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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F3
Z-value: 2.10
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg19_v2_chr6_+_20403997_20404034 | -0.40 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_948803 Show fit | 2.69 |
ENST00000379389.4
|
ISG15 ubiquitin-like modifier |
|
| chr4_+_89299994 Show fit | 1.80 |
ENST00000264346.7
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr1_+_111682827 Show fit | 1.69 |
ENST00000357172.4
|
choline/ethanolamine phosphotransferase 1 |
|
| chr12_-_104531785 Show fit | 1.47 |
ENST00000551727.1
|
nuclear transcription factor Y, beta |
|
| chr4_+_89299885 Show fit | 1.44 |
ENST00000380265.5
ENST00000273960.3 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr16_+_48657361 Show fit | 1.42 |
ENST00000565072.1
|
RP11-42I10.1 |
|
| chr1_+_111682058 Show fit | 1.39 |
ENST00000545121.1
|
choline/ethanolamine phosphotransferase 1 |
|
| chr20_+_52824367 Show fit | 1.36 |
ENST00000371419.2
|
prefoldin subunit 4 |
|
| chr2_+_163200848 Show fit | 1.30 |
ENST00000233612.4
|
grancalcin, EF-hand calcium binding protein |
|
| chr18_-_54318353 Show fit | 1.25 |
ENST00000590954.1
ENST00000540155.1 |
thioredoxin-like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.1 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 2.9 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.2 | 2.7 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 2.7 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 2.3 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 2.2 | GO:1904896 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.4 | 1.8 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.2 | 1.8 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.1 | 1.7 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 1.7 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 2.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 1.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 1.9 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 1.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.4 | 1.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.4 | 1.8 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.1 | 1.7 | GO:1902710 | GABA receptor complex(GO:1902710) |
| 0.1 | 1.7 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | GO:0031386 | protein tag(GO:0031386) |
| 0.8 | 3.1 | GO:0004307 | diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307) |
| 0.0 | 3.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.7 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 2.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.6 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 2.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 1.9 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 1.8 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 1.8 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 2.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 2.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 1.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 3.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 2.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 2.0 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 1.9 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.8 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 1.8 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 1.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |