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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E4F1

Z-value: 0.46

Motif logo

Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
ENSG00000167967.11 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273645_22737170.796.3e-02Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_184053703 0.25 ENST00000450976.1
ENST00000418281.1
ENST00000340957.5
ENST00000433578.1
family with sequence similarity 131, member A
chr20_+_33146510 0.24 ENST00000397709.1
microtubule-associated protein 1 light chain 3 alpha
chr3_-_107941209 0.20 ENST00000492106.1
intraflagellar transport 57 homolog (Chlamydomonas)
chr7_-_86849836 0.20 ENST00000455575.1
transmembrane protein 243, mitochondrial
chr6_+_32812568 0.20 ENST00000414474.1
proteasome (prosome, macropain) subunit, beta type, 9
chr14_-_23388338 0.20 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RNA binding motif protein 23
chr17_+_53342311 0.16 ENST00000226067.5
hepatic leukemia factor
chr2_-_157189180 0.15 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
nuclear receptor subfamily 4, group A, member 2
chr17_-_36831156 0.15 ENST00000325814.5
chromosome 17 open reading frame 96
chr19_+_45504688 0.13 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr1_+_26496362 0.13 ENST00000374266.5
ENST00000270812.5
zinc finger protein 593
chr6_-_34664612 0.13 ENST00000374023.3
ENST00000374026.3
chromosome 6 open reading frame 106
chr19_+_1941117 0.13 ENST00000255641.8
casein kinase 1, gamma 2
chr18_+_23806437 0.12 ENST00000578121.1
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr19_-_10024496 0.12 ENST00000593091.1
olfactomedin 2
chr4_+_47487285 0.11 ENST00000273859.3
ENST00000504445.1
ATPase, class V, type 10D
chr17_-_80231557 0.11 ENST00000392334.2
ENST00000314028.6
casein kinase 1, delta
chr1_+_8378140 0.11 ENST00000377479.2
solute carrier family 45, member 1
chr11_-_6633799 0.11 ENST00000299424.4
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr18_+_23806382 0.11 ENST00000400466.2
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr14_+_94492674 0.10 ENST00000203664.5
ENST00000553723.1
OTU domain, ubiquitin aldehyde binding 2
chr19_+_10527449 0.10 ENST00000592685.1
ENST00000380702.2
phosphodiesterase 4A, cAMP-specific
chrX_+_153672468 0.10 ENST00000393600.3
family with sequence similarity 50, member A
chr1_-_70820357 0.10 ENST00000370944.4
ENST00000262346.6
ankyrin repeat domain 13C
chr16_+_68057153 0.10 ENST00000358896.6
ENST00000568099.2
dihydrouridine synthase 2
chr6_-_32812420 0.09 ENST00000374881.2
proteasome (prosome, macropain) subunit, beta type, 8
chr9_+_131644388 0.09 ENST00000372600.4
leucine rich repeat containing 8 family, member A
chr6_-_30523865 0.09 ENST00000433809.1
guanine nucleotide binding protein-like 1
chr17_+_18087553 0.09 ENST00000399138.4
alkB, alkylation repair homolog 5 (E. coli)
chr12_+_107168418 0.09 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8 guanine nucleotide exchange factor B
chrX_-_13835147 0.08 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr11_+_111411384 0.08 ENST00000375615.3
ENST00000525126.1
ENST00000436913.2
ENST00000533265.1
layilin
chr7_-_129592471 0.08 ENST00000473814.2
ENST00000490974.1
ubiquitin-conjugating enzyme E2H
chr16_+_68056844 0.08 ENST00000565263.1
dihydrouridine synthase 2
chr7_-_100026280 0.08 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chr20_-_44600810 0.08 ENST00000322927.2
ENST00000426788.1
zinc finger protein 335
chr12_+_122516626 0.08 ENST00000319080.7
MLX interacting protein
chr17_+_71161140 0.08 ENST00000357585.2
somatostatin receptor 2
chr20_-_44420507 0.08 ENST00000243938.4
WAP four-disulfide core domain 3
chr8_-_94928861 0.08 ENST00000607097.1
microRNA 378d-2
chr1_-_16482554 0.07 ENST00000358432.5
EPH receptor A2
chr17_+_685513 0.07 ENST00000304478.4
RNA methyltransferase like 1
chr19_+_54705025 0.07 ENST00000441429.1
ribosomal protein S9
chr8_-_66754172 0.07 ENST00000401827.3
phosphodiesterase 7A
chr22_-_38902300 0.07 ENST00000403230.1
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr3_+_150126101 0.07 ENST00000361875.3
ENST00000361136.2
TSC22 domain family, member 2
chr1_+_70820451 0.07 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HERV-H LTR-associating 3
chr1_+_85527987 0.07 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WD repeat domain 63
chr16_-_27561209 0.07 ENST00000356183.4
ENST00000561623.1
general transcription factor IIIC, polypeptide 1, alpha 220kDa
chr4_-_111558135 0.07 ENST00000394598.2
ENST00000394595.3
paired-like homeodomain 2
chr6_+_30029008 0.07 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
zinc ribbon domain containing 1
chr19_+_13858701 0.06 ENST00000586666.1
coiled-coil domain containing 130
chr19_-_46088068 0.06 ENST00000263275.4
ENST00000323060.3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr20_+_58179582 0.06 ENST00000371015.1
ENST00000395639.4
phosphatase and actin regulator 3
chr9_+_131644398 0.06 ENST00000372599.3
leucine rich repeat containing 8 family, member A
chr17_+_41476327 0.06 ENST00000320033.4
ADP-ribosylation factor-like 4D
chr16_+_68057179 0.06 ENST00000567100.1
ENST00000432752.1
ENST00000569289.1
ENST00000564781.1
dihydrouridine synthase 2
chr4_+_75310851 0.06 ENST00000395748.3
ENST00000264487.2
amphiregulin
chr4_+_75311019 0.06 ENST00000502307.1
amphiregulin
chr6_-_47445214 0.06 ENST00000604014.1
RP11-385F7.1
chr9_+_131644781 0.06 ENST00000259324.5
leucine rich repeat containing 8 family, member A
chr20_+_44420570 0.06 ENST00000372622.3
deoxynucleotidyltransferase, terminal, interacting protein 1
chr3_-_134092561 0.05 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
angiomotin like 2
chr19_+_54704610 0.05 ENST00000302907.4
ribosomal protein S9
chr17_+_25621102 0.05 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WD repeat and SOCS box containing 1
chr22_+_18121356 0.05 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2-like 13 (apoptosis facilitator)
chr22_-_41252962 0.05 ENST00000216218.3
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr3_+_38206975 0.05 ENST00000446845.1
ENST00000311806.3
oxidative stress responsive 1
chr22_+_39101728 0.05 ENST00000216044.5
ENST00000484657.1
GTP binding protein 1
chr16_-_3767551 0.05 ENST00000246957.5
TNF receptor-associated protein 1
chr5_-_95297678 0.05 ENST00000237853.4
elongation factor, RNA polymerase II, 2
chr7_-_129592700 0.04 ENST00000472396.1
ENST00000355621.3
ubiquitin-conjugating enzyme E2H
chrX_-_153237258 0.04 ENST00000310441.7
host cell factor C1 (VP16-accessory protein)
chr17_-_40540484 0.04 ENST00000588969.1
signal transducer and activator of transcription 3 (acute-phase response factor)
chr5_-_133706695 0.04 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
cyclin-dependent kinase-like 3
chr17_+_61851157 0.04 ENST00000578681.1
ENST00000583590.1
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr8_-_29208183 0.04 ENST00000240100.2
dual specificity phosphatase 4
chr19_+_13858593 0.04 ENST00000221554.8
coiled-coil domain containing 130
chr10_-_64576105 0.04 ENST00000242480.3
ENST00000411732.1
early growth response 2
chr17_-_40540377 0.04 ENST00000404395.3
ENST00000389272.3
ENST00000585517.1
ENST00000588065.1
signal transducer and activator of transcription 3 (acute-phase response factor)
chr20_+_33292068 0.04 ENST00000374810.3
ENST00000374809.2
ENST00000451665.1
tumor protein p53 inducible nuclear protein 2
chr15_-_41047421 0.04 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
regulator of microtubule dynamics 3
chr2_+_202899310 0.04 ENST00000286201.1
frizzled family receptor 7
chr11_-_77185094 0.04 ENST00000278568.4
ENST00000356341.3
p21 protein (Cdc42/Rac)-activated kinase 1
chr19_+_54704718 0.04 ENST00000391752.1
ENST00000402367.1
ENST00000391751.3
ribosomal protein S9
chr6_+_15249128 0.04 ENST00000397311.3
jumonji, AT rich interactive domain 2
chr20_-_62258394 0.04 ENST00000370077.1
glucocorticoid modulatory element binding protein 2
chr1_+_2004901 0.04 ENST00000400921.2
protein kinase C, zeta
chr19_-_10341948 0.04 ENST00000590320.1
ENST00000592342.1
ENST00000588952.1
sphingosine-1-phosphate receptor 2
DNA (cytosine-5-)-methyltransferase 1
chr19_+_54704990 0.04 ENST00000391753.2
ribosomal protein S9
chr4_+_1873100 0.03 ENST00000508803.1
Wolf-Hirschhorn syndrome candidate 1
chrX_-_153236819 0.03 ENST00000354233.3
host cell factor C1 (VP16-accessory protein)
chr17_+_7476136 0.03 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
eukaryotic translation initiation factor 4A1
chr2_-_62115659 0.03 ENST00000544185.1
chaperonin containing TCP1, subunit 4 (delta)
chr17_+_35294075 0.03 ENST00000254457.5
LIM homeobox 1
chr2_-_62115725 0.03 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
chaperonin containing TCP1, subunit 4 (delta)
chr17_+_39845134 0.03 ENST00000591776.1
ENST00000469257.1
eukaryotic translation initiation factor 1
chr2_-_222436988 0.03 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
EPH receptor A4
chr19_+_45349432 0.03 ENST00000252485.4
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr2_-_75426826 0.03 ENST00000305249.5
tachykinin receptor 1
chr1_+_2005425 0.03 ENST00000461106.2
protein kinase C, zeta
chr17_-_40540586 0.03 ENST00000264657.5
signal transducer and activator of transcription 3 (acute-phase response factor)
chr17_-_80231300 0.03 ENST00000398519.5
ENST00000580446.1
casein kinase 1, delta
chr14_-_39901618 0.03 ENST00000554932.1
ENST00000298097.7
F-box protein 33
chr7_-_137686791 0.03 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
cAMP responsive element binding protein 3-like 2
chr19_+_52693259 0.03 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
protein phosphatase 2, regulatory subunit A, alpha
chr16_+_29911666 0.03 ENST00000563177.1
ENST00000483405.1
aspartate beta-hydroxylase domain containing 1
chr12_+_122150646 0.03 ENST00000449592.2
transmembrane protein 120B
chr4_-_186456652 0.03 ENST00000284767.5
ENST00000284770.5
PDZ and LIM domain 3
chr1_+_173837488 0.03 ENST00000427304.1
ENST00000432989.1
ENST00000367702.1
zinc finger and BTB domain containing 37
chr5_+_122424816 0.03 ENST00000407847.4
PR domain containing 6
chr2_-_64881018 0.03 ENST00000313349.3
SERTA domain containing 2
chr6_+_44355257 0.03 ENST00000371477.3
cell division cycle 5-like
chr22_+_32340481 0.03 ENST00000397492.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr1_+_180199393 0.02 ENST00000263726.2
LIM homeobox 4
chr22_+_32340447 0.02 ENST00000248975.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr12_-_51566592 0.02 ENST00000257915.5
ENST00000548115.1
transcription factor CP2
chr11_+_66059339 0.02 ENST00000327259.4
transmembrane protein 151A
chr19_-_59066327 0.02 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
charged multivesicular body protein 2A
chr11_-_67276100 0.02 ENST00000301488.3
cyclin-dependent kinase 2 associated protein 2
chr3_+_185303962 0.02 ENST00000296257.5
SUMO1/sentrin/SMT3 specific peptidase 2
chr6_-_31774714 0.02 ENST00000375661.5
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chrX_-_13835461 0.02 ENST00000316715.4
ENST00000356942.5
glycoprotein M6B
chr16_+_29973351 0.02 ENST00000602948.1
ENST00000279396.6
ENST00000575829.2
ENST00000561899.2
transmembrane protein 219
chr5_+_68513557 0.02 ENST00000256441.4
mitochondrial ribosomal protein S36
chr19_-_59066452 0.02 ENST00000312547.2
charged multivesicular body protein 2A
chr16_-_3767506 0.02 ENST00000538171.1
TNF receptor-associated protein 1
chr9_-_131644306 0.02 ENST00000302586.3
cysteine conjugate-beta lyase, cytoplasmic
chr1_-_47184745 0.02 ENST00000544071.1
EF-hand calcium binding domain 14
chr2_-_128145498 0.01 ENST00000409179.2
mitogen-activated protein kinase kinase kinase 2
chr17_-_685493 0.01 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
glyoxalase domain containing 4
chr16_+_27561449 0.01 ENST00000261588.4
KIAA0556
chr15_-_53082178 0.01 ENST00000305901.5
one cut homeobox 1
chr22_+_18121562 0.01 ENST00000355028.3
BCL2-like 13 (apoptosis facilitator)
chr9_-_131644202 0.01 ENST00000320665.6
ENST00000436267.2
cysteine conjugate-beta lyase, cytoplasmic
chr8_-_116680833 0.01 ENST00000220888.5
trichorhinophalangeal syndrome I
chr2_-_220408430 0.01 ENST00000243776.6
chondroitin polymerizing factor
chr17_-_7165662 0.01 ENST00000571881.2
ENST00000360325.7
claudin 7
chr8_+_94929273 0.01 ENST00000518573.1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr6_-_27440837 0.01 ENST00000211936.6
zinc finger protein 184
chr1_-_212208842 0.01 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
integrator complex subunit 7
chr12_-_51566849 0.01 ENST00000549867.1
ENST00000307660.4
transcription factor CP2
chr1_+_39456895 0.01 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr6_-_163148780 0.01 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
parkin RBR E3 ubiquitin protein ligase
chr1_-_150602035 0.01 ENST00000503241.1
ENST00000369016.4
ENST00000339643.5
ENST00000271690.8
ENST00000356527.5
ENST00000362052.7
ENST00000503345.1
ENST00000369014.5
ENST00000369009.3
endosulfine alpha
chr1_-_8086343 0.01 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERBB receptor feedback inhibitor 1
chr1_+_9599540 0.01 ENST00000302692.6
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr17_-_685559 0.01 ENST00000301329.6
glyoxalase domain containing 4
chr2_-_222437049 0.01 ENST00000541600.1
EPH receptor A4
chr20_+_34203794 0.00 ENST00000374273.3
sperm associated antigen 4
chr11_+_12696102 0.00 ENST00000527636.1
ENST00000527376.1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr10_-_119134918 0.00 ENST00000334464.5
PDZ domain containing 8
chr11_+_18720316 0.00 ENST00000280734.2
transmembrane protein 86A
chr5_-_132948216 0.00 ENST00000265342.7
follistatin-like 4
chr3_-_156877997 0.00 ENST00000295926.3
cyclin L1
chr4_-_122744998 0.00 ENST00000274026.5
cyclin A2
chr3_+_156544057 0.00 ENST00000498839.1
ENST00000470811.1
ENST00000356539.4
ENST00000483177.1
ENST00000477399.1
ENST00000491763.1
leucine, glutamate and lysine rich 1
chr6_+_47445467 0.00 ENST00000359314.5
CD2-associated protein

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.0 GO:0060067 cervix development(GO:0060067)
0.0 0.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.2 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.0 0.1 GO:1901856 negative regulation of cellular respiration(GO:1901856)
0.0 0.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.0 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.0 GO:0035283 rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.0 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:0060460 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) superior vena cava morphogenesis(GO:0060578)
0.0 0.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.1 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.0 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0044754 autolysosome(GO:0044754)
0.0 0.2 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)