ISMARA results: EZH2

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EZH2

Z-value: 2.40

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Transcription factors associated with EZH2

Gene Symbol	Gene ID	Gene Info
EZH2 Ensembl NCBI GeneCards UniProt	ENSG00000106462.6	enhancer of zeste 2 polycomb repressive complex 2 subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EZH2	hg19_v2_chr7_-_148581360_148581425	0.38	4.5e-01	Click!

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_92919043 Show fit	2.50	ENST00000327111.3	NR2F1 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 2, group F, member 1
chr6_-_170151603 Show fit	1.83	ENST00000366774.3	TCTE3 Ensembl NCBI GeneCards UniProt Show fit	t-complex-associated-testis-expressed 3
chr2_+_11864458 Show fit	1.68	ENST00000396098.1 ENST00000396099.1 ENST00000425416.2	LPIN1 Ensembl NCBI GeneCards UniProt Show fit	lipin 1
chr5_+_175298674 Show fit	1.67	ENST00000514150.1	CPLX2 Ensembl NCBI GeneCards UniProt Show fit	complexin 2
chr5_+_175298573 Show fit	1.59	ENST00000512824.1	CPLX2 Ensembl NCBI GeneCards UniProt Show fit	complexin 2
chr1_+_95975672 Show fit	1.56	ENST00000440116.2 ENST00000456933.1	RP11-286B14.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-286B14.1
chr19_-_4338783 Show fit	1.51	ENST00000601482.1 ENST00000600324.1	STAP2 Ensembl NCBI GeneCards UniProt Show fit	signal transducing adaptor family member 2
chr11_+_6226782 Show fit	1.51	ENST00000316375.2	C11orf42 Ensembl NCBI GeneCards UniProt Show fit	chromosome 11 open reading frame 42
chr17_-_46692287 Show fit	1.45	ENST00000239144.4	HOXB8 Ensembl NCBI GeneCards UniProt Show fit	homeobox B8
chr5_+_158527630 Show fit	1.41	ENST00000523301.1	RP11-175K6.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-175K6.1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.6	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.1	2.3	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.7	2.0	GO:0001172	transcription, RNA-templated(GO:0001172)
0.2	2.0	GO:1990834	response to odorant(GO:1990834)
0.1	1.9	GO:0021692	cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1	1.8	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.4	1.7	GO:0098582	innate vocalization behavior(GO:0098582)
0.2	1.7	GO:0006642	triglyceride mobilization(GO:0006642)
0.1	1.7	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.0	1.7	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)

Showing 1 to 10 of 362 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.2	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0	4.2	GO:0001726	ruffle(GO:0001726)
0.0	3.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	2.6	GO:0008091	spectrin(GO:0008091)
0.0	2.5	GO:0030286	dynein complex(GO:0030286)
0.0	2.3	GO:0005923	bicellular tight junction(GO:0005923)
0.2	2.0	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.1	2.0	GO:0000974	Prp19 complex(GO:0000974)
0.0	1.7	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.5	1.6	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)

Showing 1 to 10 of 130 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	2.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.3	2.7	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	2.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2	2.3	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	2.2	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	2.1	GO:0017166	vinculin binding(GO:0017166)
0.7	2.0	GO:0003968	RNA-directed RNA polymerase activity(GO:0003968)
0.0	2.0	GO:0003774	motor activity(GO:0003774)
0.3	1.7	GO:0008195	phosphatidate phosphatase activity(GO:0008195)

Showing 1 to 10 of 228 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
2.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
2.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
2.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
1.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
1.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
1.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.3	PID REELIN PATHWAY	Reelin signaling pathway
1.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
1.3	PID CMYB PATHWAY	C-MYB transcription factor network

Showing 1 to 10 of 59 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	3.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	2.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	2.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	2.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	2.2	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	1.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	1.8	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.7	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	1.6	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis

Showing 1 to 10 of 64 entries

Results for EZH2

Z-value: 2.40

Motif logo

Transcription factors associated with EZH2

Activity-expression correlation:

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: