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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F2_E2F5
Z-value: 1.09
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F5 | hg19_v2_chr8_+_86099884_86099920 | 0.88 | 2.0e-02 | Click! |
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | -0.83 | 3.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_17935119 Show fit | 1.36 |
ENST00000317402.7
|
GEN1 Holliday junction 5' flap endonuclease |
|
| chr10_+_62538248 Show fit | 1.23 |
ENST00000448257.2
|
cyclin-dependent kinase 1 |
|
| chr2_-_17935059 Show fit | 1.09 |
ENST00000448223.2
ENST00000381272.4 ENST00000351948.4 |
structural maintenance of chromosomes 6 |
|
| chr7_+_26241310 Show fit | 1.08 |
ENST00000396386.2
|
chromobox homolog 3 |
|
| chr11_-_95522639 Show fit | 1.06 |
ENST00000536839.1
|
family with sequence similarity 76, member B |
|
| chr19_+_36705504 Show fit | 1.06 |
ENST00000456324.1
|
zinc finger protein 146 |
|
| chr19_+_36706024 Show fit | 1.02 |
ENST00000443387.2
|
zinc finger protein 146 |
|
| chr2_-_17935027 Show fit | 1.02 |
ENST00000446852.1
|
structural maintenance of chromosomes 6 |
|
| chr10_+_62538089 Show fit | 0.88 |
ENST00000519078.2
ENST00000395284.3 ENST00000316629.4 |
cyclin-dependent kinase 1 |
|
| chr7_+_26241325 Show fit | 0.88 |
ENST00000456948.1
ENST00000409747.1 |
chromobox homolog 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.3 | 2.1 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.1 | 1.8 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.6 | 1.7 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 0.1 | 1.6 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 0.2 | 1.5 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.0 | 1.4 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.2 | 1.2 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.1 | 1.1 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.2 | 1.0 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.4 | 2.1 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.3 | 2.0 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 1.8 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.2 | 1.1 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.1 | 1.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 1.0 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.2 | 0.9 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.2 | 0.9 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.1 | 0.9 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.2 | 2.4 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 2.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 1.7 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.3 | 1.6 | GO:0032142 | single guanine insertion binding(GO:0032142) |
| 0.1 | 1.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.3 | 1.1 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.2 | 1.1 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 1.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 0.9 | GO:0044388 | small protein activating enzyme binding(GO:0044388) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 1.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.1 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 1.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.1 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
| 0.0 | 0.9 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.6 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |