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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EN1_ESX1_GBX1

Z-value: 0.82

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Transcription factors associated with EN1_ESX1_GBX1

Gene Symbol Gene ID Gene Info
EN1
ENSG00000163064.6 engrailed homeobox 1
ESX1
ENSG00000123576.5 ESX homeobox 1
GBX1
ENSG00000164900.4 gastrulation brain homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GBX1hg19_v2_chr7_-_150864635_1508647850.246.5e-01Click!
EN1hg19_v2_chr2_-_119605253_119605264-0.236.6e-01Click!
ESX1hg19_v2_chrX_-_103499602_1034996170.059.2e-01Click!

Activity profile of EN1_ESX1_GBX1 motif

Sorted Z-values of EN1_ESX1_GBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_27998689 3.35 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr7_-_92777606 0.84 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr17_-_38821373 0.76 ENST00000394052.3
KRT222
keratin 222
chr1_+_244515930 0.71 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr8_-_128231299 0.70 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr22_+_46476192 0.65 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr15_+_63188009 0.65 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr1_+_209878182 0.61 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr14_-_51027838 0.58 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr17_+_19091325 0.57 ENST00000584923.1
SNORD3A
small nucleolar RNA, C/D box 3A
chrM_+_8366 0.47 ENST00000361851.1
MT-ATP8
mitochondrially encoded ATP synthase 8
chr4_+_66536248 0.45 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr12_-_89746264 0.44 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr17_+_61151306 0.41 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr9_-_5339873 0.41 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr17_-_19015945 0.40 ENST00000573866.2
SNORD3D
small nucleolar RNA, C/D box 3D
chr9_-_3469181 0.38 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr6_+_130339710 0.37 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr17_+_59489112 0.37 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr12_+_72058130 0.36 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr18_-_71959159 0.34 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
CYB5A
cytochrome b5 type A (microsomal)
chrM_+_10464 0.33 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr12_+_78359999 0.33 ENST00000550503.1
NAV3
neuron navigator 3
chr17_-_39341594 0.29 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr12_+_28410128 0.28 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr2_-_224467002 0.28 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr2_+_149402989 0.27 ENST00000397424.2
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr11_+_77532233 0.27 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr7_-_73038822 0.27 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr8_+_32579271 0.26 ENST00000518084.1
NRG1
neuregulin 1
chr1_+_207277632 0.25 ENST00000421786.1
C4BPA
complement component 4 binding protein, alpha
chr7_-_33102399 0.25 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr8_+_119294456 0.25 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr11_-_117747434 0.25 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr6_-_18264406 0.25 ENST00000515742.1
DEK
DEK oncogene
chr17_-_40337470 0.25 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr13_-_86373536 0.25 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr11_+_35222629 0.24 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr6_-_32157947 0.24 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chrX_+_591524 0.24 ENST00000554971.1
ENST00000381575.1
SHOX
short stature homeobox
chr7_+_6655225 0.24 ENST00000457543.3
ZNF853
zinc finger protein 853
chr10_-_93392811 0.23 ENST00000238994.5
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr12_+_1099675 0.23 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr7_-_33102338 0.23 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr19_-_6737576 0.23 ENST00000601716.1
ENST00000264080.7
GPR108
G protein-coupled receptor 108
chr1_-_242612726 0.23 ENST00000459864.1
PLD5
phospholipase D family, member 5
chr11_-_121986923 0.23 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr17_-_38928414 0.22 ENST00000335552.4
KRT26
keratin 26
chr8_-_40755333 0.22 ENST00000297737.6
ENST00000315769.7
ZMAT4
zinc finger, matrin-type 4
chr19_-_7698599 0.22 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr12_-_74686314 0.22 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr19_-_7968427 0.22 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr12_+_52695617 0.22 ENST00000293525.5
KRT86
keratin 86
chr1_-_235098861 0.21 ENST00000458044.1
RP11-443B7.1
RP11-443B7.1
chr6_-_33663474 0.21 ENST00000594414.1
SBP1
SBP1; Uncharacterized protein
chr12_-_10007448 0.21 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr5_+_136070614 0.21 ENST00000502421.1
CTB-1I21.1
CTB-1I21.1
chr14_+_67831576 0.21 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr6_-_26199499 0.21 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr13_-_96329048 0.20 ENST00000606011.1
ENST00000499499.2
DNAJC3-AS1
DNAJC3 antisense RNA 1 (head to head)
chr14_+_101359265 0.20 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr4_-_89205705 0.20 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr1_-_68698222 0.20 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr3_+_157154578 0.20 ENST00000295927.3
PTX3
pentraxin 3, long
chr1_-_235098935 0.20 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr12_-_10022735 0.19 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr4_+_77941685 0.19 ENST00000506731.1
SEPT11
septin 11
chr11_+_34663913 0.19 ENST00000532302.1
EHF
ets homologous factor
chr4_+_183065793 0.19 ENST00000512480.1
TENM3
teneurin transmembrane protein 3
chr12_+_7014126 0.18 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr3_+_130569429 0.18 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr4_+_95916947 0.18 ENST00000506363.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr4_+_70894130 0.18 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr15_+_63682335 0.18 ENST00000559379.1
ENST00000559821.1
RP11-321G12.1
RP11-321G12.1
chr13_+_78315348 0.18 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr20_+_18447771 0.18 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr1_+_101003687 0.18 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chrM_+_10758 0.18 ENST00000361381.2
MT-ND4
mitochondrially encoded NADH dehydrogenase 4
chr2_-_145188137 0.17 ENST00000440875.1
ZEB2
zinc finger E-box binding homeobox 2
chr22_+_18632666 0.17 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chrX_-_71458802 0.17 ENST00000373657.1
ENST00000334463.3
ERCC6L
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr12_-_28123206 0.17 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chrX_+_134654540 0.17 ENST00000370752.4
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr17_+_62223320 0.17 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr6_-_26199471 0.17 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr7_-_99716914 0.17 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_-_102455801 0.17 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr5_+_148737562 0.17 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr4_-_109541539 0.17 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr9_-_16728161 0.17 ENST00000603713.1
ENST00000603313.1
BNC2
basonuclin 2
chr10_+_35484793 0.17 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr13_-_41593425 0.17 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr14_-_104181771 0.16 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr10_+_13628933 0.16 ENST00000417658.1
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr2_+_170440844 0.16 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr8_-_74495065 0.16 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr17_+_43238438 0.16 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr1_-_118472171 0.16 ENST00000369442.3
GDAP2
ganglioside induced differentiation associated protein 2
chr5_+_31193847 0.15 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr5_+_137673200 0.15 ENST00000434981.2
FAM53C
family with sequence similarity 53, member C
chr14_+_62037287 0.15 ENST00000556569.1
RP11-47I22.3
Uncharacterized protein
chr1_+_68150744 0.15 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr12_-_94673956 0.15 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr7_+_77428149 0.15 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr11_-_33913708 0.15 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chrX_-_106243451 0.15 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr10_-_128110441 0.15 ENST00000456514.1
LINC00601
long intergenic non-protein coding RNA 601
chr4_-_39979576 0.15 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr17_-_64225508 0.15 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_160370344 0.15 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr1_+_151739131 0.14 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chrM_+_7586 0.14 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr5_-_24645078 0.14 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr4_+_129732419 0.14 ENST00000510308.1
PHF17
jade family PHD finger 1
chr1_+_62901968 0.14 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
USP1
ubiquitin specific peptidase 1
chr12_-_89746173 0.14 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr4_+_95128748 0.14 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr19_-_7697857 0.14 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr2_-_188419078 0.14 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_-_140714430 0.14 ENST00000393008.3
MRPS33
mitochondrial ribosomal protein S33
chr7_-_87342564 0.14 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_+_15604513 0.14 ENST00000481540.1
ZNF286A
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA.
chr8_+_32579321 0.14 ENST00000522402.1
NRG1
neuregulin 1
chr14_+_62164340 0.13 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr3_-_123339343 0.13 ENST00000578202.1
MYLK
myosin light chain kinase
chr2_-_145277569 0.13 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr19_+_23257988 0.13 ENST00000594318.1
ENST00000600223.1
ENST00000593635.1
CTD-2291D10.4
ZNF730
CTD-2291D10.4
zinc finger protein 730
chr19_+_50016411 0.13 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chrX_-_106243294 0.13 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr8_-_19614810 0.13 ENST00000524213.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr14_+_24616588 0.13 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr11_+_34654011 0.12 ENST00000531794.1
EHF
ets homologous factor
chrM_+_8527 0.12 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr13_-_36788718 0.12 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr19_-_6737241 0.12 ENST00000430424.4
ENST00000597298.1
GPR108
G protein-coupled receptor 108
chr12_-_51422017 0.12 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr12_+_16500037 0.12 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr14_-_24616426 0.12 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_-_201140673 0.12 ENST00000367333.2
TMEM9
transmembrane protein 9
chr10_+_94451574 0.12 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr7_-_99716940 0.12 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_210501589 0.12 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr1_+_117544366 0.12 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr12_-_118628315 0.12 ENST00000540561.1
TAOK3
TAO kinase 3
chr1_-_36916066 0.12 ENST00000315643.9
OSCP1
organic solute carrier partner 1
chr22_+_38054721 0.12 ENST00000215904.6
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr19_+_4153598 0.12 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr16_-_29910853 0.11 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr17_-_38956205 0.11 ENST00000306658.7
KRT28
keratin 28
chr19_+_36239576 0.11 ENST00000587751.1
LIN37
lin-37 homolog (C. elegans)
chr2_-_136678123 0.11 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr12_-_28122980 0.11 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chr1_-_21625486 0.11 ENST00000481130.2
ECE1
endothelin converting enzyme 1
chr3_+_179322481 0.11 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr6_-_72130472 0.11 ENST00000426635.2
LINC00472
long intergenic non-protein coding RNA 472
chr5_+_142286887 0.11 ENST00000451259.1
ARHGAP26
Rho GTPase activating protein 26
chr2_+_169926047 0.11 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr20_+_32782375 0.11 ENST00000568305.1
ASIP
agouti signaling protein
chr15_+_80351910 0.11 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr6_+_26020672 0.11 ENST00000357647.3
HIST1H3A
histone cluster 1, H3a
chr1_-_10532531 0.11 ENST00000377036.2
ENST00000377038.3
DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr12_-_50643664 0.11 ENST00000550592.1
LIMA1
LIM domain and actin binding 1
chr5_+_81601166 0.11 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr4_+_144312659 0.10 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr15_-_43785274 0.10 ENST00000413546.1
TP53BP1
tumor protein p53 binding protein 1
chr14_-_37051798 0.10 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr4_+_119200215 0.10 ENST00000602573.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr14_-_23762777 0.10 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr20_+_43990576 0.10 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr12_-_14849470 0.10 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr18_-_33709268 0.10 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr12_-_53171128 0.10 ENST00000332411.2
KRT76
keratin 76
chr14_-_23426231 0.10 ENST00000556915.1
HAUS4
HAUS augmin-like complex, subunit 4
chr12_-_16760021 0.10 ENST00000540445.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_36245561 0.10 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_70653673 0.10 ENST00000512870.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr16_+_69345243 0.10 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr11_-_102709441 0.10 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_+_54569968 0.10 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr11_-_36619771 0.10 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr10_-_104866395 0.10 ENST00000458345.1
NT5C2
5'-nucleotidase, cytosolic II
chr2_-_227050079 0.10 ENST00000423838.1
AC068138.1
AC068138.1
chr13_-_28545276 0.10 ENST00000381020.7
CDX2
caudal type homeobox 2
chr3_-_143567262 0.10 ENST00000474151.1
ENST00000316549.6
SLC9A9
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr7_+_12727250 0.10 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr20_-_50722183 0.10 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr1_-_22215192 0.10 ENST00000374673.3
HSPG2
heparan sulfate proteoglycan 2
chrX_-_102510120 0.09 ENST00000451678.1
TCEAL8
transcription elongation factor A (SII)-like 8
chr1_+_118472343 0.09 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr8_-_90996459 0.09 ENST00000517337.1
ENST00000409330.1
NBN
nibrin
chr2_+_202047843 0.09 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
CASP10
caspase 10, apoptosis-related cysteine peptidase
chrX_-_13835147 0.09 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr1_-_78444776 0.09 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr2_+_149447783 0.09 ENST00000449013.1
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr17_-_39123144 0.09 ENST00000355612.2
KRT39
keratin 39
chr6_+_64345698 0.09 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr2_+_211342400 0.09 ENST00000417946.1
ENST00000518043.1
ENST00000523702.1
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr3_+_167453493 0.09 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr2_+_172778952 0.09 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr3_-_112360116 0.09 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.6 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.2 GO:0061743 motor learning(GO:0061743)
0.1 0.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.2 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.2 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.1 0.5 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:0070101 positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 0.1 GO:0070408 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.0 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986) oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.3 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.6 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.3 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.0 0.2 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.2 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.0 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0042421 noradrenergic neuron differentiation(GO:0003357) norepinephrine biosynthetic process(GO:0042421)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.2 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.0 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.0 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.0 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0006789 bilirubin conjugation(GO:0006789)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.0 0.2 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.5 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.5 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.2 GO:0031852 opioid receptor binding(GO:0031628) mu-type opioid receptor binding(GO:0031852)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.0 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation