Project
A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for EGR1_EGR4
Z-value: 0.99
Motif logo
Transcription factors associated with EGR1_EGR4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR1 | hg19_v2_chr5_+_137801160_137801179 | 0.77 | 7.2e-02 | Click! |
| EGR4 | hg19_v2_chr2_-_73520667_73520833 | -0.33 | 5.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.1 | 1.2 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.0 | 1.1 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 1.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.1 | 1.0 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.3 | 0.9 | GO:0071264 | regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264) |
| 0.2 | 0.9 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.1 | 0.9 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.0 | 0.9 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.3 | 0.8 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.8 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 0.7 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.7 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.7 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.6 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.6 | GO:0097227 | sperm annulus(GO:0097227) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 1.6 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.1 | 1.4 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.1 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.0 | 1.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.2 | 0.9 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.0 | 0.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.1 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 0.9 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.8 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 0.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.6 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 0.6 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |