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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ETV6
Z-value: 1.42
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Transcription factors associated with ETV6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV6 | hg19_v2_chr12_+_11802753_11802834 | 0.68 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_38004832 Show fit | 1.07 |
ENST00000405147.3
ENST00000429218.1 ENST00000325180.8 ENST00000337437.4 |
golgi-associated, gamma adaptin ear containing, ARF binding protein 1 |
|
| chr22_+_38004942 Show fit | 1.02 |
ENST00000439161.1
ENST00000449944.1 ENST00000411501.1 ENST00000453208.1 |
golgi-associated, gamma adaptin ear containing, ARF binding protein 1 |
|
| chr19_+_11670245 Show fit | 0.94 |
ENST00000585493.1
|
zinc finger protein 627 |
|
| chr17_+_45908974 Show fit | 0.87 |
ENST00000269025.4
|
leucine rich repeat containing 46 |
|
| chr6_-_31620455 Show fit | 0.83 |
ENST00000437771.1
ENST00000404765.2 ENST00000375964.6 ENST00000211379.5 |
BCL2-associated athanogene 6 |
|
| chr1_+_162336686 Show fit | 0.81 |
ENST00000420220.1
|
chromosome 1 open reading frame 226 |
|
| chr22_+_38004723 Show fit | 0.80 |
ENST00000381756.5
|
golgi-associated, gamma adaptin ear containing, ARF binding protein 1 |
|
| chr20_-_2821271 Show fit | 0.78 |
ENST00000448755.1
ENST00000360652.2 |
PC-esterase domain containing 1A |
|
| chr2_-_96971232 Show fit | 0.75 |
ENST00000323853.5
|
small nuclear ribonucleoprotein 200kDa (U5) |
|
| chr22_+_38004473 Show fit | 0.75 |
ENST00000414350.3
ENST00000343632.4 |
golgi-associated, gamma adaptin ear containing, ARF binding protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | GO:1901998 | toxin transport(GO:1901998) |
| 0.4 | 3.8 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 1.7 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 1.6 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.4 | 1.4 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.4 | 1.4 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.1 | 1.3 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.4 | 1.2 | GO:0000349 | generation of catalytic spliceosome for first transesterification step(GO:0000349) |
| 0.4 | 1.1 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.1 | 1.1 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.3 | 3.8 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 1.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.4 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.1 | 1.3 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 1.3 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.4 | 1.1 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.0 | 1.1 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 1.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 1.0 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.9 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 3.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.2 | 2.0 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.1 | 1.9 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 1.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.5 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 1.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 1.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 1.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.0 | GO:0070182 | DNA polymerase binding(GO:0070182) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.8 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 0.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 2.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.5 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 1.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.4 | REACTOME TELOMERE MAINTENANCE | Genes involved in Telomere Maintenance |
| 0.1 | 1.3 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.1 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.0 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 1.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |