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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F7_E2F1
Z-value: 1.75
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | -0.67 | 1.5e-01 | Click! |
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | -0.36 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.1 | 3.9 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 1.1 | 3.3 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.1 | 2.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.1 | 2.5 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.5 | 2.4 | GO:0006311 | meiotic gene conversion(GO:0006311) |
| 0.1 | 2.1 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.0 | 1.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.6 | 1.8 | GO:0060629 | regulation of homologous chromosome segregation(GO:0060629) |
| 0.2 | 1.8 | GO:0098535 | de novo centriole assembly(GO:0098535) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 2.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.8 | 2.3 | GO:0032302 | MutSbeta complex(GO:0032302) |
| 0.1 | 1.9 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 1.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.2 | 1.7 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 1.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.2 | 1.6 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 1.6 | GO:0016589 | NURF complex(GO:0016589) |
| 0.2 | 1.5 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 3.0 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.8 | 2.3 | GO:0032181 | double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
| 0.2 | 1.6 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 1.6 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.5 | 1.4 | GO:0032143 | single guanine insertion binding(GO:0032142) single thymine insertion binding(GO:0032143) |
| 0.1 | 1.3 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 1.3 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 1.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.3 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 1.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.2 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 3.5 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 3.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 2.1 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.0 | 1.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.4 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 1.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |