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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ELF2_GABPA_ELF5
Z-value: 1.01
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Transcription factors associated with ELF2_GABPA_ELF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000109381.15 | E74 like ETS transcription factor 2 | |
| ENSG00000154727.6 | GA binding protein transcription factor subunit alpha | |
| ENSG00000135374.5 | E74 like ETS transcription factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GABPA | hg19_v2_chr21_+_27107672_27107698 | 0.90 | 1.5e-02 | Click! |
| ELF2 | hg19_v2_chr4_-_140098339_140098392 | 0.83 | 4.0e-02 | Click! |
| ELF5 | hg19_v2_chr11_-_34535297_34535317 | 0.16 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_153700864 Show fit | 1.42 |
ENST00000304337.2
|
tigger transposable element derived 4 |
|
| chr5_+_82373379 Show fit | 1.42 |
ENST00000396027.4
ENST00000511817.1 |
X-ray repair complementing defective repair in Chinese hamster cells 4 |
|
| chr5_+_82373317 Show fit | 1.31 |
ENST00000282268.3
ENST00000338635.6 |
X-ray repair complementing defective repair in Chinese hamster cells 4 |
|
| chr21_+_38338737 Show fit | 1.20 |
ENST00000430068.1
|
AP000704.5 |
|
| chr7_-_108209897 Show fit | 1.18 |
ENST00000313516.5
|
THAP domain containing 5 |
|
| chr1_+_169337172 Show fit | 1.17 |
ENST00000367807.3
ENST00000367808.3 ENST00000329281.2 ENST00000420531.1 |
basic leucine zipper nuclear factor 1 |
|
| chr12_+_100594557 Show fit | 1.16 |
ENST00000546902.1
ENST00000552376.1 ENST00000551617.1 |
ARP6 actin-related protein 6 homolog (yeast) |
|
| chr15_+_71185148 Show fit | 1.13 |
ENST00000443425.2
ENST00000560755.1 |
leucine rich repeat containing 49 |
|
| chr11_+_313503 Show fit | 1.11 |
ENST00000528780.1
ENST00000328221.5 |
interferon induced transmembrane protein 1 |
|
| chr5_+_158690089 Show fit | 1.10 |
ENST00000296786.6
|
ubiquitin-like domain containing CTD phosphatase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.1 | 3.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 3.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.3 | 2.4 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.0 | 2.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.3 | 2.3 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 2.3 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 2.2 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.0 | 2.2 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.1 | 2.1 | GO:0035455 | response to interferon-alpha(GO:0035455) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.6 | 3.3 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.3 | 3.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 2.6 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 2.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 2.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 1.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 1.7 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 1.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.4 | 1.5 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 2.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 2.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 2.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.9 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.1 | 1.9 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 1.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 1.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.4 | 1.5 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 2.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 2.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 4.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.6 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.1 | 3.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 3.1 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 3.0 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 3.0 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 2.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 2.7 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 2.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |