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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for EBF3
Z-value: 1.62
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Transcription factors associated with EBF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF3 | hg19_v2_chr10_-_131640435_131640435 | 0.23 | 6.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_38065052 Show fit | 1.02 |
ENST00000556845.1
|
tetratricopeptide repeat domain 6 |
|
| chr7_-_100881041 Show fit | 0.96 |
ENST00000412417.1
ENST00000414035.1 |
claudin 15 |
|
| chr2_+_238499812 Show fit | 0.92 |
ENST00000452801.1
|
AC104667.3 |
|
| chr1_-_41950342 Show fit | 0.88 |
ENST00000372587.4
|
endothelin 2 |
|
| chr11_+_20044375 Show fit | 0.88 |
ENST00000525322.1
ENST00000530408.1 |
neuron navigator 2 |
|
| chr15_-_40633101 Show fit | 0.88 |
ENST00000559313.1
|
chromosome 15 open reading frame 52 |
|
| chr1_+_23695680 Show fit | 0.80 |
ENST00000454117.1
ENST00000335648.3 ENST00000518821.1 ENST00000437367.2 |
chromosome 1 open reading frame 213 |
|
| chr19_+_45909893 Show fit | 0.76 |
ENST00000592852.1
ENST00000589804.1 ENST00000590794.1 |
CD3e molecule, epsilon associated protein |
|
| chr17_+_27052892 Show fit | 0.75 |
ENST00000579671.1
ENST00000579060.1 |
NIMA-related kinase 8 |
|
| chr12_-_106697974 Show fit | 0.74 |
ENST00000553039.1
|
cytoskeleton-associated protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) |
| 0.0 | 1.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.2 | 1.2 | GO:0060611 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141) |
| 0.1 | 1.2 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.0 | 1.1 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 1.1 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 1.0 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.2 | 0.9 | GO:0060585 | regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.0 | 0.9 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.9 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 1.2 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 1.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.0 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.3 | 0.8 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.1 | 0.8 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.0 | 0.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.2 | 0.7 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 0.7 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.7 | GO:0032433 | filopodium tip(GO:0032433) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.2 | 1.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.1 | 1.2 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 1.1 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.2 | 0.9 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.0 | 0.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 0.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.8 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.8 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 0.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.7 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |