity profile of FLI1 motif

Sorted Z-values of FLI1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_27068704 Show fit	2.68	ENST00000444388.1 ENST00000450963.1 ENST00000449017.1	CTA-211A9.5 Ensembl NCBI GeneCards UniProt Show fit	CTA-211A9.5
chr2_+_74212073 Show fit	1.58	ENST00000441217.1	AC073046.25 Ensembl NCBI GeneCards UniProt Show fit	AC073046.25
chr12_+_48147699 Show fit	1.37	ENST00000548498.1	SLC48A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 48 (heme transporter), member 1
chr11_-_9482010 Show fit	1.12	ENST00000596206.1	AC132192.1 Ensembl NCBI GeneCards UniProt Show fit	LOC644656 protein; Uncharacterized protein
chr5_+_180650271 Show fit	0.91	ENST00000351937.5 ENST00000315073.5	TRIM41 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 41
chr11_-_46722117 Show fit	0.90	ENST00000311956.4	ARHGAP1 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 1
chr5_-_151066514 Show fit	0.89	ENST00000538026.1 ENST00000522348.1 ENST00000521569.1	SPARC Ensembl NCBI GeneCards UniProt Show fit	secreted protein, acidic, cysteine-rich (osteonectin)
chr5_-_138861926 Show fit	0.88	ENST00000510817.1	TMEM173 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 173
chr12_+_122018697 Show fit	0.82	ENST00000541574.1	RP13-941N14.1 Ensembl NCBI GeneCards UniProt Show fit	RP13-941N14.1
chr4_+_1714548 Show fit	0.77	ENST00000605571.1	RP11-572O17.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-572O17.1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FLI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0002279	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0	2.3	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.1	2.0	GO:0042424	catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1	2.0	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.0	2.0	GO:0051496	positive regulation of stress fiber assembly(GO:0051496)
0.1	1.9	GO:0036150	phosphatidylserine acyl-chain remodeling(GO:0036150)
0.1	1.4	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
0.1	1.4	GO:0038203	TORC2 signaling(GO:0038203)
0.1	1.3	GO:0015886	heme transport(GO:0015886)
0.0	1.2	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)

Showing 1 to 10 of 394 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	GO:0002102	podosome(GO:0002102)
0.1	2.7	GO:0042629	mast cell granule(GO:0042629)
0.1	1.6	GO:0000346	transcription export complex(GO:0000346)
0.0	1.3	GO:0031201	SNARE complex(GO:0031201)
0.0	1.2	GO:0016592	mediator complex(GO:0016592)
0.0	1.1	GO:0031932	TORC2 complex(GO:0031932)
0.1	1.0	GO:0097443	sorting endosome(GO:0097443)
0.0	1.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	1.0	GO:0005801	cis-Golgi network(GO:0005801)
0.2	0.9	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)

Showing 1 to 10 of 152 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0017124	SH3 domain binding(GO:0017124)
0.0	2.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	2.1	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.2	2.0	GO:0016206	catechol O-methyltransferase activity(GO:0016206)
0.0	1.4	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	1.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	1.3	GO:0030621	U4 snRNA binding(GO:0030621)
0.1	1.3	GO:0008142	oxysterol binding(GO:0008142)
0.1	1.3	GO:0015232	heme transporter activity(GO:0015232)
0.1	1.3	GO:0030306	ADP-ribosylation factor binding(GO:0030306)

Showing 1 to 10 of 216 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	2.4	PID AURORA A PATHWAY	Aurora A signaling
0.0	1.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.3	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	1.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	1.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	1.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events

Showing 1 to 10 of 34 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
3.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.9	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
1.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.1	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
1.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
1.1	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
1.0	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions

Showing 1 to 10 of 66 entries

Results for FLI1

Z-value: 1.51

Motif logo

Transcription factors associated with FLI1

Activity-expression correlation:

Activity profile of FLI1 motif

Sorted Z-values of FLI1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FLI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: