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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for EBF1
Z-value: 1.71
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Transcription factors associated with EBF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF1 | hg19_v2_chr5_-_158526693_158526706 | 0.83 | 4.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_74212073 Show fit | 1.33 |
ENST00000441217.1
|
AC073046.25 |
|
| chr17_-_77967433 Show fit | 1.15 |
ENST00000571872.1
|
TBC1 domain family, member 16 |
|
| chr17_+_73539232 Show fit | 1.08 |
ENST00000580925.1
|
lethal giant larvae homolog 2 (Drosophila) |
|
| chr7_-_100881041 Show fit | 0.96 |
ENST00000412417.1
ENST00000414035.1 |
claudin 15 |
|
| chr22_-_23922410 Show fit | 0.88 |
ENST00000249053.3
|
immunoglobulin lambda-like polypeptide 1 |
|
| chr6_-_31651817 Show fit | 0.88 |
ENST00000375863.3
ENST00000375860.2 |
lymphocyte antigen 6 complex, locus G5C |
|
| chr19_+_7981030 Show fit | 0.83 |
ENST00000565886.1
|
transforming growth factor, beta receptor III-like |
|
| chr19_+_48949087 Show fit | 0.82 |
ENST00000598711.1
|
glutamate-rich WD repeat containing 1 |
|
| chr14_+_38065052 Show fit | 0.81 |
ENST00000556845.1
|
tetratricopeptide repeat domain 6 |
|
| chr2_-_27531313 Show fit | 0.80 |
ENST00000296099.2
|
urocortin |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.1 | 2.0 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.2 | 1.8 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.1 | 1.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 1.6 | GO:0032785 | negative regulation of DNA-templated transcription, elongation(GO:0032785) |
| 0.0 | 1.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 1.4 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.2 | 1.3 | GO:0097473 | cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.1 | 1.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 1.3 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 2.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 2.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.3 | 1.6 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.0 | 1.5 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 1.0 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 1.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 1.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 1.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 1.0 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 1.0 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 1.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 1.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.1 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.7 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 1.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.7 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.2 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |