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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for EOMES
Z-value: 1.30
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Transcription factors associated with EOMES
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EOMES | hg19_v2_chr3_-_27764190_27764208 | -0.33 | 5.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EOMES
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.5 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.1 | 0.9 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.0 | 0.9 | GO:0051298 | centrosome duplication(GO:0051298) |
| 0.2 | 0.8 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.1 | 0.8 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 0.8 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.0 | 0.8 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.1 | 0.7 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.0 | 0.7 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.2 | 0.6 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 0.8 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 0.8 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.6 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.6 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 1.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 0.9 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.0 | 0.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.7 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 0.7 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.6 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.6 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.4 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |