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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for EP300
Z-value: 1.23
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Transcription factors associated with EP300
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EP300 | hg19_v2_chr22_+_41487711_41487798 | 0.19 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_20866424 Show fit | 1.11 |
ENST00000272224.3
|
growth differentiation factor 7 |
|
| chr13_-_44361025 Show fit | 0.60 |
ENST00000261488.6
|
ecto-NOX disulfide-thiol exchanger 1 |
|
| chr1_-_32827682 Show fit | 0.57 |
ENST00000432622.1
|
family with sequence similarity 229, member A |
|
| chr20_-_19738569 Show fit | 0.53 |
ENST00000598007.1
|
Uncharacterized protein |
|
| chr11_+_46722368 Show fit | 0.52 |
ENST00000311764.2
|
zinc finger protein 408 |
|
| chr17_+_43238438 Show fit | 0.51 |
ENST00000593138.1
ENST00000586681.1 |
hexamethylene bis-acetamide inducible 2 |
|
| chr3_-_126076264 Show fit | 0.47 |
ENST00000296233.3
|
Kruppel-like factor 15 |
|
| chr8_-_37594944 Show fit | 0.47 |
ENST00000330539.1
|
Uncharacterized protein |
|
| chr15_+_23810853 Show fit | 0.43 |
ENST00000568252.1
|
makorin ring finger protein 3 |
|
| chr16_-_31085033 Show fit | 0.42 |
ENST00000414399.1
|
zinc finger protein 668 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EP300
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0035992 | tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) |
| 0.1 | 0.7 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 0.7 | GO:0060356 | leucine import(GO:0060356) |
| 0.0 | 0.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 0.5 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
| 0.1 | 0.5 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 0.5 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.0 | 0.5 | GO:2000535 | regulation of entry of bacterium into host cell(GO:2000535) |
| 0.0 | 0.5 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.5 | GO:0061318 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.5 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.1 | 0.5 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 0.4 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.4 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.4 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.3 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.7 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.6 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.5 | GO:0036435 | IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435) |
| 0.0 | 0.5 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 0.5 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 0.5 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.0 | 0.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.5 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.4 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.4 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 0.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |