ISMARA results: ESRRB

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ESRRB_ESRRG

Z-value: 0.87

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Transcription factors associated with ESRRB_ESRRG

Gene Symbol	Gene ID	Gene Info
ESRRB Ensembl NCBI GeneCards UniProt	ENSG00000119715.10	estrogen related receptor beta
ESRRG Ensembl NCBI GeneCards UniProt	ENSG00000196482.12	estrogen related receptor gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ESRRB	hg19_v2_chr14_+_76776957_76777061	-0.10	8.5e-01	Click!
ESRRG	hg19_v2_chr1_-_217311090_217311097	-0.04	9.4e-01	Click!

Activity profile of ESRRB_ESRRG motif

Sorted Z-values of ESRRB_ESRRG motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_28875126 Show fit	0.71	ENST00000359285.5 ENST00000538342.1	SH2B1 Ensembl NCBI GeneCards UniProt Show fit	SH2B adaptor protein 1
chr15_+_76352178 Show fit	0.58	ENST00000388942.3	C15orf27 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 27
chr16_+_777739 Show fit	0.56	ENST00000563792.1	HAGHL Ensembl NCBI GeneCards UniProt Show fit	hydroxyacylglutathione hydrolase-like
chr13_-_50020554 Show fit	0.56	ENST00000400396.1	AL136218.1 Ensembl NCBI GeneCards UniProt Show fit	Sarcoma antigen NY-SAR-79; Uncharacterized protein
chr4_+_119512928 Show fit	0.55	ENST00000567913.2	RP11-384K6.6 Ensembl NCBI GeneCards UniProt Show fit	RP11-384K6.6
chr3_-_117716418 Show fit	0.55	ENST00000484092.1	RP11-384F7.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-384F7.2
chr18_-_56985776 Show fit	0.54	ENST00000587244.1	CPLX4 Ensembl NCBI GeneCards UniProt Show fit	complexin 4
chr12_-_24737089 Show fit	0.52	ENST00000483544.1	LINC00477 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 477
chr17_-_27503770 Show fit	0.52	ENST00000533112.1	MYO18A Ensembl NCBI GeneCards UniProt Show fit	myosin XVIIIA
chr1_-_12679171 Show fit	0.51	ENST00000606790.1	RP11-474O21.5 Ensembl NCBI GeneCards UniProt Show fit	RP11-474O21.5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ESRRB_ESRRG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0045840	positive regulation of mitotic nuclear division(GO:0045840)
0.0	0.9	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.7	GO:0045974	miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.2	0.6	GO:0015743	thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.2	0.6	GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1	0.6	GO:0006218	uridine catabolic process(GO:0006218)
0.1	0.6	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.6	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2	0.5	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1	0.5	GO:1903028	positive regulation of opsonization(GO:1903028)

Showing 1 to 10 of 134 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0042599	lamellar body(GO:0042599)
0.1	0.5	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1	0.5	GO:1990130	Iml1 complex(GO:1990130)
0.1	0.5	GO:0097452	GAIT complex(GO:0097452)
0.0	0.5	GO:0045202	synapse(GO:0045202)
0.1	0.4	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.4	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.4	GO:0032010	phagolysosome(GO:0032010)
0.0	0.3	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.3	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.3	GO:0033867	Fas-activated serine/threonine kinase activity(GO:0033867)
0.0	1.0	GO:0043531	ADP binding(GO:0043531)
0.0	0.8	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.8	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.8	GO:0004177	aminopeptidase activity(GO:0004177)
0.2	0.6	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.2	0.6	GO:0015117	thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1	0.6	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.1	0.6	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.6	GO:0016018	cyclosporin A binding(GO:0016018)

Showing 1 to 10 of 90 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.9	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7	PID TRAIL PATHWAY	TRAIL signaling pathway
0.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	PID ALK2 PATHWAY	ALK2 signaling events
0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	1.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.9	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.9	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.7	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.7	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.6	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.5	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.5	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.4	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection

Showing 1 to 10 of 21 entries

Results for ESRRB_ESRRG

Z-value: 0.87

Motif logo

Transcription factors associated with ESRRB_ESRRG

Activity-expression correlation:

Activity profile of ESRRB_ESRRG motif

Sorted Z-values of ESRRB_ESRRG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ESRRB_ESRRG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: