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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ERG
Z-value: 1.07
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Transcription factors associated with ERG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_144665237 Show fit | 1.43 |
ENST00000421035.2
|
utrophin |
|
| chr19_-_51875894 Show fit | 1.02 |
ENST00000600427.1
ENST00000595217.1 ENST00000221978.5 |
natural killer cell group 7 sequence |
|
| chr22_+_27068704 Show fit | 0.94 |
ENST00000444388.1
ENST00000450963.1 ENST00000449017.1 |
CTA-211A9.5 |
|
| chr16_+_4845379 Show fit | 0.86 |
ENST00000588606.1
ENST00000586005.1 |
small integral membrane protein 22 |
|
| chr11_+_2421718 Show fit | 0.84 |
ENST00000380996.5
ENST00000333256.6 ENST00000380992.1 ENST00000437110.1 ENST00000435795.1 |
tumor suppressing subtransferable candidate 4 |
|
| chr13_+_111855399 Show fit | 0.69 |
ENST00000426768.2
|
Rho guanine nucleotide exchange factor (GEF) 7 |
|
| chr2_+_239335636 Show fit | 0.66 |
ENST00000409297.1
|
ankyrin repeat and SOCS box containing 1 |
|
| chr12_+_122018697 Show fit | 0.65 |
ENST00000541574.1
|
RP13-941N14.1 |
|
| chr4_+_165675197 Show fit | 0.63 |
ENST00000515485.1
|
RP11-294O2.2 |
|
| chr19_-_46526304 Show fit | 0.61 |
ENST00000008938.4
|
peptidoglycan recognition protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ERG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 1.7 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 1.3 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.1 | 1.3 | GO:2000394 | positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.0 | 1.3 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.0 | 1.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 1.2 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.1 | 1.1 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.1 | 1.1 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 1.1 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.9 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 1.4 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 1.3 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.1 | 1.3 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 1.2 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 1.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 1.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.2 | 1.0 | GO:1903439 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 2.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.5 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 1.3 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 1.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.1 | 1.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 1.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.2 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.2 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 1.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.0 | 1.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.1 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.8 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 0.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.8 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.7 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |