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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F4
Z-value: 0.93
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Transcription factors associated with E2F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F4 | hg19_v2_chr16_+_67226019_67226127 | -0.63 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_52719888 Show fit | 0.80 |
ENST00000458294.1
|
polybromo 1 |
|
| chr2_-_203736334 Show fit | 0.57 |
ENST00000392237.2
ENST00000416760.1 ENST00000412210.1 |
islet cell autoantigen 1,69kDa-like |
|
| chr2_+_172778952 Show fit | 0.56 |
ENST00000392584.1
ENST00000264108.4 |
histone acetyltransferase 1 |
|
| chr8_-_17103951 Show fit | 0.50 |
ENST00000520178.1
|
CCR4-NOT transcription complex, subunit 7 |
|
| chr2_+_71357434 Show fit | 0.50 |
ENST00000244230.2
|
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) |
|
| chr2_+_48010312 Show fit | 0.49 |
ENST00000540021.1
|
mutS homolog 6 |
|
| chr15_-_71184724 Show fit | 0.47 |
ENST00000560604.1
|
THAP domain containing 10 |
|
| chr15_+_71184931 Show fit | 0.44 |
ENST00000560369.1
ENST00000260382.5 |
leucine rich repeat containing 49 |
|
| chr1_+_60280458 Show fit | 0.43 |
ENST00000455990.1
ENST00000371208.3 |
hook microtubule-tethering protein 1 |
|
| chr9_+_17135016 Show fit | 0.40 |
ENST00000425824.1
ENST00000262360.5 ENST00000380641.4 |
centlein, centrosomal protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 0.1 | 1.0 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.0 | 0.9 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 0.8 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.8 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.1 | 0.7 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.1 | 0.7 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.7 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.1 | 0.6 | GO:0002353 | regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.0 | 0.6 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.0 | 1.3 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.3 | 1.0 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.2 | 0.9 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.1 | 0.6 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.5 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 0.4 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.1 | 0.4 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.4 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.0 | 1.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 0.7 | GO:0072591 | citrate-L-glutamate ligase activity(GO:0072591) |
| 0.0 | 0.7 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 0.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 0.6 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.6 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.1 | 0.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 0.5 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.3 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 0.3 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.3 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |